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Leishmaniasis is a zoonotic disease, regarded by WHO as a public health problem that has presented a significant increase in the recent years. Conventional treatment is toxic and leads to serious side effects. Photodynam...

BackgroundThis study examined the association between vitreous cellular repressor of E1A-stimulated genes 1 (CREG1) levels and the therapeutic response to ranibizumab in patients with diabetic macular edema (DME).Methods...

Pediatric cancer poses a major health challenge globally, especially in low-middle-income countries like Indonesia. The survival rate of pediatric cancer in many high-income countries (HICs) reaches 90%, while it only ra...

Existem evidências de que estrogênios, progesterona e androgênios têm efeito modulador sobre as respostas imunes humoral e celular. Estes efeitos ocorrem via interações imuno-neuroendócrinas, envolvendo a hipófis...

Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic synovial inflammation, progressive cartilage destruction, and bone erosion. Although there have been significant improvements in the use of conventio...

Cancer therapy and food preservation both face significant challenges related to stability, targeted delivery, safety, and efficiency of active compounds. Biopolymer-based nanoparticles, particularly those derived from c...

Yue Hu,1,2 Peichen Xie,2 Jialin Li,2 Rui Liu,2 Haotong Wang,2 Zhicheng Wang,2 Chunyan Liu1 1Department of Radiology, The Second Hospital of Jilin University, Changchun, People’s Republic of China; 2NHC Key Laboratory o...

BackgroundThe ubiquitin–proteasome pathway is a critical therapeutic target in malignancies, particularly multiple myeloma. The development of proteasome inhibitors (PIs) has marked a milestone in multiple myeloma ther...

ABSTRACT Diabetic wound healing is often hindered by poor outcomes, prolonged recovery, and high recurrence. To address this, a new therapy approach was demonstrated in this study, in which ginsenoside (GS) molecules are...

Abstract Background Hepatocellular carcinoma (HCC) is a critical condition characterized by unchecked cellular growth in the liver, often leading to systemic inflammation and organ failure. Although its complex molecular...

Clinical trials of adoptive cellular therapy demonstrate that a key characteristic associated with durable responses is in vivo expansion and persistence of transferred T cells. Strategies to develop a less differentiate...

Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis (TB), has killed nearly one billion people in the last two centuries. Nowadays, TB remains a major global health problem, ranking among the thirteen l...

Drug discovery research faces significant challenges, with around 90 % of candidate drugs failing in clinical trials. Traditional animal models do not always accurately reflect human physiology and pathology, leading to ...

Glioblastoma (GBM) is the most common and aggressive type of central nervous system cancer, characterized by high rates of recurrence and mortality. As the highest-grade glioma, patient prognosis remains poor despite mul...

ABSTRACT Despite the significance of adipose-derived stem cells in complementary and regenerative medicine, studies regarding clinical safety for allogeneic intravenous administration in healthy dogs remain insufficientl...

S-palmitoylation, a key reversible lipid post-translational modification, entails the covalent conjugation of palmitic acid chains to the thiol groups of cysteine residues in proteins. This modification modulates protein...

Wound healing after skin injury is a complex process, particularly in equines where leg wounds are prevalent and their repair is complicated due to the anatomical characteristics. Conventional treatments are not effectiv...

Highlights A high-density and well-structured platinum single-atom nanocatalyst (PtSNC) with pathological contexts-selective multienzyme-mimicking activities is developed to pioneer a bi-polar bioenergetic intervention s...

Abstract Therapeutic resistance remains a major cause of treatment failure and disease recurrence across cancer types, considerably limiting the long-term efficacy of chemotherapies, targeted therapies, and immunotherapi...

Cancer-associated fibroblasts (CAFs) are important stromal cells in the tumor microenvironment of lung adenocarcinoma (LUAD). This review discusses the different cellular sources of CAFs and the main signaling pathways i...

ObjectiveTo systematically evaluate the efficacy of Traditional Chinese Medicine (TCM) as an adjunctive modality in postoperative ovarian cancer management, specifically focusing on its capacity for toxicity reduction an...

IntroductionBovine mastitis remains one of the most prevalent diseases in dairy cattle and is largely managed through antibiotic therapy, which contributes to antimicrobial resistance. Host-directed strategies that enhan...

Abstract Background Circadian rhythms are endogenous, transcription-translation feedback loops that align cellular activities with the 24-h light–dark cycle. Stem-cell populations across tissues exhibit circadian oscil...

Hailing Pan,1,* Zixin Huang,2,* Aiping Li,1 Meiya Li,3 Yanxing Li,1 Ya Lin,1 Jiayin Cai1 1Department of Oncology, Traditional Chinese Medical Hospital of Wenling Affiliated to Zhejiang Chinese Medical Uni...