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Common variable immunodeficiency (CVID) is a group of heterogeneous disorders with common denominators of impaired antibody production and function and recurrent infections. Currently, prognostic biomarkers for CVID are ...

Abstract Background The MARS PETCARE BIOBANK™ (MPB) is a study recruiting pets visiting Mars Veterinary Health hospitals in the USA over a ten-year period, with the aim of analysing longitudinal data from thousands of ...

Background and purpose: Artificial intelligence-based contouring tools enable assessment of radiation doses to cardiac substructures beyond mean heart dose. This study examined inter-solution variations in raw contours a...

Abstract Background Early detection of renal involvement in ANCA-associated vasculitis (AAV) is crucial, as functional changes often precede anatomical damage. Current diagnostic standards, such as the measurement of ser...

Abstract Cooperation is the cornerstone of human societies, and its emergence is firmly linked to enhanced tolerance and egalitarianism. However, evidence of profuse cooperation in less tolerant and despotic societies ch...

Abstract BackgroundManaging type 2 diabetes (T2D) requires ongoing attention to diet, physical activity, medication, and blood glucose monitoring. These cumulative demands can lead to diabetes distress, a com...

BackgroundInsomnia is highly prevalent among adolescents. It is associated with various mental and physical disorders and impairments in daytime functioning. Cognitive behavioral therapy for insomnia (CBT-I) is well supp...

Lung transplantation (LTx) remains limited by high immunogenicity and chronic rejection, yet the application of donor-specific blood transfusion (DSBT) in LTx has not been fully investigated. We established a murine orth...

This study presents PrimDx, a diagnostic test that applies machine learning (ML) to whole blood transcriptomic data to improve early detection and diagnosis of primary immunodeficiency (PID). Delays in PID diagnosis are ...

Abstract Background The contact activation system is triggered when blood comes into contact with artificial surfaces. Cardiopulmonary bypass (CPB) induces such activation, however the extent of factor XII (FXII) reducti...

Abstract Background Despite the expansion of antiretroviral treatment programmes, the incidence and mortality of HIV-associated cryptococcal meningitis remain high in Africa. Cryptococcal antigen (CrAg) in the blood prec...

RationaleCommon variable immunodeficiency (CVID) is a chronic, multisystem immune disorder associated with substantial symptom burden beyond infections, particularly among individuals with noninfectious inflammatory comp...

BackgroundChronic granulomatous disease (CGD) is characterized by defective neutrophil oxidative burst activity with subsequent susceptibility to catalase-positive organisms, invasive fungal infections, in addition to in...

Abstract Background Systemic hypertension (SH) is a potential complication of acute kidney injury (AKI) in dogs. Objective To describe the prevalence of SH and hypertensive retinopathy in dogs with AKI, to investigate th...

Objectives To establish the incidence of developing diabetes mellitus (DM) post hospitalisation with influenza.Design Retrospective cohort study.Setting Electronic healthcare records from Clinical Practice Research Datal...

Abstract Background Adrenaline is an emergency medication used in critical situations. However data on its early adverse events after intravenous injection are limited. Therefore, the goal of this study is to describe th...

In “Mexiletine in the treatment of LQT2, LQT3, and acquired LQTS: a meta-analysis” (Indonesian Journal of Cardiology, 46(2), 71-79. https://doi.org/10.30701/ijc.1835), there is an error noted. An error has been found...

Abstract Background Tauopathies are a group of neurodegenerative diseases, including Alzheimer’s disease (AD), characterized by progressive accumulation of pathological Tau proteins. Among the diverse Tau species, trun...

OBJECTIVE: The aim of this study was to explore the prospective association between compositions of accelerometry-measured occupational physical behaviors and the risk of knee pain among eldercare workers. METHODS: We pe...

O presente artigo argumenta sobre a importância de políticas de Saúde e Segurança Públicas que sustentem programas voltados à saúde do trabalhador na Brigada Militar. Aborda, mais especificamente, a necessidade de...

Abstract Background Preoperative anxiety is a common challenge in paediatric anaesthesia. High anxiety levels are associated with adverse perioperative outcomes. Although risk factors for preoperative anxiety in children...

The prediction and design of photonic features have traditionally been guided by theory-driven computational methods, spanning a wide range of direct solvers and optimization techniques. Motivated by enormous advances in...

Pain after surgery is of major perioperative concern because it is associated with substantial complications, including chronic post-surgical pain (CPSP) development. The CPSP incidence is high, and its accurate predicti...