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Abstract Background Population ageing presents increasing challenges for health systems. Identifying complex needs and planning individualized care through Comprehensive Geriatric Assessment (CGA), promoting intergenerat...

Abstract Background Adverse events across the lifespan have been linked to poorer health outcomes, but the biological mechanisms remain unclear. The aim of this study was to quantify the independent and joint association...

Aims: Preoperative education is routinely integrated into enhanced recovery pathways for hip and knee arthroplasty, yet its independent effect on early outcomes remains uncertain. This study examined whether completion o...

Abstract Introduction The ageing of the population is expected to increase the costs and consumption of health care. Care should be patient-centred. Patient-centred care (PCC) has been shown to increase the quality of li...

Abstract Introduction As the population ages, non–ST-segment elevation myocardial infarction (NSTEMI) in the oldest-old poses unique management challenges, yet this group remains underrepresented in clinical trials. He...

IntroductionFamilial partial lipodystrophy (FPL) is a rare condition related to partial deficiency of adipose tissue and consequent insulin resistance resulting in metabolic alterations. Although type 2 diabetes mellitus...

Abstract Background Sarcopenia, the age-related loss of muscle mass and strength, is a leading cause of disability and frailty in older adults. Though primarily seen as a musculoskeletal condition, emerging evidence sugg...

Background People with schizophrenia have a high premature mortality risk. Obesity is a key potential underlying risk factor that is relatively unevaluated to date.Aims In this study, we investigated the associations of ...

Abstract Treatment decisions in cancer care can be life-critical and significantly affect self-determination concerns. Therefore, it is of great importance that the decision-making process is set up in the interest and s...

Abstract Background Physical exercise has emerged as a promising non-pharmacological approach for improving cognitive and physical function in older adults with mild cognitive impairment (MCI). However, most existing int...

Abstract Background Frailty, social isolation, loneliness, and poverty may render older adults vulnerable to social or health stressors. It is imperative to identify effective interventions to address them especially in ...

Abstract Sarcopenia, the age-related muscle atrophy, is a serious concern as it is associated with frailty, reduced physical functions, and increased mortality risk. Protein supplementation is essential for preserving mu...

BackgroundKinesiophobia is a significant psychological factor that affects early ambulation in postoperative patients. It is particularly common after radiofrequency ablation for atrial fibrillation. Nonetheless, few stu...

BackgroundCholangiocarcinoma (CCA) carries a dismal prognosis. Beyond clinical determinants, socioeconomic deprivation may also influence outcomes. Busan, a rapidly aging metropolitan area in Korea, provides a critical s...

Abstract Introduction The geriatric population is the fastest-growing age group and accounts for one-third of surgical patients. A growing body of evidence reveals that postoperative cognitive dysfunction (POCD) is the m...

Abstract Intrinsic capacity is a concept established by the World Health Organization (WHO). The concept aims to represent the total of a person’s physical and mental abilities, measured across five domains: cognition,...

Background: Adults aged 75 years and older carry the highest absolute risk of cardiovascular disease (CVD) yet remain substantially underrepresented in randomized trials evaluating statin therapy for primary prevention. ...

ABSTRACT Background Physical exercise is recommended for sarcopenia prevention and treatment. Patients with frailty often show poor tolerance. To achieve universal availability, electrical stimulation of skeletal muscles...

Abstract Background Diabetes is associated with a high incidence of diabetic foot and peripheral artery disease and with markedly increased lifetime amputation risk. Here we investigated predictors of reamputation risk a...

Chen Luo,1,2 Yuhan Jiang,1,2 Huiling Yan,2 Kan Sun,3 Wentao Li,3 Mengqing Cao,2 Lijun Zhu,2 Xing Hu,2 Juan Tong,2 Changcheng Zheng1– 3 1Department of Internal Medicine, Graduate School of WanNan Medical College, Wuhu, ...

Abstract N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA and plays a crucial role in post-transcriptional gene regulation. Recent studies have revealed that m6A modification is dysr...

Abstract Lebanon is frequently referred to as a model of a plural and stable democracy in the Middle East: a multi-ethnic and pluri-religious society that guarantees political representation through a power-sharing confe...

Abstract Background Sarcopenia, altered bone and systemic metabolism, physical frailty and cognitive decline are age-dependent and interrelated phenomena. Sleep disorders which are erroneously considered as part of the a...

Ageing, immobilization, sepsis or cachexia reduce muscle mass and function. The age-related loss, i.e. sarcopenia, contributes to frailty and results in a loss of mobility and autonomy in aging and disease. Affected ind...