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The aim of the study was to characterize the preclinical pharmacokinetics and comparative pharmacokinetics of pure vitexin-2"-O-rhamnoside (VR) in mice after oral and intravenous administration at dose of 30 mg/kg. A sen...

Imatinib inhibits Bcr-Abl, c-KIT and PDGFR kinases involved in chronic myelogenous leukemia and gastrointestinal stromal tumors. Mice were given imatinib PO (50 mg/kg) or IV (12.5 mg/kg) and plasma, liver, brain, spleen,...

Tissue classification in Magnetic Resonance (MR) brain images is an important issue in the analysis of several brain dementias. This paper presents a modification of the classical K-means algorithm taking into account th...

This study aimed to evaluate the action of Brazilian green propolis (5%) topic use on cutaneous wound healing in rats, by inflammatory cell counting. Ten Wistar rats were separated in groups 24 h and 72 h, were trichotom...

Los objetivos del presente trabajo fueron comparar la penetración in líquido tisular de músculo (MTF) y tejido muscular (MT) de cefalotina administrada a conejos. Los animales fueron distribuidos en Experimento 1 (n =...

This study aimed to evaluate the effect of a diclofenac diethylammonium gel 10 mg/g (DD) on acute phase of ligature induced periodontitis model in rats. Experimental Periodontitis Disease (EPD) was induced in 30 Wistar r...