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Ethylhexyl triazone (EHT) is a sunscreen agent widely used in the formulation of skin care products, whose physicochemical properties have not been thoroughly studied. In this work the Extended Hildebrand Solubility Ap...

The objective of the present study was to stabilize doxorubicin hydrochloride in sugar-phosphate amorphous mixtures at ambient temperature by drying it with vacuum foam drying. Finished products were evaluated for foam...

With the increasing relevance of energy transition, synthetic fuels have arisen as an alternative to storage green energy. In the processing of this fuels, carbon monoxide is widely used. Understanding the behaviour of t...

Raman spectroscopy in combination with partial least-squares (PLS) regression method was developed for sulphamethoxazole (SMZ) and trimethoprim (TMP) simultaneous determination in powder mixtures. The calibration set was...

The solubility of pioglitazone hydrochloride in polyethylene glycol 600-ethanol-water mixtures at 25 °C was determined using flask shake method. The generated data extended the solubility database for further computatio...

Propranolol-HCl (PPN-HCl) is a non selective β-adrenergic blocker widely used in therapeutics. Nevertheless, their physicochemical properties in aqueous media have not been adequately studied. In this context, by usin...

The solubility of sulfanilamide (SA) in propylene glycol + water cosolvent mixtures was determined at temperatures from 293.15 to 313.15 K. The thermodynamic functions: Gibbs energy, enthalpy, and entropy of solution and...

"The phenomenon of phase inversion occurs in liquid-liquid dispersions found in a variety of chemical engineering fields. From simple oil-water mixtures to complex polymeric systems, the operating variables that affect...

The binary solvent system ethanol + ethyl acetate is widely used in the pharmaceutical sciences as a versatile model for studying the solubility of drugs. In this context, the excess molar volumes and the partial molar v...

Paracetamol, an over the counter analgesic and antipyretic drug, causes hepatic and renal tubular necrosis at higher doses ingested accidentally, or intentionally. The situation worsens clinically upon the ingestion of p...

En el presente trabajo se estudió la descomposición térmica del efavirenz (EFZ), un no-nucleótido que es inhibidor de la transcriptasa reversa de prolongada vida media, utilizando calorimetría diferencial de barrido...

The aim of this study was to investigate the impact of solid dispersions of polyethylene glycol 6000 (PEG 6000), using the co-precipitation method, on the in vitro solubility and intestinal absorption of praziquantel (PZ...

O objetivo deste trabalho foi avaliar a atividade anitinflamatória tópica in vivo do extrato aquoso e frações do fruto de Cayaponia cabocla (Vell.) Mart. (Curcubitaceae). Extratos e frações dos frutos frescos de C....

Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to investigate drug-excipient interactions and, in consequence, their compatibility. For this purpose, binary mixtures of olanzapine ...

The present study evaluated novel polymer mixtures prepared by spray drying of an aqueous dispersion of moth bean starch with Carbopol 934P and HPMC K4M for to be used as platform for peroral mucoadhesive drug delivery...

Powder mixtures (1:1) of tibolone polymorphic forms I (monoclinic) and II (triclinic) and excipients have been prepared and compacted. The samples were stored at 50 °C and 90% RH for one month and subsequently were eval...

Con el objeto de seleccionar los medios más adecuados para la síntesis enzimática de péptidos, estudiamos el efecto de diferentes solventes orgánicos sobre la estabilidad de araujiaina (la preparación enzimática n...

Our approach to the concept of ethnicity involves the usage of instruments in many of its several dimensions: mother tongue, parental background, religion, migration events and race. In order to approximate what can be c...

Este informe describe los resultados de un estudio in vitro en el que fueron evaluados comprimidos de nevirapina (200 mg) de diferentes laboratorios brasileros. El producto roiginal fue la refencia, en comparación con c...

Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi, affects 9-12 million of people in Latin America and it is an important cause of heart disease. Although transmission has been reduced, an effective the...

The present study utilizes approach of solid dispersions (SDs) to improve dissolution rate of Gliclazide (GLZ); a poorly water soluble anti-diabetic drug. Formulations were prepared by solvent evaporation and melt disper...

En este trabajo se calcularon las funciones termodinámicas energía libre, entalpía y entropía para los procesos de solución, mezcla y solvatación de ibuprofeno (IBP) en algunas mezclas cosolventes etanol (EtOH) + a...