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Abstract Background Current understanding of the fluid biomarker profile in early-onset Alzheimer’s disease (EOAD) associated with pathogenic APP variants remains limited. We characterized four EOAD pedigrees carrying ...

Materias / palabras clave: efficacy; magnetic resonance-guided focused ultrasound surgery (MRgFUS); Parkinson; safety; SRMA

Abstract Objective To investigate the associations between thrombus Matrix Metalloproteinase-9 (MMP-9) level and the systemic inflammatory characteristics in patients with Acute Ischemic Stroke (AIS), and to evaluate the...

Abstract Background Patients with hypermobile Ehlers-Danlos Syndrome (hEDS) are at risk of developing craniocervical instability (CCI). Iatrogenic causes of CCI in hEDS are underreported. We describe a case series of hED...

BackgroundIntracranial infection (ICI) is a serious complication following spontaneous intracerebral hemorrhage (ICH) and is associated with prolonged intensive care, increased morbidity, and poor functional outcomes. Ea...

Abstract Background Plasma glial fibrillary acidic protein (GFAP) has emerged as a promising biomarker of astrocytic reactivity in preclinical Alzheimer´s Disease (AD). However, most evidence to date comes from ultrasen...

BackgroundDiscrepancies in symptom concerns and the perceived burden among individuals with Parkinson's disease (PD), their caregivers, and their physicians can hinder effective care.ObjectivesWe investigated differences...

The precise treatment and dynamic management of traumatic brain injury pose a substantial challenge to the global healthcare sector. This challenge arises not only from the complex and dynamically evolving pathological m...

Materias / palabras clave: arterial dissection; histopathology; management; outcome; revascularization

Materias / palabras clave: rare disorders; neurodevelopment; sleep disorder; wearables; sleep architecture

Materias / palabras clave: biomarkers; molecular regulation; neural stem cells; neuroplasticity; neurorehabilitation; regenerative medicine

Spinal cord injury (SCI) triggers a cascade of primary and secondary pathological events that culminate in the formation of glial and fibrotic scars, which constitute a major barrier to axonal regeneration and functional...

ObjectiveTo evaluate the efficacy and safety of skull base-peripheral (SBP) acupuncture in patients with post-stroke cognitive impairment (PSCI).MethodsWe searched eight Chinese and English databases from inception to Ju...

BackgroundUpper limb motor dysfunction is common after stroke and substantially restricts independence. Robot-assisted training (RAT) and blood flow restriction training (BFRT) have individually demonstrated potential be...

BackgroundRepetitive peripheral magnetic stimulation (rPMS), a representative non-invasive neuromodulation technique, is widely utilized for the recovery of motor dysfunction following stroke. Although its clinical effic...

BackgroundEarly and effective intervention is crucial in the management of acute ischemic stroke (AIS) without large- or medium-vessel occlusion (non-LVO/MVO), which accounts for approximately 60–70% of all AIS cases. ...

Abstract Background Ischemic stroke (IS) remains a leading cause of death and disability worldwide. Stroke–heart syndrome, triggered by acute cerebral ischemia, causes autonomic dysfunction that can result in myocardia...

BackgroundPeople with Parkinson’s Disease (PD) treated with dopamine agonists are at increased risk for developing impaired impulse control behavior. It has been suggested that patients tend to underreport problems wit...

AimsElectroacupuncture (EA) promotes the regeneration and repair of peripheral nerve injury (PNI) in clinical, and its underlying neuroimmune mechanisms have still not been fully clarified. Our study investigates the rol...

External ventricular drain (EVD) placement is a standard neurosurgical procedure for cerebrospinal fluid diversion and intracranial pressure monitoring, yet conventional freehand techniques are associated with substantia...

Abstract Background Pulmonary cryptococcosis (PC) is increasingly diagnosed in human immunodeficiency virus (HIV)-negative and apparently immunocompetent individuals. A critical complication of PC is dissemination to the...

Background/objectivesNeurofibromatosis type 1 (NF1) is a common genetic disorder often accompanied by cognitive, behavioral, and neurodevelopmental disorders. While tumor-related manifestations are well-documented, less ...

ObjectiveIn the present study, we established a rat model of optic nerve injury to evaluate whether direct local delivery of neurotrophic agents following traumatic optic neuropathy (TON) enhances retinal ganglion cells ...

Background Acute ischaemic stroke often leads to significant disability and mortality. Secondary brain injury caused by post-stroke immune and inflammatory responses worsens outcomes.Aim To assess the efficacy and safety...