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Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy in which immune dysregulation and metabolic remodeling are common features. Laminin subunit alpha 3 (LAMA3), a component of lamini...

Abstract Chronic wounds represent a longstanding clinical problem due to impaired angiogenesis due to insufficient activation of vascular endothelial growth factor receptor 2 (VEGFR2). In this investigation, we used comp...

Computational modeling of protein-protein interactions (PPIs) is a high priority because it is essential for understanding nearly all cellular functions and for addressing the limitations of time-consuming experimental m...

Real-time routing on large-scale road networks remains a critical challenge for intelligent transportation systems, particularly under high query loads and increasing graph sizes. While classical shortest path algorithms...

The rapid expansion of whole-genome sequencing (WGS) has highlighted the important contribution of noncoding variants to human disease, yet their pathogenic mechanisms remain difficult to resolve. Traditional statistical...

We present a novel ultimate bound and invariant set computation method for continuous-time switched linear systems with disturbances and arbitrary switching. The proposed method relies on the existence of a transformatio...

Testaram-se variantes metodológicas utilizando azul de toluidina (AT), até se estabelecer um protocolo confiável para a avaliação computacional da compactação da cromatina em espermatozoides de galo. Para tal, for...

ABSTRACT Bio‐inspired optimisation methods have been widely applied to complex real‐world problems, particularly in low‐carbon power and energy systems, where optimisation tasks often involve high‐dimensional, co...

Goal: Analysis of the glottal area during vocal fold vibration has gained increasing attention. However, traditional analysis requires manual, frame-by-frame glottal area annotation to compute the glottal area waveform, ...

Background The long-term biological effects of low-level exposure to artificial sweeteners remain debated. We integrated computational toxicology and Mendelian randomization (MR) to explore potential biological responses...

Abstract Fewer than one thousand cataloged mechanistic annotations can be found in the open literature and databases. Here, we introduce MechFind, a computational tool that generates element and charge-balanced putative ...

We evaluate the performance of novel numerical methods for solving one-dimensional nonlinear fractional dispersive and dissipative evolution equations. The methods are based on affine combinations of time-splitting integ...

With the constant advancement of the smart grid, zero-day attack processes in Advanced Metering Infrastructure (AMI) and Supervisory Control and Data Acquisition (SCADA) networks are also continually evolving. This study...

Abstract A Schiff base ligand L 1 was synthesized via the condensation reaction between from 2-hydroxy-1-naphthaldehyde and 4-methoxyaniline. This Schiff base was employed for the preparation of metal complexes of type [...

This paper presents an innovative parallel computational methodology employing adaptive fractional differential operators to address Monkeypox epidemiological modeling challenges. The complex dynamics of such models ofte...

BackgroundGestational weight gain is closely related to maternal and infant health outcomes. Pregnant women are simultaneously exposed to four metals—lithium (Li), vanadium (V), uranium (U), and bismuth (Bi)—through ...

Abstract Background N6-methyladenosine ( $$m^{6}A$$ ) plays a crucial role in enriching RNA functional and genetic information. While deep learning has advanced $$m^{6}A$$ site identification, current state-of-the-art me...

Context. Astronomical environments are governed by a complex interplay of physical processes, including gravitational dynamics, radiative transfer, stellar evolution, chemistry, and hydrodynamics. These processes span a ...

Introduction. The performance reliability of electric vehicles (EVs) is an important factor in evaluating their suitability for widespread adoption. The reliability and lifespan of an EV depend on several critical factor...

High Angular Resolution Diffusion Imaging (HARDI) is a type of brain imaging that collects a very large amount of data, and if many subjects are considered then it amounts to a big data framework (e.g., the human connect...

Abstract Mechanical engineering structures and structural components are often subjected to cyclic thermomechanical loading which stresses their material beyond its elastic limits well inside the inelastic regime. Depend...

Abstract Alkaline water electrolysis represents a promising pathway for green hydrogen production, yet comprehensive multi-physics simulation remains computationally prohibitive for practical design optimization. This st...

Foothold selection for hexapod robots in complex terrain presents a significant challenge, demanding both high computational efficiency and robust adaptability. To address this issue, this paper introduces a foothold sel...

Abstract Advances in AI have transformed the traditional Internet of Things (IoT) into smarter, more versatile next-generation devices. Enhanced connectivity among sensors, actuators, and appliances boosts data availabil...