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Abstract Objective Streptococcus agalactiae is an important pathogen in neonates and pregnant women. Neonatal invasive infections due to S. agalactiae are life-threatening and preventive strategies for this challenge o...

Abstract Objective To examine whether long-term opioid use after total knee arthroplasty (TKA) is associated with subsequent risks of major adverse cardiovascular events (MACE) and all-cause mortality in patients with kn...

Abstract Background Cardiometabolic multimorbidity (CMM) leads to adverse health outcomes. Based on data from the China Health and Retirement Longitudinal Study (CHARLS), we aimed to explore the cumulative exposure and d...

BackgroundPrimary ciliary dyskinesia (PCD) management relies on mucociliary clearance to prevent bronchiectasis. While humoral immunodeficiencies have been reported in PCD, their clinical significance remains under-defin...

Celiac disease (CD) and Hashimoto’s thyroiditis (HT) frequently coexist, suggesting that shared mechanisms of autoimmunity extend beyond the intestine. In CD, the pathogenic role of gluten is firmly established; in HT,...

Abstract Background Cardiogenic shock (CS) and Acute Renal Failure (ARF) have a compounding impact on patient survival. The long-term epidemiological burden of this cardiorenal comorbidity remains understudied despite th...

RationaleGenetic testing can reveal a molecular diagnosis in 20–40% of patients with inborn errors of immunity (IEI) such as predominantly antibody deficiencies (PAD), though this varies by IEI type and other factors. ...

Aim. To determine the clinical features of moderate community-acquired pneumonia (CAP) associated with COVID-19 in patients without comorbidities compared to those with comorbid metabolic dysfunction-associated steatotic...

Objective: This study aims to analyze the comorbidity profile of patients with severe asthma undergoing benralizumab therapy in a Romanian academic center, focusing on the impact of these comorbidities on disease managem...

ABSTRACT Background and Aims In‐hospital death and recovery are competing risks in COVID‐19 patients, complicating prognosis. While international prognostic scores exist, their reliance on complex biomarkers limits t...

Aim: To determine tear mucin levels in patients with type 2 diabetes mellitus (T2DM) and correlate them with the levels of the neutrophil activation marker CD15+ in epithelial cells of the bulbar conjunctiva in patients ...

Background Depression is a common comorbidity in Parkinson’s disease (PD) and Lewy body dementia (LBD). However, studies examining the rate of incident depression in the period preceding and following the diagnosis of ...

Abstract Background Delayed ambulation recovery following major abdominal surgery presents a significant prognostic challenge, contributes to increased morbidity, mortality, and prolonged hospital stay. Despite recommend...

Background: Nearly half of patients with thoracic cancer are diagnosed at a late stage, contributing to poor survival. This may be due to delays in diagnosis. Methods: This study established a longitudinal cohort by link...

BackgroundFrailty is recognized as an important predictor of postoperative outcomes, yet evidence on the differential association between the 5-factor modified frailty index (mFI-5) and specific postoperative pulmonary c...

ObjectiveTo identify sleep-disordered breathing phenotypes in older adults with depressive disorder and obstructive sleep apnea-hypopnea syndrome (OSAHS) and to evaluate their associations with systemic inflammation.Meth...

Introduction: Chronic Kidney Disease (CKD) affects more than 800 million people worldwide. Patients undergoing haemodialysis often experience increased stress and compromised cardiovascular health, which may affect treat...

Background The comorbidity of cardiovascular disease (CVD) and depression has been well established, as depression usually presents simultaneously with CVD risk factors. However, the potential association between cumulat...

BackgroundPatients with rheumatoid arthritis (RA) and concomitant fibromyalgia (FM) frequently experience severe, refractory pain, elevated disease activity scores, and substantial psychological distress. Conventional tr...

Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by β-cell destruction and insulin deficiency. Circulating microRNAs (miRNAs) are promising biomarkers for disease monitoring and complication risk as...

Objective: This study aimed to determine the rate of registration on a kidney transplant waiting list and to investigate related factors in our geographical region. Materials and Methods: We conducted this study with 3...

The fascia, a pervasive connective tissue network, has traditionally been studied for its structural and biomechanical roles in the human body. However, emerging evidence suggests that fascia may also play a significant ...

Abstract Purpose Fibromyalgia is a chronic pain syndrome characterized by central sensitization and frequent comorbidity clustering. Its impact on early readmission and procedural utilization during readmission after ele...

Objective: Evaluate whether implementation of an academic trauma team and a dedicated orthopaedic trauma room (DOTR) reduces surgical delay and improves efficiency in hip fracture management at a Level III trauma center....