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Background Non-suicidal self-injury (NSSI) is a frequent and prominent phenomenon in major depressive disorder (MDD). Even though its prevalence and risk factors are relatively well understood, the potential mechanisms o...

Abstract Background Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder that is linked to cardiovascular, metabolic, and neurocognitive complications. However, its diagnosis relies on polysomnograp...

Abstract Background Estrogen receptor alpha (ERα)-positive luminal breast cancer is commonly treated with aromatase inhibitors (AI) to block estrogen signaling; however, resistance frequently develops, limiting therapy ...

Abstract DNA methylation quantification in age-prediction models relies on only a few techniques with inherent limitations and biases, reducing the accuracy and reproducibility. We developed a new droplet digital PCR ass...

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) stands as the most widespread chronic liver disorder globally. Histone β-hydroxybutyrylation (Kbhb)—a novel post-translational modif...

La epigenética, concepción frecuentemente atribuida a Corad Waddington (1905-1975), ha estado estrechamente relacionada a una lucha en el campo intelectual por más de dos mil años. Postulada por Aristóteles bajo la ...

Genomic and darwinian medicine deal with the application of hereditary and evolutionary principles for the understanding of health and disease. The progress in molecular and bioinformatic knowledge is making possible thr...

El debate actual en biología evolutiva está focalizado en los aportes de la epigenética, en los cambios conceptuales del término "gen" y sus repercusiones en la teoría sintética de la evolución. En este sentido, s...