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Abstract Juvenile idiopathic arthritis (JIA) comprises a heterogeneous group of childhood-onset inflammatory arthritides that remain challenging to treat. An expanding range of biologic and targeted synthetic disease-mod...

ABSTRACT Background and Aims Propolis is a natural resinous substance produced by bees, recognized for its antioxidant and anti‐inflammatory properties. Previous clinical trials have reported inconsistent results regar...

Background Non-invasive brain stimulation (NIBS) techniques, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), may offer an alternative treatment strategy for impulsive b...

Abstract This meta-analysis aimed to code active cognitive behavioral elements in mental health apps and to examine the association between these elements and improvements in depression and anxiety. Trials evaluating men...

BackgroundRandomised controlled trials (RCTs) are widely accepted as the preferred study design for evaluating healthcare interventions. When the sample size is determined, a (target) difference is typically specified th...

Abstract Background Adaptive designs (ADs) are increasingly used, whereby outcome data accumulated during the trial may inform a trial’s course in accordance with pre-specified rules at interim analyses. The benefits h...

Abstract Background Randomised controlled trials (RCTs) are often considered the gold standard in research design to determine clinical and cost-effectiveness, and yet the majority are not considered “informative” or...

The objective of this work was to perform a quantitative analysis of the amino acid composition of soybean seeds as affected by climatic variables during seed filling. Amino acids were determined from seed samples taken ...

BackgroundPivotal clinical trials form the evidentiary foundation for FDA oncology drug approvals, yet persistent disparities in participant demographics may limit the generalizability and equity of cancer care. This stu...

Abstract Background Sorafenib has served as standard treatment for advanced hepatocellular carcinoma (HCC). Recently, several randomized controlled trials (RCTs) have explored the use of programmed cell death protein 1/p...

Abstract Background Ureteral double-J (JJ) stents are widely used in endourological practice but are frequently associated with discomfort and stent-related morbidity, particularly during removal. Extraction-string stent...

Objective: To evaluate the efficacy and safety of Ganmai Dazao (GMDZ) decoction alone and in combination with antidepressant medication or psychotherapy for depression. Methods: We searched seven electronic databases fro...

Abstract Background Epidemiological data consistently associate low vitamin D status with elevated cardiovascular risk, yet causal mechanisms remain contested. Methods This review synthesized evidence through a protocol-...

Abstract The field of regenerative medicine for Parkinson’s disease (PD) has reached a pivotal moment. After decades of preclinical research, recent first-in-human clinical trials demonstrated that cell replacement the...

Abstract Background There has been a recent push for biomedical research to incorporate more demographically, ethnically, and medically diverse cohorts – individuals whom the NIH designates as “underrepresented in bi...

Abstract Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for the management of type 2 diabetes and obesity, yet their long-term cardiovascular effects in high-risk populations continue to ...

As síndromes hipertensivas na gestação merecem especial destaque no cenário da saúde pública mundial. Atualmente, respondem como terceira causa de mortalidade materna no mundo e primeira no Brasil. Do ponto de vist...

Abstract Background and objectives The under-representation of vulnerable groups in clinical trials, including persons with disabilities, could affect the applicability of trial findings to real-world public health inter...

Background and purpose: Deviations in radiotherapy quality can significantly affect clinical trial outcomes, including overall survival. Radiotherapy quality assurance (RTQA) is a systematic process by which a RT plan is...

Abstract Background Pre-eclampsia is a multisystem disorder affecting 2.8% of pregnancies in the UK. It usually presents after 20-week gestation with new-onset high blood pressure and proteinuria. Complications include e...

Objective: To systematically review and compare postoperative pain levels following NSET using calcium silicate-based sealers versus traditional sealers. Material and Methods: This systematic review adhered to PRISMA 202...

BackgroundExercise interventions have been increasingly identified as potential non-pharmacological approaches to ameliorate cognitive and behavioural performance among children with Attention-Deficit/Hyperactivity Disor...

A study was conducted to evaluate the predictive diagnostic value of different copper (Cu) parameters as indicators of average daily gain (ADG) in growing calves. The effects in calves of cow Cu supplementation in the la...