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Abstract Background Systemic thrombolysis is recommended for high-risk pulmonary embolism, but is associated with a substantial bleeding risk due to thrombolysis-induced coagulopathy. However, recent advances in precisio...

Abstract Objective To investigate the association between the Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and in-stent restenosis (ISR) following percutaneous coronary intervent...

BackgroundSystemic sclerosis (SSc) is characterized by a complex and heterogeneous interplay between vascular dysfunction, immune activation, and progressive fibrosis. Despite advances in molecular characterization, ther...

Abstract Background Pediatric sepsis remains a leading cause of global mortality, necessitating early and accurate risk stratification. Traditional scoring systems often fail to capture the rapid, non-linear progression ...

BackgroundRecessive dystrophic epidermolysis bullosa (RDEB) is a devastating genodermatosis caused by biallelic COL7A1 mutations, where chronic inflammation drives disabling complications affecting quality of life and su...

ABSTRACT Background and Aims Menstrual hygiene remains a critical public health issue in Africa, where many women and girls face inadequate water, sanitation, and hygiene (WASH) facilities, limited access to menstrual pr...

Abstract Copper oxide nanoparticles (CuO-NPs) are known to trigger systemic toxicity through the disruption of copper homeostasis and the generation of profound oxidative stress. Given their widespread industrial applic...

Abstract This systematic literature review investigates how inclusive curricular interventions and pedagogy in undergraduate engineering education influence sense of belonging, professional identity, and persistence amon...

Abstract Background Oral frailty is a significant risk factor for systemic frailty and poor health outcomes in older adults. While oral health care interventions may mitigate this decline, the evidence remains fragmented...

Abstract Background Gastrointestinal dysfunction is a common and detrimental complication following stroke, closely linked to poor outcomes. Emerging evidence implicates gut microbiota dysbiosis and intestinal barrier di...

ABSTRACT Background and Aims People with mental health disorders experience disproportionately poor oral health and face persistent barriers to maintaining oral hygiene. This study aimed to assess the feasibility of supp...

The experience, expression, and exploration of emotions are central to the psychotherapeutic process, and crying is a frequent part of it. Yet, its role remains surprisingly under-researched. In the absence of establishe...

BackgroundThe intestinal barrier is a critical interface between the host and the external environment, and growing evidence indicates that bidirectional crosstalk between the gut microbiota and the intestinal barrier is...

Gastrointestinal system (GIS) manifestations are common in systemic lupus erythematosus (SLE) patients. The gastrointestinal vasculopathy of SLE is a unique clinical entity and reviewed infrequently but it should be kept...

Food insecurity affects a substantial proportion of Canadians and is strongly associated with preventable illness and increased healthcare utilization. Its consequences frequently arise in healthcare settings, where phys...

Neurodegenerative disorders represent a major and growing global health challenge, characterized by progressive neuronal loss, multifactorial pathophysiology, and limited disease-modifying pharmacological options. Increa...

This paper examines how the European Union’s Digital Services Act (DSA) understands platform addiction and, specifically, how it conceptualises its causative phenomenology: namely, the processes through which addiction...

Artificial intelligence, particularly large-language models, increasingly informs clinical decision-making, from triage to treatment recommendations. While promising efficiency and objectivity, these systems can encode a...

Abstract Objectives Burnout is a considerable challenge for healthcare personnel, particularly among surgical specialties. Although psychotropic medicines are advantageous for the treatment of psychiatric disorders, thei...

Background: Maternal mortality highlights health system effectiveness and social fairness. South Africa’s Confidential Enquiry into Maternal Deaths (CEMD) monitors and improves maternal healthcare. While initial decre...

Abstract Background Cancer treatments such as chemotherapy and radiotherapy significantly impact the cardiovascular system. While cardiac toxicity is well characterized, the effects on the aorta, the body’s largest art...

IntroductionThis study explores the systems-level dynamics of menu transformation in the hospitality and food service (HaFS) sector through participatory action learning (PAL) workshops with professional chefs. Framing t...

Abstract Background Hepatic ischemia-reperfusion injury (HIRI) is a pathophysiological process during liver transplantation, characterized by insufficient oxygen supply and subsequent restoration of blood flow leading to...

Introduction: Pneumothorax in premature neonates remains a significant clinical issue, especially when linked to respiratory distress syndrome and systemic inflammation. Providing early respiratory support and customized...