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Trypanosoma cruzi, the etiological agent of Chagas disease, has a digenetic life cycle. In itspassage from the insect vector to the mammalian host, and vice versa, it must be preparedto cope with abrupt changes in enviro...

Abstract Androgen receptor (AR) is a therapeutic target for prostate cancer. Despite effectively targeting its folded ligand-binding domain (LBD), resistance ultimately develops by mechanisms involving reactivation of AR...

Abstract. During each voyage, the vessel's traction capacity decreases due to the gradual degradation of the characteristics of the propulsion complex. This process is influenced by factors such as fouling of the vessel'...

L-arginine (ARG) availability is a critical determinant of macrophage antimicrobial capacity, as it fuels nitric oxide production and other immune effector pathways essential for restricting Mycobacterium tuberculosis (M...

Yue Hu,1,2 Peichen Xie,2 Jialin Li,2 Rui Liu,2 Haotong Wang,2 Zhicheng Wang,2 Chunyan Liu1 1Department of Radiology, The Second Hospital of Jilin University, Changchun, People’s Republic of China; 2NHC Key Laboratory o...

Aging is characterized by measurable reductions in tissue repair, immune balance, and metabolic regulation. Increasing evidence suggests that these changes may arise, in part, from an insufficiency or altered quality of ...

Background: Cancer stem cells are important for the development of many solid tumors. These cells receive promoting and inhibitory signals that depend on the nature of their environment (their niche) and determine cell d...

Ingeniero Industrial Universidad Nacional de La Plata Facultad de Ingeniería

"This thesis evaluates the technical, economic and environmental performance of a hydrogen fueled hybrid bus, which uses an internal combustion engine as a power unit. Results are compared to those of a conventional dies...

The usage of hydrogen in fuel cells gains more and more importance due to the need for emission-low alternatives in various technical areas. The focus of this work lies on the polymer electrolyte membrane fuel cell. One ...

Atualmente, o tratamento no combate ao vírus HIV é baseado na inibição das enzimas necessárias à sua replicação nas células infectadas. Comumente, uma combinação de medicamentos, capazes de inibir as enzimas...