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Abstract Cerebrospinal fluid metabolomics is a promising research technology in the elucidation of nervous system disorders. Therefore, in this work, a cerebrospinal fluid (CSF) metabolomics method using liquid chromatog...

Abstract A 15‐year‐old male castrated domestic shorthair cat presented with increasingly frequent vestibular episodes. The cat exhibited episodes of a head tilt, nystagmus, abnormal mental state, vocalizing, hypersal...

Abstract Background Epilepsy in dogs and humans is associated with blood‐brain barrier (BBB) dysfunction (BBBD), which may involve dysfunction of tight junction (TJ) proteins, matrix metalloproteases, and astrocytes. I...

Abstract Focal cortical dysplasia (FCD) is a predominant cause of drug-resistant epilepsy in children, yet the neuro-immune mechanisms underlying this condition are not well understood. Through transcriptomic screening c...

Abstract Background Hypothalamic phospholipids, essential components of neuronal membranes, play a key role in neuroendocrine regulation and synaptic plasticity. Liposom Forte, an injectable formulation based on hypothal...

O artigo apresenta uma breve revisão sobre os achados históricos, epidemiológicos, tratamento e perspectivas terapêuticas para as epilepsias, com enfoque na epilepsia do lobo temporal. Apresenta dados obtidos com est...

Abstract Epilepsy is a common neurological disorder giving rise to both recurrent and spontaneous seizures as well as additional neurological comorbidities. In approximately 30% of patients, seizures are not ameliorated ...

Epilepsy is a common neurological disorder which affects 50 million people worldwide. Patients with epilepsy may present cognitive deficits and psychological impairment. Currently, 30% of patients fail to respond to any ...

Abstract Epilepsy, characterized by abnormal neuronal hyperexcitability and disrupted ion homeostasis, increasingly appears to involve complex neuron–glia interactions. This study develops a three-compartment computati...

Epilepsy is a debilitating neurological disorder characterized by recurrent seizures, affecting millions of patients worldwide. Retrospective studies in temporal lobe epilepsy (TLE) patients have shown a high incidence o...

Asparagine-linked glycosylation 13 homolog (ALG13) encodes a nonredundant, highly conserved, X-linked uridine diphosphate (UDP)-N-acetylglucosaminyltransferase required for the synthesis of lipid linked oligosaccharide p...

Abstract Case Description We describe a case of presumptive acquired systemic lupus erythematosus secondary to phenobarbital administration in a dog, which resolved with withdrawal of the drug. Clinical Findings A 3.5 ...

Abstract Background Neurofilament light chain (NfL) is released into the peripheral circulation by damaged axons. Objectives To evaluate the diagnostic value of serum NfL concentration in dogs with intracranial diseases....

Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of ex...

Este depoimento representa mais uma lição de vida que um estudo teórico. Os três anos de trabalho voluntário na Associação dos Portadores de Epilepsia de Minas Gerais me permitiram conhecer e assistir a alguns por...

Abstract Purpose MELD Graph is a state-of-the-art artificial intelligence (AI) model for automated detection of focal cortical dysplasia (FCD), but its performance remains limited, highlighting the need to investigate wh...

A 22 year-old-male was admitted with macroscopic hematuria. He had a diagnosis of tuberous sclerosis complex (TSC). On physical examination, angiofibromas were observed in the nasolabial folds and hypomelanotic macules w...

Abstract Background Shaking puppy syndrome is commonly attributed to abnormal myelination of the central nervous system. Hypothesis/Objectives To report the long‐term clinical course and the imaging characteristics of ...

Background Antiseizure medications (ASMs) are the standard treatment for epilepsy. Yet because ASMs can have adverse effects and seizure risk decreases with longer seizure-free periods, guidelines have suggested consider...

Abstract Background Weyers acrofacial dysostosis (WAD) is a rare autosomal dominant ciliopathy caused by heterozygous pathogenic variants in the EVC2 gene. The classic phenotype includes short stature, dental anomalies, ...

Abstract Epilepsy is a chronic neurological disease that profoundly impacts patients’ daily lives. Electroencephalography (EEG) serves as a crucial tool for the clinical diagnosis of epilepsy and other brain disorders....

Las crisis atónicas focales son poco reconocidas como fenómenos ictales, pueden corresponder tanto a una epilepsia generalizada como a una epilepsia focal. Las áreas del cerebro implicadas en la gestión de este tipo ...