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Objective To investigate the alleviating effect of jujuboside B (JuB) on acute epilepsy in mice and its protective effect on hippocampal neurons. MethodsAn in vitro epilepsy model was established by stimulating primary h...

Abstract Background A standardized protocol for electroencephalography (EEG) under standing sedation for the investigation of epilepsy in foals is needed. Hypothesis/Objectives To evaluate a modified standardized EEG pro...

Children with epilepsy frequently experience a range of significant comorbidities beyond seizures, such as motor dysfunction, cognitive impairment, and neurodevelopmental delays. In some cases, these comorbidities contri...

Introduction The prevalence of drug-resistant epilepsy (DRE) among epilepsy patients has not decreased despite better diagnostic methods and treatment options because it affects approximately one-third of all epilepsy pa...

Animal models of epilepsy are critical in drug development and therapeutic testing. However, dominant methods for evaluating epilepsy treatments face a tradeoff between higher throughput and etiological relevance. Screen...

BackgroundValproic acid (VPA) is widely used in pediatric epilepsy, but its blood concentrations vary considerably among pediatric patients with epilepsy. This study aimed to investigate the factors influencing VPA blood...

Epilepsy is a chronic neurological disorder of the brain that affects around 50 million people worldwide. The early detection of epileptic seizures using electroencephalogram (EEG) signals is a useful tool for several ap...

Abstract Background Lesions causing refractory epilepsy, often associated with temporal lobe epilepsy (TLE), can be undetectable on standard magnetic resonance imaging (MRI) in dogs. Automated brain volumetry, widely use...

Abstract Background Antiseizure medications (ASMs) are essential for seizure control, but they are also associated with a range of adverse events that may affect treatment outcomes. Objective This study aimed to evaluate...

Abstract Background Electroencephalography (EEG) recording protocols have been standardized for humans. Although the utilization of techniques in veterinary medicine is increasing, a standard protocol has not yet been es...

Neonatal seizures are most commonly attributed to hypoxic-ischaemic injury, metabolic abnormalities, or central nervous system infections; however, an increasing proportion of cases are recognised to have an underlying g...

Abstract Background Polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome is a rare autosomal recessive mTORopathy caused by biallelic STE20‐related kinase adaptor alpha (STRADA) loss‐of‐function...

ABSTRACT Background Current diagnosis of brain disease in dogs is dependent on imaging and cerebrospinal fluid (CSF) analysis, including total nucleated cell counts and albumin concentrations. Hypothesis/Objectives To de...

Abstract Background Zonisamide (ZNS) is a newer generation antiseizure medication (ASM) used to treat epilepsy in dogs and cats. However, scientific and clinical information, particularly regarding monotherapy, is limite...

Abstract Background Brain imaging suggests the involvement of the limbic system, particularly the cingulate gyrus (GC), in dogs with idiopathic epilepsy (IE). Hypothesis A correlation exists between the side of intericta...

Abstract Background In dogs, antiepileptic drugs (AED) cause lethargy but quantitative data regarding the effects of AED on activity levels are not available, and little is known about how AEDs affect sleep quality. Obje...

Abstract Certain human mutations in the mitochondrial aldehyde dehydrogenase 4A1 (ALDH4A1) lead to a severe, paediatric form of epilepsy and developmental abnormalities, yet the precise molecular mechanism leading to the...

Abstract Background The diagnosis of idiopathic epilepsy (IE) in dogs is based on exclusion of other potential causes of seizures. Recently, a novel magnetic resonance imaging (MRI) sequence that utilizes a variant of th...

Background Psychiatric comorbidities are common in patients with epilepsy. Reasons for the co-occurrence of psychiatric conditions and epilepsy remain poorly understood.Aim We aimed to triangulate the relationship betwee...

Objectives: Psychiatric disorders are frequently found in both patients with PNES and DRE, making the differential diagnosis even more complex. The aim of this study was to analyze and compare psychiatric aspects and the...

Xiaolu Deng,1,2 Shimeng Chen,1,2 Fei Yin,1,2 Fang He,1,2 Ciliu Zhang,1,2 Lifen Yang,1,2 Leilei Mao,1,2 Li Yang,1,2 Yang Han,1,2 Jing Peng1,2 1Department of Pediatrics, Xiangya Hospital, Central South University, Changsha...

Abstract Background Approximately 30% of dogs with idiopathic epilepsy (IE) are drug‐resistant. Recent studies have suggested cannabidiol (CBD) may be an effective anticonvulsant in dogs with IE. Objective To evaluate ...

Abstract Cerebrospinal fluid metabolomics is a promising research technology in the elucidation of nervous system disorders. Therefore, in this work, a cerebrospinal fluid (CSF) metabolomics method using liquid chromatog...