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IntroductionOSMR encodes oncostatin M receptor beta (OSMRβ), a cell surface receptor of the gp130 family that binds OSM and IL-31, and is highly expressed on fibroblasts. The gp130 family comprises signaling proteins, m...

Ethnopharmacological relevance This article presents the results of a study on wild plant pharmacopeia and medical ethnobotany of the Wichí people of the South American Gran Chaco region, where native forest still persi...

BackgroundNewborn screening for severe combined immunodeficiency (SCID) using T cell receptor excision circles (TRECs) enables early detection of disorders affecting T cell development. While low TRECs typically indicate...

BackgroundTelomere biology disorders (TBD) are rare multisystem disorders characterized by a wide array of clinical presentations, including bone marrow failure, pulmonary fibrosis, and malignancy predisposition due to p...

POEMS syndrome is a rare multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal protein (M-protein) secretion, and skin changes. Its pathogenesis is driven by plasma cell dyscrasia...

As a broad-spectrum preservative， sodium dehydroacetate（DHA-S） was once used in a variety of foods. However， with the systematic research on its toxic effects， the potential threats to human health posed by DHA...

Raynaud’s phenomenon is one of the most common disorders of the blood vessels, which usually affects fingers and toes. Raynaud’s disease, also called primary Raynaud’s phenomenon, is diagnosed when the cause is unk...

CARMIL2 is a protein required for T cell activation, specifically for CD28 and CARMA-1/PKC coupling and NF-kB signaling. CARMIL2 deficiency has pleiotropic presentations, which can include recurrent viral and mucocutaneo...

Rosacea is a chronic inflammatory skin disorder primarily characterized by persistent facial erythema, episodic flushing, papules and pustules, as well as phymatous changes. Despite extensive research, the pathogenesis o...

Introduction . Urticarial vasculitis is a subtype of cutaneous leukocytoclastic vasculitis. The disease often accompanies systemic disorders, including hematologic malignancies, connective tissue diseases, and infectious...

Perianal pruritus is an unpleasant cutaneous sensation that inducesscratching of the skin around the anal orifice. It is a common symptomin the course of many systemic, dermatological and proctological disorders.The diag...

El vitíligo es uno de los desórdenes más frecuentes de hipopigmentación de la piel caracterizado por manchas de color blanco rosáceo, desprovistas de melanocitos identificables. El vitíligo resulta de una compleja ...

Las afecciones dermatológicas poseen una alta incidencia en la atención primaria de salud cubana. Esta incidencia varía en relación con la etiología, principalmente las micosis, las afecciones virales y bacterianas,...

Himatanthus sucuuba (Spruce) Woodson é uma planta amazônica conhecida popularmente como sucuuba. É uma árvore latescente de tronco ereto e casca rugosa. A população utiliza o látex topicamente contra afecções de...