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ObjectiveThis systematic review and meta-analysis aims to evaluate the effects of Tai Chi Chuan on the expression of pro-inflammatory genes IL-6, IL-1β, and TNF-α—downstream of the NF-κB pathway—in adults with chr...

Individuals who exhibit male external genitalia and testicular tissue despite a 46,XX karyotype with SRY-Negative represent an exceptionally rare phenotype of disorders of sex development (DSD), and the underlying mechan...

The present study investigated the role of the N, N{ 0 }-dimethylbiguanide metformin (50 mg/100 g body weight in 0.05 ml water, given orally with a canulla) in the prevention of endocrine and immune disorders provoked by...

The growing use of digital technology has created a new form of chronic psychological stress. Digital stress significantly affects female hormonal and reproductive health. This systematic review explores how digital and ...

Abstract Background Resistance to thyroid hormone (RTH) is a rare endocrine disorder, most commonly caused by mutations in the thyroid hormone receptor β (TRβ) gene, resulting in the RTH beta (RTHβ) subtype. In contra...

Celiac disease (CD) and Hashimoto’s thyroiditis (HT) frequently coexist, suggesting that shared mechanisms of autoimmunity extend beyond the intestine. In CD, the pathogenic role of gluten is firmly established; in HT,...

Abstract Objective Obesity has become one of the most common disorders in the world and causes a significant public health challenge. Genome-wide association studies (GWAS) have identified variants within the FTO gene as...

IntroductionParkinson’s disease (PD) is a progressive neurodegenerative disorder for which there is no cure. Diabetes is one of the risk factors for developing PD. Tirzepatide is a novel long-acting glucagon-like pepti...

Abstract Background Metabolic dysfunction-associatedsteatotic liver disease (MASLD) has become the most prevalent chronic liver disease worldwide. Its incidence continues to rise with a marked trend toward younger age gr...

Abstract Background Inpatient hypoglycemia is a serious complication in hospitalized patients with type 2 diabetes mellitus (T2DM), associated with adverse outcomes. While insulin resistance (IR) is central to hyperglyce...

Abstract Background The triglyceride-glucose (TyG) index has emerged as a surrogate marker for insulin resistance. This systematic review and meta-analysis of observational studies aimed to investigate the association be...

Abstract Purpose Currently, there is a lack of early biomarkers to identify the risk of dysglycemia in patients with concurrent hypertension and obstructive sleep apnea (OSA). The aim of our study is to evaluate the effi...

La acromegalia o hipersomatotrofismo canino se caracteriza por una hipersecreción crónica de hormona del crecimiento (GH). Dicha hipersecreción de GH es inducida por la elevada progesteronemia que caracteriza a la fas...