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The conventional experimental methods can no longer satisfy the requirements of modern higher education in medical sciences. As a result, the integration of scientific research into experimental curricula has become more...

Abstract Introduction Trichomonas vaginalis is a protozoan parasite that causes trichomoniasis, a frequently diagnosed infection that accounts for more than half of non-viral sexually transmitted diseases. An increased i...

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The new pandemic of SARS-CoV-2 Betacoronavirus, has spread worldwide, and infected millions of individuals causing the disease denominated of COVID-19. Further on flu symptoms, due to the high tropism of virus, has most ...

Reparation of damaged tissues is an essential biological process that ensures maintenance of homeostasis. Basically it includes phases of inflammation, proliferation and remodeling. The result of healing of damaged tissu...

Sepsis is a common and important cause of mortality in critically ill patients. Acute kidney injury (AKI) is one of the most important factors determining morbidity and mortality in this clinical picture. Recent studies ...

Introduction IBS is a chronic disorder of gut–brain interaction characterized by recurrent abdominal pain associated with altered bowel habits and substantial impairment in quality of life and psychosocial functioning....

Introduction: Olfactory Reference Syndrome (ORS) is a rare, under-recognized, and understudied psychiatric condition characterized by a persistent belief about the perceived odor, ideas of reference, and engagement in re...

Pancreatitis is a heterogeneous inflammatory disorder comprising both acute and chronic forms, with pathogenesis driven by interactions among genetic susceptibility, metabolic factors, inflammatory signaling, and disrupt...

BackgroundFrailty is significantly more prevalent in individuals with Parkinson’s disease (PD) than in general population, yet the underlying neuropathophysiological mechanisms remain poorly understood. This study aime...

HELIOS is an IKAROS-family zinc-finger transcription factor that plays an important role in regulatory T cell function and conventional T cell homoeostasis. HELIOS shares a conserved N-terminal DNA-binding and C-terminal...

IntroductionHyperuricemia, pulmonary hypertension, renal failure, alkalosis (HUPRA) syndrome is a mitochondrial disease caused by mutations in SARS2 (seryl-tRNA synthetase 2), which plays a role in protein synthesis. Lim...

Thyrotoxic periodic paralysis (TPP) is a complication of hyperthyroidism that is characterized by increased Na+/K+-ATPase activity. It can present with weakness and paralysis due to massive intracellular shift of potassi...

BACKROUND: The renin-angiotensin-aldosterone system plays a central role in fibrinolysis. Activation of the RAAS stimulates the expression of plasminogen activator inhibitor (PAI-1), which can be directly implicated in t...

ABSTRACT Background and Aims Familial Mediterranean Fever (FMF) is a monogenic autoinflammatory disease caused by mutations in the MEFV gene, resulting in recurrent inflammatory episodes and a risk of developing amyloido...

Uremic pruritus is a common complication of chronic renal failure. It affects approximately half of patients undergoing dialysis treatment. Even if the pruritus is not hazardous alone, it causes physical and mental fatig...

Objective: To describe the Amyloid, Tau, Neurodegeneration (A/T/N) research framework classification in the Argentine-Alzheimer Neuroimaging Initiative (ADNI) cohort. Methods: 23 Mild Cognitive Impairment (MCI), 12 Alzhe...

The goal of the medical specialty of geriatrics is to treat the complicated needs of elderly patients while highlighting the need of preserving functional independence in the face of chronic illnesses. A unique and compr...

Abstract Heart failure (HF) is a common disease resulting in high morbidity, mortality, and healthcare costs. An important cause of HF is mitral valve regurgitation (MR), which induces left ventricular remodeling and vol...

Background and purposeRadiotherapy (RT) often causes delayed radiation-induced brain injury (RBI) with unclear pathophysiology; emerging evidence links this to glymphatic dysfunction, but radiation effects on cerebrospin...

One foundational goal of global health and a shared inspiration for all humankind is to reduce premature mortality from preventable and treatable conditions. This imperative becomes markedly more urgent for the uniquely ...

An increased permeability of the intestinal barrier is proposed as a major event in the pathophysiology of conditions characterized by chronic gut inflammation. This study investigated the capacity of pure anthocyanins (...

Abstract Objective: MOTS-c is a mitochondria-derived peptide associated with reduced insulin resistance and obesity. The m.1382A>C polymorphism of the MOTS-c gene is linked to an increased risk of type 2 diabetes in men...