Cerca risorse accademiche

Background: Periodontitis combined with orthodontic treatment creates a complex inflammatory and biomechanical microenvironment in gingival tissue, where macrophages play pivotal roles in tissue remodeling and immune reg...

"K-Complexes (KCs) are events present in non-rapid eye movement (non-REM) sleep, which have cellular dynamics similar to slow waves and have 3 distinguishing components: an initial P200, a posterior N500 and a final P900...

"K-Complexes (KC) are events present in non-rapid eye movement (non-REM) sleep, which have cellular dynamics similar to slow waves and have 3 distinguishing components: an initial P200, a posterior N500 and a final P900....

Protein misfolding and aggregation into amyloid fibrils (AFs) are critical issues associated with protein stability during food processing and storage, as well as with pathological damage in organisms. Hen egg white lyso...

Abstract Bacteria adjust their metabolism to the cellular energy state. AMP-forming acetyl-CoA-synthetase AcsA generates acetyl-CoA from acetate, ATP and CoA. In Bacilli, including Bacillus subtilis and Geobacillus stear...

Maintaining B-cell tolerance – the elimination of self-reactive B-cells – is literally a life-long challenge because the B-cell receptor mutates to generate millions of new variants during each immune response in the...

Abstract Esophageal cancer (EC) is a malignant tumor characterized by high incidence and mortality, and its complex pathogenesis necessitates the development of effective therapeutic strategies. In this study, we investi...

Dense granular flows through constrictions, as well as competitivepedestrian evacuations, are hindered by a propensity to form clogs. We use simulations of model pedestrians and experiments with granular disks to explore...

Mathematical models play an important role in epidemiology. The inclusion of a spatial component in epidemiological models is especially important to understand and address many relevant ecological and public health ques...

Abstract Background Circadian rhythms are endogenous, transcription-translation feedback loops that align cellular activities with the 24-h light–dark cycle. Stem-cell populations across tissues exhibit circadian oscil...

Abstract Automobile cabin air filter-deposited particulate matter represents an underappreciated exposure source, yet the differential toxicity between filter sides and underlying mechanisms remain unclear. Here, we syst...

Interferon response suppression by the respiratory syncytial virus relies on two unique nonstructural proteins, NS1 and NS2, that interact with cellular partners through high-order complexes. We hypothesized that two con...

Abstract Transcriptional regulation, critical for cellular differentiation and adaptation to environmental changes, involves coordinated interactions among DNA sequences, regulatory proteins, and chromatin architecture. ...

Abstract Background Hyperosmotic shock and the resulting cell volume compression are commonly experienced by organs such as the kidneys, causing rapid formation of hyperosmotic phase separation (HOPS) condensates in the ...

Tropomyosin is an actin-binding protein (ABP) which protects actin filaments from cofilin-mediated disassembly. Distinct tropomyosin isoforms have long been hypothesized to differentially sort to subcellular actin networ...

Oligodendrocytes (OLG) are the cells resident in the CNS responsible for myelination. OLG undergo a succession of morphological and molecular changes along several maturational stages. Galectin-3 (Gal-3) is a 25- to 35-K...

Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood. Early immune checkpoint inhibitors hav...

Benzo[a]pyrene (BaP), a widespread environmental pollutant, has been increasingly implicated in the pathogenesis of chronic degenerative diseases. Environmental pollutants have recently been recognized as emerging risk f...

Background: Barrett's esophagus (BE) represents a critical precancerous lesion arising from chronic gastroesophageal reflux disease (GERD), with significant risk of progression to esophageal adenocarcinoma. Despite advan...

Grain growth and oil biosynthesis are complex processes that involve various enzymes placed in different sub-cellular compartments of the grain. In order to understand the mechanisms controlling grain weight and composit...

Abstract Background Lung squamous cell carcinoma (LUSC) is one of the common pathological subtypes of non-small cell lung cancer, which poses significant treatment challenges due to poor response to conventional therapie...

Abstract Objective Myelodysplastic syndromes (MDS) are associated with a high risk of progression to leukemia, highlighting the critical need to explore novel therapeutic agents. Based on network pharmacology predicti...

BackgroundMast cells are abundant throughout the lung, positioned near the airway epithelium, vasculature, and interstitium where they function as frontline sentinels to inhaled environmental and chemical stimuli. Throug...

Chronic pain is a significant global health burden often resistant to conventional analgesics. Evidence implicates that mitochondrial dysfunction is not only a cellular consequence of injury, but also a fundamental drive...