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Abstract Half of all newborn neurons in the developing brain are removed via efferocytosis - the phagocytic clearance of apoptotic cells. Microglia are brain-resident professional phagocytes that play important roles in ...

ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contribut...

In the central nervous system (CNS), programmed cell death (PCD) of neurons, is precisely regulated by various biomolecules to maintain neuronal development, establish neural structures, and maintain CNS homeostasis. Und...

Although transferrin (Tf) is a glycoprotein best known for its role in iron delivery, iron-independent functions have also been reported. Here, we assessed apoTf (aTf) treatment effects on Neuro-2a (N2a) cells, a mouse n...

During aging, the brain undergoes changes that impair cognitive capacity and circuit plasticity, including a marked decrease in production of adult-born hippocampal neurons. It is unclear whether development and integrat...

Tesis de licenciatura El gen Gpm6a fue identificado como un gen de respuesta al estrés en animales sometidos a diferentes modelos de estrés crónico. En humanos, diferentes patologías neuropsiquiátricas se han asocia...

Abstract Mild traumatic brain injury (mTBI) disproportionately affects children and adolescents and has been associated with poorer neurocognitive performance, but the biological mechanisms driving symptom variability an...

Marker selection precision in neuronal studies is critical for reliable neuron identification. However, it largely depends on the experimental context. Variations in neuronal marker specificity across experimental models...

La radiación solar es uno de los parámetros más importantes para el desarrollo de aplicaciones e investigaciones relacionadas a energías renovables. Sin embargo,adquisición de mediciones de radiación solar no siemp...

Abstract Mutations in the CYFIP2 gene, particularly the R87C variant, are associated with severe epileptic encephalopathy, and present challenges for therapeutic development. This study utilized CRISPR/Cas9-edited human ...

ABSTRACT Objective This is a protocol for a Campbell review. The aim of this scoping review is to identify and map the available evidence on the association of antenatal cytokine concentrations with neurodevelopmental di...

Realizar pronósticos sobre precios resulta muy importante no sólo para la toma de decisiones de un sector productivo, sino también para la elaboración de políticas públicas; ya que permite reducir la incertidumbre ...

The signaling pathways that control embryonic development and migration of gonadotropin-releasing hormone (GnRH) neurons, as well as the postnatal fate and function of differentiated cells, are the subject of ongoing res...

Autism spectrum disorders (ASD) are a group of developmental disabilities characterized by impaired social interaction, communication deficit and repetitive and stereotyped behaviors. Neuroinflammation and synaptic alter...

Three dimensional (3D) in vitro neuronal cultures can better reproduce physiologically relevant phenotypes compared to 2D-cultures, because in vivo neurons reside in a 3D microenvironment. Interest in neuronal 3D culture...

Short-chain perfluoroalkyl substances (PFAS), such as perfluorobutanoic acid (PFBA), are increasingly detected in agricultural soils, irrigation water, and crop tissues, yet their biological effects at low, environmental...

Synaptic communication accelerates neuronal migration in the developing brain. The mammalian neocortex is one of the most intricate entities found in nature, both in terms of structure and function. It is the brain reg...

Organotypic slice culture is a sophisticated technique historically used in cellular and developmental neurobiology to investigate three-dimensional architecture and cellular interactions. Maintaining thin tissue slices ...

Brain tumors have the ability to exist even at a small size, thus making them extremely difficult to diagnose and cure. For this reason they are often considered as one of the most highly destructive and lethal groups of...

Abstract Background SPTBN1 encodes βII-spectrin, a cytoskeletal protein essential for neuronal structure and function. Pathogenic variants in this gene cause a neurodevelopmental disorder known as DDISBA (Developmental ...

Abstract Under high-altitude hypoxia, neuroinflammation contributes to cognitive impairment, though the underlying mechanisms remain unclear. In this study, we established rat and astrocyte models of hypoxic exposure. We...

Background Equine motor neuron disease (EMND) is a neuromuscular disorder that affects adult horses. Although EMND has been linked to vitamin E deficiency, its etiopathogenesis is poorly understood. Objectives To describ...

M6a is a neuronal membrane glycoprotein whose expression diminishes during chronic stress. M6a overexpression in rat primary hippocampal neurons induces the formation of filopodial protrusions that could be spine precurs...