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Abstract Pathogenic variants in CYFIP2 cause developmental and epileptic encephalopathy 65 (DEE65) and have been predominantly investigated in the context of central nervous system dysfunction. However, emerging clinical...

Abstract Background Anti-amyloid monoclonal antibodies are entering clinical practice for early symptomatic Alzheimer’s disease (AD), but European real-world data on feasibility, safety, and biomarker monitoring remain...

Abstract IgG4-related disease (IgG4-RD) is a systemic inflammatory condition marked by tissue infiltration of IgG4-positive plasma cells, often resulting in fibrosis. While IgG4-RD commonly affects organs such as the pan...

Abstract Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) characterized by multifocal inflammation and axonal degeneration, driven by innate and adaptive immune cells. Th...

Abstract Background Triggering receptor expressed on myeloid cell-2 (TREM2) signaling promotes disease-associated microglia (DAM) and phagocytosis in neurodegenerative diseases. Traditional anti-TREM2 agonist antibodies ...

BackgroundCurrent prognostic models for cerebral venous sinus thrombosis (CVST) inadequately predict long-term cognitive and functional outcomes, focusing primarily on survival. We aimed to develop and validate a simple,...

Abstract Involvement of the complement system in myasthenia gravis (MG) depends on the IgG subclass of the mediating antibody. LRP4 antibodies (LRP4-ab) are typically of the IgG1 or IgG2 subclass, implying distinct capac...

Abstract Objective To investigate the associations between thrombus Matrix Metalloproteinase-9 (MMP-9) level and the systemic inflammatory characteristics in patients with Acute Ischemic Stroke (AIS), and to evaluate the...

BackgroundIntracranial infection (ICI) is a serious complication following spontaneous intracerebral hemorrhage (ICH) and is associated with prolonged intensive care, increased morbidity, and poor functional outcomes. Ea...

The precise treatment and dynamic management of traumatic brain injury pose a substantial challenge to the global healthcare sector. This challenge arises not only from the complex and dynamically evolving pathological m...

BackgroundRepetitive peripheral magnetic stimulation (rPMS), a representative non-invasive neuromodulation technique, is widely utilized for the recovery of motor dysfunction following stroke. Although its clinical effic...

BackgroundPeople with Parkinson’s Disease (PD) treated with dopamine agonists are at increased risk for developing impaired impulse control behavior. It has been suggested that patients tend to underreport problems wit...

External ventricular drain (EVD) placement is a standard neurosurgical procedure for cerebrospinal fluid diversion and intracranial pressure monitoring, yet conventional freehand techniques are associated with substantia...

Post-stroke cognitive impairment (PSCI) has garnered widespread attention due to its high incidence and its association with increased risk of stroke recurrence and mortality. Growing evidence indicates that early predic...

Abstract The genomic locus that encodes the Leucine-rich repeat kinase 2 (LRRK2) gene is highly pleiotropic and associated with Parkinson’s disease (PD). Coding variants associated with risk of PD act as gain of functi...

BackgroundFibromyalgia affects 2%–8% of the global population with suboptimal treatment outcomes. Emerging evidence suggests histamine intolerance, mediated by diamine oxidase (DAO) deficiency, may contribute to fibrom...

Early detection of Parkinson’s disease (PD) through speech analysis offers significant clinical advantages, yet no validated tools exist for Arabic-speaking populations, representing a critical gap in global healthcare...

ObjectiveTo systematically map the evolution, academic network structure, and emergent research fronts of functional magnetic resonance imaging (fMRI) applications in prolonged disorders of consciousness (pDoC) through b...

Abstract Background Tauopathies are a group of neurodegenerative diseases, including Alzheimer’s disease (AD), characterized by progressive accumulation of pathological Tau proteins. Among the diverse Tau species, trun...

IntroductionPolyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis affecting medium-sized vessels. While peripheral neuropathy occurs in 50–75% of patients, cranial nerve involvement is exceptionally rare...

ObjectiveTo systematically evaluate the prevalence of anxiety and depression among young stroke patients and their associated factors using a meta-analysis.MethodsIn this review, young stroke was defined as stroke occurr...

Abstract Neuroimmunological diseases arise from a complex interplay of genetic susceptibility, environmental exposures, and immune-mediated mechanisms. In this context, modifiable lifestyle and environmental factors may ...

BackgroundPaclitaxel-induced peripheral neuropathy (PIPN) significantly impairs the quality of life of cancer survivors. A systematic visualization of global research trends in this domain is currently lacking.ObjectiveT...

Abstract Ventricular shunt catheters are the standard of care for managing hydrocephalus, yet 40% of implanted catheters fail within two years of implantation, mainly due to proximal catheter obstruction. Prior literatur...