Buscar recursos académicos

O trabalho foi realizado com o objetivo de se avaliarem as características morfogênicas e estruturais de Brachiaria brizantha cv. Xaraés, submetido a quatro doses de nitrogênio (0, 40, 80 e 120 mg/dm³) e três regim...

Aberrant DNA methylation observed in cancer can provide survival benefits to cells by silencing genes essential for anti-tumor activity. DNA-demethylating agents such as Decitabine (DAC)/Azacitidine (AZA) activate otherw...

The kiwifruit (Actinidia chinensis var chinensis cv. Hayward), a climacteric fruit, can be harvested at physiological maturity and maintain its quality for up to six months at cold storage. The length of the storage peri...

Abstract Background Immunological non-responders (INR), distinguished by profound immune dysfunction, fail to achieve immune reconstitution despite receiving antiretroviral therapy (ART). INR experience lower life expect...

Background: Intrahepatic cholangiocarcinoma (ICC) is an aggressive hepatobiliary malignancy characterized by a complex pathogenesis and poor prognosis. Telomere dysfunction and cellular senescence are involved in the pat...

Micronutrients serve as critical metabolic sensors and epigenetic regulators that orchestrate cytokine production through multiple overlapping signalling cascades, transcriptional networks, and cellular metabolic states....

Efforts are made to produce superior seeds and pest and disease resistance through variety assembly. Characterization produces information that is used in planning the creation of melon plants as desired. This study aims...

Lipopolysaccharide (LPS) triggers signal transduction in dental pulp cells (DPCs), leading to various biological events. The present study described the biological response of DPCs to LPS, aiming to provide a deeper unde...

The objective of this work was to evaluate the morphogenetic and structural characteristics of xaraes palisadegrass submitted to three cutting heights (15, 20 and 25 cm) when the sward reached 95% of light interception d...

Key Points. Understanding how heme proteins/heme induce AKI and whether NAD+-boosting ameliorates heme protein–mediated AKI is clinically relevant. Heme proteins/heme directly decrease kidney NAD+ content and NAD+-boos...

BackgroundGranulomatous-lymphocytic interstitial lung disease (GLILD) is a major cause of morbidity and mortality in common variable immunodeficiency (CVID), yet its pathophysiology remains incompletely understood, and n...

The phloem transport of amino acids is a key step in the efficient use of nitrogen (N). Despite the importance of this issue, little information is known about the regulation of phloem transport of amino acids in plants ...

Ultraviolet (UV) radiation has been considered a deleterious agent that living organisms must avoid. However, many of the acclimation changes elicited by UV induce a wide range of positive effects in plant physiology thr...

The objective of the present trial was to evaluate the productive and morphogenetic characteristics of buffel grass subjected to different air temperatures and CO2 concentrations. Three cultivars of buffel grass (Biloela...

Abstract Senescent cells (SnCs) are increasingly recognized as key contributors to osteoarthritis, with conventional strategies centered on their elimination. However, senolytic approaches face mounting limitations, driv...

Abstract Background Mesenchymal stromal cells (MSCs) are widely used in regenerative medicine, but their clinical utility is limited by replicative senescence. Strategies that reverse aging while maintaining MSC identity...

Hematopoietic stem cells (HSCs) sustain physiological hematopoiesis by generating all hematopoietic cells. However, the connection between HSC stemness/activities and organismal lifespan, especially under stress, remains...

Background: Periodontitis combined with orthodontic treatment creates a complex inflammatory and biomechanical microenvironment in gingival tissue, where macrophages play pivotal roles in tissue remodeling and immune reg...

Abstract Osteoarthritis is an aging-related systemic disease involving the crosstalk of multiple organs/tissues in metabolism and inflammation, yet little is known about the contribution of liver and marrow adipose tissu...

The senescence of the neuro-skeletal muscle system is typified by a gradual deterioration in muscle mass, strength, neuromuscular efficacy, and cognitive capabilities, which is further exacerbated by metabolic dysregulat...

La telomerasa es la enzima responsable del mantenimiento de la longitud de los telómeros mediante la adición de secuencias repetitivas ricas en guanina, y su actividad se observa principalmente en gametos, células mad...

Telomeres are highly regulated and dynamic complexes that protect the genomic DNA and prevent the end of linear chromosomes from being misrecognized as a broken DNA. Due to the end replication problem, telomeres of somat...

ABSTRACT Background Intervertebral disc degeneration (IVDD), a prevalent spinal disorder, is closely associated with abnormal mechanical stress. The nucleus pulposus (NP), annulus fibrosus (AF), and cartilaginous endplat...

Abstract Aging is a primary risk factor for chronic diseases, with cellular senescence as an effective target to delay, prevent or alleviate age-related disorders. Here we report in vitro screening outputs from a natural...