NODOVOX | Discovery

A highly sensitive rapid diagnostic test for Chagas disease that utilizes a recombinant Trypanosoma cruzi antigen

Article

A highly sensitive rapid diagnostic test for Chagas disease that utilizes a recombinant Trypanosoma cruzi antigen

Barfield, C. A. et al · Institute Of Electrical And Electronics Engineers · 2011 · ISSN 0018-9294

Improved diagnostic tests for Chagas disease are urgently needed. A new lateral flow rapid test for Chagas disease is under development at PATH, in collaboration with Laboratorio Lemos of Argentina, which utilizes a reco...

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Coupling ELISA to smartphones for POCT of chronic and congenital Chagas disease

Article

Coupling ELISA to smartphones for POCT of chronic and congenital Chagas disease

Schaumburg, Federico et al · Elsevier Science · 2023 · ISSN 0039-9140

Chagas disease (CD) affects about 7 million people worldwide, presents a large prevalence in Latin America, and is growing in the rest of the world, where congenital CD is the main mode of transmission. Point-of-care tes...

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Genetic diversity of natural populations of Trypanosoma cruzi in clinical samples from patients with oral Chagas disease in Venezuela: Follow-up after treatment with trypanocidal drugs

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Genetic diversity of natural populations of Trypanosoma cruzi in clinical samples from patients with oral Chagas disease in Venezuela: Follow-up after treatment with trypanocidal drugs

Muñoz Calderon, Arturo Alejandro et al · Fundación Revista Medicina · 2019 · ISSN 0025-7680

Oral transmission of Chagas disease (OChD) is an increasingly important aspect in the epidemiology. Venezuela has reported the two largest outbreaks described so far, affecting a total of 192 people mostly children. The ...

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Human Trypanosoma cruzi chronic infection leads to individual level steady-state parasitemia: Implications for drug-trial optimization in Chagas disease

Article

Human Trypanosoma cruzi chronic infection leads to individual level steady-state parasitemia: Implications for drug-trial optimization in Chagas disease

De Salazar, Pablo M. et al · Public Library of Science · 2022 · ISSN 1935-2727

Currently available drugs against Trypanosoma cruzi infection, which causes 12000 deaths annually, have limitations in their efficacy, safety and tolerability. The evaluation of thera-peutic responses to available and ne...

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Input of NAcGlc6SO3 epitopes (sulfotopes) present in Trypanosoma cruzi glycoproteins, and their specific antibodies, in the infection and immune pathogenesis of experimental Chagas disease

Journal

Input of NAcGlc6SO3 epitopes (sulfotopes) present in Trypanosoma cruzi glycoproteins, and their specific antibodies, in the infection and immune pathogenesis of experimental Chagas disease

Soprano, Luciana Lía et al · Elsevier · 2018 · ISSN 1201-9712

Background: Trypanosoma cruzi, the causative agent of Chagas disease contains a major antigen, cruzipain (Cz). The C-terminal domain (C-T) of this glycoprotein bears N-linked high mannose type sulfated oligosaccharide ch...

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Prevention of congenital Chagas disease by Benznidazole treatment in reproductive-age women. An observational study.

Article

Prevention of congenital Chagas disease by Benznidazole treatment in reproductive-age women. An observational study.

Alvarez, Maria G. et al · Elsevier Science · 2017 · ISSN 0001-706X

Since the decline in new cases of infection by insect/vector, congenital Chagas disease has become more relevant in the transmission of Chagas disease. Treatment with benznidazole significantly reduces the parasitemia, w...

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Trypanosoma cruzi Induces Regulatory B Cell Alterations in Patients With Chronic Chagas Disease

Article

Trypanosoma cruzi Induces Regulatory B Cell Alterations in Patients With Chronic Chagas Disease

Girard, Magalí Celeste et al · Frontiers Media · 2021 · ISSN 2235-2988

The clinical evolution of patients with chronic Chagas disease (CCD) is mainly associated with an excessive inflammation and a defective immunomodulatory profile caused by the interaction between T. cruzi and the host. R...

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Validation of apolipoprotein A-1 and fibronectin fragments as markers of parasitological cure for congenital chagas disease in children treated with benznidazole

Article

Validation of apolipoprotein A-1 and fibronectin fragments as markers of parasitological cure for congenital chagas disease in children treated with benznidazole

Ruiz Lancheros, Elizabeth et al · Oxford University Press · 2018 · ISSN 2328-8957

Background. No reliable tests or validated biomarkers exist to ensure parasitological cure following treatment of Chagas disease (CD) patients chronically infected with Trypanosoma cruzi. As seroreversion, the only marke...

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Canine visceral leishmaniasis and Chagas disease among dogs in Araguaína, Tocantins

Article

Canine visceral leishmaniasis and Chagas disease among dogs in Araguaína, Tocantins

Arielle Nunes Morais et al · Colégio Brasileiro de Parasitologia Veterinária · 2013 · ISSN 1984-2961

The present study analyzed serum samples from 111 male and female dogs of various ages from the municipality of Araguaína in the State of Tocantins, Brazil. Serological diagnosis of canine visceral leishmaniasis (CVL) w...

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Canine visceral leishmaniasis and Chagas disease among dogs in Araguaína, Tocantins Leishmaniose visceral canina e doença de Chagas em cães de Araguaína, Tocantins

Article

Canine visceral leishmaniasis and Chagas disease among dogs in Araguaína, Tocantins Leishmaniose visceral canina e doença de Chagas em cães de Araguaína, Tocantins

Arielle Nunes Morais et al · Colégio Brasileiro de Parasitologia Veterinária · 2013 · ISSN 0103-846X

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Lack of Association of IL6 polymorphism with the susceptibility to Chagas disease in Latin American cohorts

Article

Lack of Association of IL6 polymorphism with the susceptibility to Chagas disease in Latin American cohorts

Strauss, Mariana et al · Elsevier Science · 2020 · ISSN 0001-706X

The aim of the present study was to analyze IL6 rs1800795 genetic variant in the susceptibility to Trypanosoma cruzi infection and in the development of chronic Chagas cardiomyopathy (CCC), in four independent Latin Amer...

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Elucidating the impact of low doses of nanoformulated benznidazole in acute experimental Chagas disease

Article

Elucidating the impact of low doses of nanoformulated benznidazole in acute experimental Chagas disease

Rial, Marcela S. et al · Public Library of Science (PLOS) · 2017 · ISSN 1935-2735

Fil: Rial, Marcela S. Ministerio de Salud. Administración Nacional de Laboratorios e Institutos de Salud (ANLIS) “Dr. Carlos G. Malbrán”. Instituto Nacional de Parasitología “Dr. Mario Fatala Chaben”; Argentin...

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Cardiac-oxidized antigens are targets of immune recognition by antibodies and potential molecular determinants in chagas disease pathogenesis

Article

Cardiac-oxidized antigens are targets of immune recognition by antibodies and potential molecular determinants in chagas disease pathogenesis

Dhiman, Monisha et al · Public Library of Science · 2012 · ISSN 1932-6203

Trypanosoma cruzi elicits reactive oxygen species (ROS) of inflammatory and mitochondrial origin in infected hosts. In this study, we examined ROS-induced oxidative modifications in the heart and determined whether the r...

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Phylogenetic structure of geographical co-occurrence among New World Triatominae species, vectors of Chagas disease

Article

Phylogenetic structure of geographical co-occurrence among New World Triatominae species, vectors of Chagas disease

Ceccarelli, Soledad et al · Wiley Blackwell Publishing, Inc · 2020 · ISSN 1218-1231

The tropical niche conservatism (TNC) hypothesis is one of the most prominent evolutionary hypotheses that has been supported as an explanation for the diversity gradients of several animal taxa, mainly vertebrates. Howe...

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Gene Expression Profiling and Functional Characterization of Macrophages in Response to Circulatory Microparticles Produced during Trypanosoma cruzi Infection and Chagas Disease

Article

Gene Expression Profiling and Functional Characterization of Macrophages in Response to Circulatory Microparticles Produced during Trypanosoma cruzi Infection and Chagas Disease

Chowdhury, Imran H et al · Karger · 2016 · ISSN 1662-811X

Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host?s signature ...

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Recommendations for Multimodality Cardiac Imaging in Patients with Chagas Disease: A Report from the American Society of Echocardiography in Collaboration With the InterAmerican Association of Echocardiography (ECOSIAC) and the Cardiovascular Imaging Department of the Brazilian Society of Cardiology (DIC-SBC)

Article

Acquatella, Harry et al · Mosby-Elsevier · 2018 · ISSN 0894-7317

From Centro Medico de Caracas, San Bernardino, Caracas, Venezuela (H.A.); Medstar Washington Hospital Center, Washington, District of Columbia (F.M.A., R.M.); Socor Hospital, Belo Horizonte, Brazil (M.M.B.); Faculdade de...

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Circadian entrainment by light and host in the Chagas disease vector, Triatoma infestans

Article

Circadian entrainment by light and host in the Chagas disease vector, Triatoma infestans

Valentinuzzi, Verónica Sandra et al · Taylor & Francis · 2013 · ISSN 0742-0528

Triatoma infestans (Reduviidae: Triatominae, "kissing bug") is the main insect vector of Trypanosoma cruzi, the causative agent of Chagas disease, a chronic trypanosomiasis infecting 10 million people world-wide. This he...

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Development and characterization of benznidazole nano- and microparticles: A new tool for pediatric treatment of Chagas disease?

Article

Development and characterization of benznidazole nano- and microparticles: A new tool for pediatric treatment of Chagas disease?

Seremeta, Katia Pamela et al · Elsevier Science · 2019 · ISSN 0927-7765

Benznidazole (BNZ) is the drug of choice for the treatment of Chagas disease in many countries. However, its low water solubility produces low and/or variable oral bioavailability. Thus, the aim of this work was to formu...

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Functional characterization of the kinin receptor in the Chagas disease vector Rhodnius prolixus; activity of native kinins and potent biostable Aib-containing insect kinin analogs

Article

Functional characterization of the kinin receptor in the Chagas disease vector Rhodnius prolixus; activity of native kinins and potent biostable Aib-containing insect kinin analogs

Orchard, Ian et al · Elsevier Science Inc · 2024 · ISSN 0196-9781

The causative agent for Chagas disease, Trypanosoma cruzi, is transmitted to a human host in the urine/feces of the kissing bug, Rhodnius prolixus, following blood feeding. Kinins are important chemical messengers in the...

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Chemical Communication in Chagas Disease Vectors. Source, Identity, and Potential Function of Volatiles Released by the Metasternal and Brindley's Glands of Triatoma infestans Adults

Article

Chemical Communication in Chagas Disease Vectors. Source, Identity, and Potential Function of Volatiles Released by the Metasternal and Brindley's Glands of Triatoma infestans Adults

Manrique, Gabriel et al · Springer · 2006 · ISSN 2035-2052

Compounds from the metasternal and Brindley´s glands of the blood-sucking bug, Triatoma infestans, were identified by solid phase microextraction (SPME) and gas chromatography-mass spectrometry.Volatile compounds releas...

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Control of pyrethroid-resistant chagas disease vectors with entomopathogenic fungi

Article

Control of pyrethroid-resistant chagas disease vectors with entomopathogenic fungi

Pedrini, Nicolás et al · SEDICI UNLP · 2009

Background: Triatoma infestans-mediated transmission of Tripanosoma cruzi, the causative agent of Chagas disease, remains as a major health issue in southern South America. Key factors of T. infestans prevalence in speci...

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Cuticular hydrocarbons of Chagas disease vectors in Mexico

Article

Cuticular hydrocarbons of Chagas disease vectors in Mexico

Juárez, Marta Patricia et al · SEDICI UNLP · 2002

Capillary gas-liquid chromatography was used to analyse the cuticular hydrocarbons of three triatomine species, Triatoma dimidiata, T. barberi and Dipetalogaster maxima, domestic vectors of Chagas disease in Mexico. Mixt...

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Epicuticular lipids induce aggregation in Chagas disease vectors

Article

Epicuticular lipids induce aggregation in Chagas disease vectors

Lorenzo Figueiras, Alicia N. et al · SEDICI UNLP · 2009

Background. The triatomine bugs are vectors of the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. Aggregation behavior plays an important role in their survival by facilitating the location ...

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Neglected Diseases: Drug Development for Chagas Disease as an Example

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Neglected Diseases: Drug Development for Chagas Disease as an Example

Garcia Bournissen, Facundo et al · Springer Nature Switzerland AG · 2015

Neglected diseases (NDs), also known as neglected tropical diseases, are a group of chronic diseases that disproportionately affect the poorest populations in the world. Largely ignored, children comprise a significant p...

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