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Materias / palabras clave: molecular genetics, genomic medicine, human genetics, genomics, medical genetics, personalised medicine; Science: Biology (General): Genetics

Materias / palabras clave: molecular genetics, metabolic pathways, inborn metabolic diseases, inherited metabolic disorders, mendelian conditions, metabolic dysfunction; Medicine: Medicine (General); Science: Biology (General)

With its theoretical basis firmly established in molecular evolutionary and population genetics, the comparative DNA and protein sequence analysis plays a central role in reconstructing the evolutionary histories of spec...

Comparative analysis of molecular sequence data is essential for reconstructing the evolutionary histories of species and inferring the nature and extent of selective forces shaping the evolution of genes and species. He...

We present the latest version of the Molecular Evolutionary Genetics Analysis (Mega) software, which contains many sophisticated methods and tools for phylogenomics and phylomedicine. In this major upgrade, Mega has been...

The Molecular Evolutionary Genetics Analysis (Mega) software implements many analytical methods and tools for phylogenomics and phylomedicine. Here, we report a transformation of Mega to enable cross-platform use on Micr...

The Molecular Evolutionary Genetics Analysis (MEGA) software has matured to contain a large collection of methods and tools of computational molecular evolution. Here, we describe new additions that make MEGA a more comp...

We announce the release of the fourth version of MEGA software, which expands on the existing facilities for editing DNA sequence data from autosequencers, mining Web-databases, performing automatic and manual sequence a...

Materias / palabras clave: Medical genetics; Workgroup; Exome sequencing; Context (archaeology); Exome; Genomics; Genetic testing; Genetics; Whole genome sequencing; Genetic association; Computational biology; Biology

Abstract The Molecular Evolutionary Genetics Analysis (MEGA) software has matured to contain a large collection of methods and tools of computational molecular evolution. Here, we describe new additions that make MEGA a ...

We present here a framework for the study of molecular variation within a single species. Information on DNA haplotype divergence is incorporated into an analysis of variance format, derived from a matrix of squared-dist...

A method is presented for the rapid isolation of high molecular weight plant DNA (50,000 base pairs or more in length) which is free of contaminants which interfere with complete digestion by restriction endonucleases. T...

Computational evolutionary biology, statistical phylogenetics and coalescent-based population genetics are becoming increasingly central to the analysis and understanding of molecular sequence data. We present the Bayesi...

We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and reverse-phase protein arrays. Our ability to integrate information ac...

Materias / palabras clave: Biology; Suite; Software; Software suite; Scale (ratio); Software development; Sequence (biology); Computational biology; Data science; Bioinformatics; Computer science; Genetics

Materias / palabras clave: Biology; Molecular genetics; Gene; Genetics; Molecular marker; Beta-glucuronidase; Library science; Gene expression; Computer science

Examining the pattern of nucleotide substitution for the control region of mitochondrial DNA (mtDNA) in humans and chimpanzees, we developed a new mathematical method for estimating the number of transitional and transve...

Materias / palabras clave: pUC19; Biology; Cloning vector; Cloning (programming); Multiple cloning site; Genetics; Plasmid; Vector (molecular biology); Molecular cloning; Nucleic acid sequence; Gene; Molecular biology

BACKGROUND: The evolutionary analysis of molecular sequence variation is a statistical enterprise. This is reflected in the increased use of probabilistic models for phylogenetic inference, multiple sequence alignment, a...

KEGG (http://www.kegg.jp/ or http://www.genome.jp/kegg/) is an encyclopedia of genes and genomes. Assigning functional meanings to genes and genomes both at the molecular and higher levels is the primary objective of the...

Current clinical practice is organized according to tissue or organ of origin of tumors. Now, The Cancer Genome Atlas (TCGA) Research Network has started to identify genomic and other molecular commonalities among a doze...

Materias / palabras clave: Plasmid; Transformation (genetics); Escherichia coli; Plasmid preparation; Biology; Incubation; Dithiothreitol; T-DNA Binary system; DNA; Transformation efficiency; Chemistry; Genetics

Materias / palabras clave: biological sciences; Science: Biology (General): Genetics

Materias / palabras clave: chromosome biology, medical genetics; Science: Biology (General): Genetics