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Abstract DNA methylation quantification in age-prediction models relies on only a few techniques with inherent limitations and biases, reducing the accuracy and reproducibility. We developed a new droplet digital PCR ass...

Abstract Objectives DNA methylation (DNAm) can change dynamically in response to intrinsic or external exposures. Characteristic methylation profiles are associated with accelerated biological ageing and poorer health ou...

Objectives: An association, responsible for affecting circadian rhythms and sleep homeostasis, between PER3 gene variable number tandem repeat (VNTR) and sleep times has been described in humans. The aim of this study wa...

The temporal dynamics in biological systems displays a wide range of behaviors, from periodic oscillations, as in rhythms, bursts, long-range (fractal) correlations, chaotic dynamics up to brown and white noise. Herein, ...

Circadian rhythms are essential for maintaining intervertebral disc (IDD) homeostasis and regulate cellular metabolism, mechanical responses, and therapeutic efficacy. Core clock genes, especially CLOCK and BMAL1, have c...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease around the world, with at least 40% global prevalence. Although genetic susceptibility contributes to disease risk...

Abstract The past 25 years have seen remarkable progress in plant circadian biology. This perspective highlights major advances in our understanding of the oscillator network, the processes it regulates, and circadian va...