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The objective of present study was to improve gastric residence time of furazolidone by preparing mucoadhesive Multiple Unit Systems (MUS) with chitosan, Hydroxypropyl methyl cellulose K4M and sodium carboxymethyl cellul...

The aim of this study was to determine the effect of Aster squamatus on gastrointestinal propulsion. Phytochemical screening suggested that stalks and roots contain steroids, terpenes, flavonoids, phenols, substances tha...

Imatinib inhibits Bcr-Abl, c-KIT and PDGFR kinases involved in chronic myelogenous leukemia and gastrointestinal stromal tumors. Mice were given imatinib PO (50 mg/kg) or IV (12.5 mg/kg) and plasma, liver, brain, spleen,...

The objective of the present study was to investigate the applicability of matrix type chitosan treated alginate multiple unit systems (MUS) for sustained release of metronidazole prepared by ionotropic gelation method. ...

The high incidence of diarrhea in the population demands a search for new therapeutic options and easy access, mainly from plant-based sources. Leaves and bark of Guazuma ulmifolia Lam. (Sterculiaceae) are popularly empl...

Gastric ulcer is one of ulcerous diseases and may result in some changes of many enzymes and transporters concerned with metabolism and disposal of drug. The pharmacokinetic of drug should be different between peptic ulc...

Aster squamatus es usado popularmente como antidiarreico, antineoplásico y cicatrizante. Los estudios anteriores demostraron un efecto antiulcerogénico del extracto hidroalcohólico crudo de la planta. Esto nos condujo...

Peptic ulcer is a chronic and recurrent disease affecting millions of people worldwide. Ulcerations can be brought about by inadequate dietetic habits leading to diminished mucosal resistance, increased acid secretion, o...

Crohn's disease occurs at any part of gastro-intestinal tract (GIT) but the most susceptible is the ileo-cecal region. For an effective treatment of this disease is essential the drug to be released at ileo-cecal regio...

The pharmacokinetics of lansoprazole after a single intravenous dose of 30 mg was determined in 10 healthy volunteers and 10 peptic ulcers patients. In this work, a liquid-liquid extraction and enrichment method with RP-...