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Necroptosis, a regulated form of necrotic cell death governed by the RIPK1-RIPK3-MLKL axis, is critically involved in host defense, inflammatory responses, and the pathogenesis of diverse diseases. Given the expanding co...

Background: Periodontitis combined with orthodontic treatment creates a complex inflammatory and biomechanical microenvironment in gingival tissue, where macrophages play pivotal roles in tissue remodeling and immune reg...

Abstract Complex systems often involve interactions within groups, namely higher-order networks, rather than simple pairwise connections, which fundamentally reshape how collective dynamics unfold. However, it remains po...

How do living systems sustain communication, identity, and resilience while remaining exposed to disorder and environmental perturbations? How do poly-genomic organisms integrate evolutionary history (including non-genet...

Abstract Traffic flow prediction is a fundamental building block for Intelligent Transportation Systems (ITS), enabling proactive congestion mitigation, adaptive traffic signal control, and reliable route guidance. Howev...

Real-time routing on large-scale road networks remains a critical challenge for intelligent transportation systems, particularly under high query loads and increasing graph sizes. While classical shortest path algorithms...

Abstract Advances in artificial intelligence (AI) and multi-omics integration are reshaping precision oncology by enabling deeper mechanistic understanding, improved characterization of tumor heterogeneity, and the accel...

Abstract While both common and rare variants contribute to the genetic etiology of complex traits, whether their impacts manifest through the same effector genes and molecular mechanisms is not well understood. Here, we ...

Abstract Marine habitat maps are essential tools for marine spatial planning, providing information for decision‐making in conservation and resource management. Accurate classification of benthic habitats supports thei...

Abstract Nanofluids have emerged as promising heat transfer media due to their superior thermal performance associated to conventional fluids, yet their behavior under mutual impacts of radiation, heat source/sink, and m...

Biological neural network functionality depends on the vast number of connections between nodes, which can be challenging to implement artificially. One radical solution is to replace physical wiring with broadcasting of...

In the modern globalized world, political processes increasingly occur as a result of interactions between individual actors who form networks. Contemporary political processes are examined through the lens of Policy Net...

Recently, in the image super-resolution (SR) domain, Transformers have outperformed Convolution Neural Networks (CNNs) with reduced computational complexity and parameters by modeling long-range dependencies input-depend...

This research contributes to ongoing, multi-faceted, and much-needed discussions about food systems change amidst rising rates of food insecurity in Canada (and globally). It does so by providing a comparative content an...

Networks have recently become ubiquitous in many scientific fields. In criminology, social network analysis (SNA) provides a potent tool for analysis of organized crime. This paper introduces basic network terms and meas...

The need for early and precise identification of abnormalities has made the detection and classification of brain tumours essential components of medical diagnosis. Because brain tumours are naturally complex and can hav...

Abstract Graph neural networks (GNNs) are widely used as surrogates for costly experiments and first-principles simulations to study the behavior of compounds at atomistic scale, and their architectural complexity is con...

IntroductionLiver diseases continue to impose a major global health burden, and therapeutic progress is constrained by the limited availability of validated small-molecule modulators. TEAD4, a central Hippo-YAP effector,...

"Complex networks theory have gained wider applicability since methods for transformation of time series to networks were proposed and successfully tested. In the last few years, horizontal visibility graph has become a ...

Background and aims Meat-borne Staphylococcus aureus (S. aureus) remains a leading global foodborne pathogen harbouring novel enterotoxin genes (NEGs) encoding superantigenic toxins with conditionally enhanced pathogenic...

ABSTRACT Background and Aims De novo drug design is the process of generating novel lead compounds that possess desirable pharmacological activities and optimal physicochemical properties for therapeutic development. In ...

Research objective. This article analyses the transformation of the communication system of Ukrainian sailors' wives during the Soviet and post-Soviet periods. The research aims to identify changes in the forms and pract...

Abstract Background Reliable identification of protein‑protein interactions (PPIs) is crucial for deciphering cellular functional networks. Current research models still face limitations in aligning heterogeneous featu...

The rapid growth and increasing complexity of Internet of Things (IoT) networks require efficient real-time monitoring and anomaly detection mechanisms. Traditional machine learning approaches often struggle to handle th...