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Materias / palabras clave: cell death, cell biology, cancer, neurobiology, inflammation; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology

Materias / palabras clave: apoptosis, cell death, cancer, immunology, neurodegeneration, cell biology; Science: Biology (General): Cytology

The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is considered a vital component of various p...

Programmed cell death (PCD) plays a key role in developmental biology and in maintenance of the steady state in continuously renewing tissues. Currently, its existence is inferred mainly from gel electrophoresis of a poo...

Materias / palabras clave: Biology; Programmed cell death; Cell biology; Apoptosis; Biochemistry

Breast cancer is the most common malignancy in United States women, accounting for >40,000 deaths each year. These breast tumors are comprised of phenotypically diverse populations of breast cancer cells. Using a model i...

A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellul...

BACKGROUND: Nivolumab, a fully human IgG4 programmed death 1 (PD-1) immune-checkpoint-inhibitor antibody, disrupts PD-1-mediated signaling and may restore antitumor immunity. METHODS: In this randomized, open-label, inte...

BACKGROUND: Patients with advanced squamous-cell non-small-cell lung cancer (NSCLC) who have disease progression during or after first-line chemotherapy have limited treatment options. This randomized, open-label, intern...

BACKGROUND: Pembrolizumab is a humanized monoclonal antibody against programmed death 1 (PD-1) that has antitumor activity in advanced non-small-cell lung cancer (NSCLC), with increased activity in tumors that express pr...

Materias / palabras clave: Mitosis; Apoptosis; Biology; Cell biology; Involution (esoterism); Cytoplasm; Cell; Programmed cell death; Cell type; Phagosome; Embryonic stem cell; Intracellular

Materias / palabras clave: Biology; Reactive oxygen species; Signal transduction; Oxidative stress; Abiotic stress; Abiotic component; Cell biology; Cellular metabolism; Programmed cell death; Cell signaling; Mutant; Transduction (biophysics)

Several reactive oxygen species (ROS) are continuously produced in plants as byproducts of aerobic metabolism. Depending on the nature of the ROS species, some are highly toxic and rapidly detoxified by various cellular ...

The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin system. In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conser...

BACKGROUND: An improvement in overall survival among patients with metastatic melanoma has been an elusive goal. In this phase 3 study, ipilimumab--which blocks cytotoxic T-lymphocyte-associated antigen 4 to potentiate a...

BACKGROUND: Blockade of programmed death 1 (PD-1), an inhibitory receptor expressed by T cells, can overcome immune resistance. We assessed the antitumor activity and safety of BMS-936558, an antibody that specifically b...

Abstract The new edition of this well-established book is thoroughly revised and gives a comprehensive account of the role of free radicals, other reactive species (RS), and antioxidants in life, health, and disease. Cha...

Materias / palabras clave: functional cytology, immunohistochemical analysis techniques; cell differentiation and death, cellular basis of diseases, biology of cell development and senescence, functional cell and tissue biology in animals and plan...