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This study focuses on the development and optimization of a self-emulsifying drug delivery system (SEDDS) for Nevirapine, a BCS Class II non-nucleoside reverse transcriptase inhibitor (NNRTI) used in HIV therapy. Our obj...

Objective: Development & Optimization of Ofloxacin Floating tablets to enhance gastric retention time. Sustained release effect of formulation will reduce the dosing frequency for UTIs and prolonged local effect will ben...

Closely linked to the increase in psychotropic pill consumption, forgetting and remembering emerged from devastated social scenarios as a new local idiom among poor youth in the late 1990s and the new millennium. Drawing...

Abstract Breast cancer remains one of the most prevalent malignant tumors affecting women worldwide and continues posing a major threat to global health. Current clinical treatments include surgery, chemotherapy, radioth...

In recent decades, drug crop eradication and drug trafficking interdiction have pushed drug crop cultivation into new areas of the Amazonian rain forest. The presence of the drug industries in these regions—followed by...

BackgroundThe ubiquitin–proteasome pathway is a critical therapeutic target in malignancies, particularly multiple myeloma. The development of proteasome inhibitors (PIs) has marked a milestone in multiple myeloma ther...

RationaleCancer remains one of the most formidable challenges in mordern medicine. Chemoresistance, particularly resistance to platinum-based agents, presents a major challenge in effective treatments. In response to thi...

Considerable resources have been spent on estimating the size of populations of people who use drugs (PWUD) and people who inject drugs (PWID) in Africa. Precise estimates are elusive, not least because of stigma and cri...

Sujong Lee,1,2 Heejae Won,1,2 Kyung-Sang Yu,1,2 Dae Young Lee,3 SeungHwan Lee1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea; ...

African countries have been experiencing an upsurge in public health problems as a result of the increased availability and use of psychoactive substances trafficked into the continent and also produced locally. However,...

Silicosis is an occupational fibrotic lung disease representing a major public health crisis, and places a significant burden on patients and healthcare systems. There are no curative treatments for patients with silicos...

Every human being is endowed with emotions that can be well-controlled, as evidenced by the ability to regulate emotions. The gap relates to the understanding of emotional regulation in the context of drug addiction by a...

Abstract Health is part of the Sustainable Development Agenda adopted by the United Nations and local communities have an important role in the definition of their own development needs and in the discussion of the post-...

Abstract Background The antibiotic resistance of Klebsiella pneumoniae poses significant challenges in veterinary clinical settings and threatens poultry production. Veterinarians often employ combination therapy to addr...

The fight against street‐level drug crime cannot be won by spending more resources on traditional, reactive style police work. Rather, partnerships between the police and other “third parties” should be applied, su...

Antibody-drug conjugates (ADCs) combine the target specificity of monoclonal antibodies with the cytotoxic potency of small-molecule payloads. In recent years ADCs have emerged as a clinically validated component of mode...

Abstract Background Drug-induced liver injury (DILI) remains a significant barrier to the safe and efficient use of antimalarial medicines. Many promising compounds fail in late-stage development or post-marketing owing ...

B cell-mediated immunity plays a crucial role in long-term humoral protection. However, dysregulation of B cell development and differentiation may lead to the persistence of autoreactive clones, contributing to autoimmu...

ABSTRACT Neuroinflammation is a core pathological mechanism in neurodegenerative diseases. Although natural many compounds, derived from traditional Chinese medicine have shown promise in modulating neuroinflammation, co...

Abstract Background Mirogabalin and trimethoprim-sulfamethoxazole (TMP/SMX) are frequently used as supportive purpose during and/or after chemotherapy. Mirogabalin is used to treat neuropathic pain, whereas TMP/SMX is us...

Endothelial glycocalyx dysregulation remains the leading cause of the development and progression of cardiovascular diseases, which can increase the risk of organ failure and even cause death. However, the construction o...

Drug discovery research faces significant challenges, with around 90 % of candidate drugs failing in clinical trials. Traditional animal models do not always accurately reflect human physiology and pathology, leading to ...

Quinolines are well-established scaffolds in drug discovery and form the core of many FDA-approved medicines. Among their reduced analogues, hexahydroquinolines (HHQs) have gained increasing attention due to their struct...

The illicit drug trade generates billions of dollars and sustains transnational criminal organisations. Drug markets can destabilise governance and undermine development. Data indicate increasing drug use in South Africa...