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Uric acid is a final product of purine metabolism, and its concentration in the blood serum of healthy individuals is 3–7 mg/dl. Hyperuricemia is associated with higher cardiovascular risk, and its prevalence related t...

Psychological factors play an important role in aggravating skin diseases, which could lead to increasing the severity of skin diseases, such as psoriasis, atopic dermatitis, acne vulgaris, seborrheic dermatitis, and lic...

The association between cheese consumption and chronic inflammatory skin conditions remains unclear. We used a two-sample bidirectional Mendelian randomization (MR) framework to investigate the genetic causality between ...

Psoriasis is a chronic and recurrent skin disease, affecting 1.5-3% of thepopulation. It is characterized by abnormal epidermal proliferation,immunological disturbances with predominance of Th1 response andcomplex pathog...

Materias / palabras clave: anti-TNF therapy; psoriasis; resistance in therapy; molecular marker

Materias / palabras clave: subcorneal pustular dermatosis; sneddon-wilkinson syndrome; iga pemphigus; pustular psoriasis

ABSTRACT Background and Aims Familial Mediterranean Fever (FMF) is a monogenic autoinflammatory disease caused by mutations in the MEFV gene, resulting in recurrent inflammatory episodes and a risk of developing amyloido...

Immune dysregulation can lead to autoimmunity and autoinflammation. The goal of treatment is to balance targeted therapies while avoiding infections or other side effects, which becomes complicated with multiple diagnose...

BackgroundItchy E3 ubiquitin ligase deficiency (ITCH deficiency) is a rare monogenic immune dysregulation syndrome characterized by early-onset multisystem autoimmunity and significant morbidity and mortality. Only one p...

Abstract IL-22, a signature cytokine for type 3 lymphoid cells, including T helper 17/22 (Th17/22) and type 3 innate lymphoid cells (ILC3), mediates epithelial homeostasis and protective pathogen responses in barrier tis...

Abstract Background Autoimmune conditions are common in women of reproductive age. They are associated with an increased risk of adverse pregnancy outcomes; whether this is causal is unclear. Our aim was to explore the c...

Cutaneous lymphatic vessels are essential for maintaining tissue homeostasis and coordinating immune defence, making them vital to skin health. Recent advances in molecular biology and immunology have revealed the associ...

IntroductionSchnitzler syndrome (SchS) is a rare, late-onset, acquired autoinflammatory disorder characterized by recurrent urticarial lesions, monoclonal gammopathy and systemic inflammation. Although interleukin-1 (IL-...

Metformin is the most widely used oral antidiabetic drug in the world. It is the first-line drug in type 2 diabetes, where its inhibiting effect on hepatic glucose production, increasing muscle and adipose tissue insulin...

Abstract Autoimmune diseases (AIDs) result from intricate interactions among genetic, environmental and immune factors, with emerging evidence underscoring the role of the central nervous system (CNS) in their pathogenes...

We report a previously healthy 4-year-old female presenting with a diffuse, recurrent, pruritic, erythematous rash involving the entire body with eight episodes over 2 years, each lasting 7–10 days. The rash reliably a...

Introduction . Progressive macular hypomelanosis (PMH) is a cutaneous pigmentary disorder resulting from a deficit of melanin and manifesting with disseminated hypopigmented macules. Pityriasis alba, post-inflammatory hy...

Pustular rosacea is a rare chronic inflammatory disease whose prevalence increases with age. We report a case of an 8-year-old patient who presented with a 3-year history of recurrent papulopustular facial eruptions asso...

BackgroundCOPA syndrome is a rare autosomal-dominant immune dysregulation disorder caused by pathogenic variants in the COPA gene, typically presenting with autoimmunity, arthritis, and interstitial lung disease. However...

Vitiligo is a quite frequently occurring skin disease. Although it does not cause any pain or internal organ damage, it constitutes a significant cosmetic problem having a significant impact on quality of life. A number ...

Los tratamientos antipsoriásicos utilizando antralina presentan varias desventajas debido principalmente a las propiedades físico-químicas de ésta, a sus efectos adversos y a su formulación. La antralina es insolub...