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Abstract Cognitive dysfunction is a common symptom of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, and is known to be caused by the structural and function...

Gastrointestinal (GI) diseases are common multifactorial disorders involving chronic inflammation, epithelial barrier disruption, immune dysregulation, gut microbiota imbalance, and abnormalities in motility and gut–br...

Introduction Hyperlipidemia serves as a significant risk factor for cardiovascular diseases and cognitive impairment, making early intervention and management highly necessary. Infrared moxibustion, a modern complementar...

Kai Chen,1,* Yiqing Nong,1,* Ying Liu,2 Ziming Ye3 1Department of Neurology, Guangxi Medical University Kaiyuan Langdong Hospital, Nanning, 530023, People’s Republic of China; 2Department of Rehabilitat...

Neurodegenerative disorders represent a major and growing global health challenge, characterized by progressive neuronal loss, multifactorial pathophysiology, and limited disease-modifying pharmacological options. Increa...

Abstract Periventricular nodular heterotopia is a common neuronal malformation in humans, often leading to epilepsy and other neurologic diseases. A 2‐month‐old female Chihuahua weighing 750 g was examined because ...

Background: Outer membrane vesicles (OMVs) from Gram-negative bacteria are spherical lipid bilayer nanostructures with diameters of 20 to 250 nm. Porphyromonas gingivalis (P. gingivalis), a keystone periodontal pathogen,...

In the central nervous system (CNS), programmed cell death (PCD) of neurons, is precisely regulated by various biomolecules to maintain neuronal development, establish neural structures, and maintain CNS homeostasis. Und...

ObjectiveChronic pain, a major global public health burden, is primarily driven by altered central pain processing, which conventional treatments rarely target directly. This systematic review and meta-analysis synthesiz...

Abstract Purpose Prader-Willi Syndrome (PWS) is a rare genetic disorder with a heterogeneous phenotype, caused by loss of expression of genes on the paternally inherited chromosome 15q11.2-15q13.3, primarily due to pater...

Abstract Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) characterized by multifocal inflammation and axonal degeneration, driven by innate and adaptive immune cells. Th...

IntroductionRecent research has highlighted the role of the gut microbiome in shaping the development and function of the mammalian immune system. Interactions between these complex networks of microbes and host cells se...

The transition to active rehabilitation in concussion care requires precise tools to identify patients at risk of persistent post-concussive symptoms (PPCS). While machine learning (ML) offers the potential to personaliz...

Abstract Background Triggering receptor expressed on myeloid cell-2 (TREM2) signaling promotes disease-associated microglia (DAM) and phagocytosis in neurodegenerative diseases. Traditional anti-TREM2 agonist antibodies ...

OBJECTIVE: Cardiovascular diseases are prevalent in asymptomatic chronic hemodialysis patients. New cardiac biomarkers are required for early diagnosis of cardiovascular diseases. In our study, we aimed to investigate as...

IntroductionSouth American camelids (SACs) and dromedaries presenting with neurological abnormalities are increasingly common in veterinary practice. Advanced diagnostic imaging techniques, such as computed tomography (C...

Abstract Transmissible spongiform encephalopathies, or prion diseases, are fatal neurodegenerative diseases that are medically, economically, and ecologically important. In livestock and wildlife, detection to prevent in...

Abstract Feline morbillivirus (FeMV) is a recently discovered morbillivirus of the family Paramyxoviridae, which include several highly contagious viruses with zoonotic potential. In this case report we describe the dete...

Abstract The heart-brain axis is a significant contributor to morbidity and mortality following ischemic injury. Pathological and psychological changes in the heart can lead to anxiety, cognitive impairment, and brain in...

Autism spectrum disorders (ASDs) are neuropsychiatric diseases characterized by impaired social interaction, communication deficits, and repetitive and stereotyped behaviors. ASD etiology is unknown, and both genetic and...

Microplastics (MPs), environmental pollutants resulting from the degradation of plastic products and industrial processes, have become ubiquitous in global ecosystems. MPs can enter the human body through ingestion, inha...

Abstract The genomic locus that encodes the Leucine-rich repeat kinase 2 (LRRK2) gene is highly pleiotropic and associated with Parkinson’s disease (PD). Coding variants associated with risk of PD act as gain of functi...

Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation...