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A new series of heterofused thiazolo/pyrazinedione hybridswere designed, synthetized and their cytotoxicity potential wasevaluated against different cancer cell lines. Besides, druglikenessand in silico ADME/Tox studies ...

The production, distribution, and consumption of drugs has long been seen as a threat to social and economic development. On the other hand, conditions of unemployment and poverty foster expansion of illegal drug markets...

The history, policies and practice of drug control in Asia have been historically multifaceted, particularly concerning substances like opium, cannabis, and various indigenous psychoactive plants. The opium trade, notabl...

The COVID-19 pandemic prompted several drug repositioning initiatives with the aim to rapidly deliver pharmacological candidates able to reduce SARS-CoV-2 dissemination and mortality. A major issue shared by many of the ...

Abstract This study investigates the synthesis and evaluation of glycine-conjugated 5.0G polypropyleneimine dendrimers as an advanced nanocarrier system for the selective delivery of chloroquine. 5.0G PPI dendrimers were...

Abstract Hesperidin (HSP) is a bioactive flavonoid, and its activity is limited due to poor water solubility. We designed this research to develop and evaluate hesperidin nanoparticles (HSPNPs) to enhance drug release an...

The increasing complexity of pharmaceutical management in pharmacies demands efficient systems to streamline drug classification and inventory control. As pharmacies handle a diverse range of formulations, including tabl...

Developing aceclofenac hydrogel-based solid dispersions enclosed in two modified gelatin capsules for long-term medication delivery was the aim of this study. Eudragit L 100 and hydroxypropyl methylcellulose acetate succ...

ABSTRACT: Objective: To investigate the effects of commonly prescribed antibiotics and nonsteroidal anti-inflammatory drugs (NSAIDs) during early life on enamel development through a systematic review with quantitative ...

This commentary discusses the FDA’s drug approvals in 2025, with a particular focus on cancer therapies and the role of companion diagnostics (CDx). Cancer has emerged as the leading therapeutic area, accounting for 35...

Aim and Objective: The study aimed to manufacture Bucco-adhesive tablets of Risperidone and characterize the effectiveness of the drug by incorporating it into the mucoadhesive drug delivery system. The sustained release...

Researchers in pharmacy are paying increasingly close attention to nanogel-based multifunctional drug delivery systems, particularly hybrid nanogels and multicompartment nanogels because they can lead to the achievement ...

Abstract Background EUPATI Spain and EURORDIS have implemented a patient engagement model in health product research and development (R&D): international, independent Community Advisory Boards (CABs), where patients coll...

Pharmaceutical technology has increasingly integrated artificial intelligence (AI) in recent years. This technology offers significant benefits, including saving time and money while enhancing the understanding of the re...

Regulatory science governing monoclonal antibody development has undergone a profound transformation over the past decade, shifting from empiricism-driven paradigms toward evidence-efficient, mechanism-based frameworks g...

BackgroundGastric cancer (GC) exhibits marked epidemiological differences between European (EUR) and East Asian (EAS) populations, with significantly higher incidence rates in EAS. Circulating proteins represent promisin...

Sarfaraz K Niazi Department of Pharmaceutical Sciences, University of Illinois, Chicago, IL, 60612, USACorrespondence: Sarfaraz K Niazi, Email sniazi3@uic.eduAbstract: Quantum technologies—quantum computing, quantum se...

The complex etiology and short-term positive effects of treatments for osteoarthritis (OA) remain a significant challenge globally. The lack of approved disease-modifying OA drugs (DMOADs) and the rapid clearance of intr...

ABSTRACT Background and Aims De novo drug design is the process of generating novel lead compounds that possess desirable pharmacological activities and optimal physicochemical properties for therapeutic development. In ...

This article reassesses the book Africa and the War on Drugs (2012) and a related special journal issue (2016) in the light of drug market and policy developments since 2012. As part of this reassessment, we question som...

Persistent cervical human papillomavirus (HPV) infection is the key biological event underlying high-grade squamous intraepithelial lesions, cervical cancer development, and recurrence risk. Botanical drugs and their bio...

Abstract The most difficult hurdles associated with the treatment of gynecologic cancer (such as ovarian, cervical, and endometrial cancer) is chemoresistance, with ovarian cancer representing the most clinically challen...

Introduction The prevalence of drug-resistant epilepsy (DRE) among epilepsy patients has not decreased despite better diagnostic methods and treatment options because it affects approximately one-third of all epilepsy pa...

This study focuses on the development and optimization of a self-emulsifying drug delivery system (SEDDS) for Nevirapine, a BCS Class II non-nucleoside reverse transcriptase inhibitor (NNRTI) used in HIV therapy. Our obj...