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Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is an enzyme that plays a pivotal role in DNA repair and the maintenance of genomic stability. The discovery of synthetic lethality in tumors with homologous recombination...

Proteolysis-targeting chimeras (PROTACs) have emerged as a promising therapeutic modality and now represent an important addition to the toolkit of medicinal chemists. Compared with conventional small-molecule inhibitors...

Abstract Background Lavandula stoechas L., commonly known as lavender, has been traditionally used in various therapeutic applications, including as a smoking cessation aid. The aim of this study was to investigate the a...

Abstract Nitrogen-doped carbon dots (CDs) were prepared from essential fluorescent amino acids, such as lysine (Lys), phenylalanine (Phe), tyrosine (Tyr), and tryptophan (Trp) by two routes, microwave and teflon-lined au...

IntroductionSTING-associated vasculopathy with onset in infancy (SAVI) is a rare, severe type I interferonopathy caused by gain-of-function mutations in STING1, leading to early-onset systemic inflammation, cutaneous vas...

To induce new bone formation, mesenchymal stem cells were seeded onto atelocollagen honeycomb scaffold. We evaluated the efficacy of this scaffold combined with KUSA/A1 cells in vivo. KUSA/A1 cells alone and with ateloco...

Background: Repetitive Peripheral Magnetic Stimulation (rPMS) is an innovative neuromodulation technique that has gained attention for its potential therapeutic effects in both musculoskeletal and neurological disorders....

Abstract Fatty acid ethanolamides (FAEs) are bioactive lipids with amphiphilic properties and potential as prodrugs. In this study, a homologous series of FAEs (C8:0–C18:0) was evaluated for solubility, hydrophobicity,...

Abstract Background The tumor immune microenvironment (TIME) of canine and feline mammary carcinomas (CMC and FMC) comprises a complex collection of immune cells that remains underinvestigated. We performed extensive imm...

Secondary metabolites in the medicinal plant Gynura procumbens have various beneficial pharmacological activities. However, the limited availability of these beneficial compounds has constrained the possibilities for the...

Mifepristone (RU-486), the first clinically effective progesterone antagonist, was initially identified as having antiglucocorticoid activity. Although early interest focused on its role as a glucocorticoid receptor anta...

We report a technology to form human embryoid bodies (hEBs) from singularized human embryonic stem cells (hESCs) without the use of the p160 rho-associated coiled-coil kinase inhibitor (ROCKi) or centrifugation (spin). h...

Abstract Parasitic diseases such as malaria, leishmaniasis, and schistosomiasis remain difficult to treat due to the pathogens’ complex life cycles, intracellular niches, and resistance to conventional therapies. Tradi...

Oxidative stress caused by free radicals is a key contributor to the development of chronic diseases. As a natural defense strategy, the identification of plant-based free radical scavengers has become increasingly impor...

Type 2 diabetes mellitus (T2DM) is characterized by chronic metabolic dysfunction and low-grade inflammation. This study aimed to identify inflammation-associated molecular targets in T2DM and to computationally evaluate...

Abstract Background Interventional radiology (IR) and interventional endoscopy (IE) have broad potential for minimally invasive therapy in veterinary patients, but the scope of original peer‐reviewed veterinary IR/IE r...

The complex etiology and short-term positive effects of treatments for osteoarthritis (OA) remain a significant challenge globally. The lack of approved disease-modifying OA drugs (DMOADs) and the rapid clearance of intr...

Abstract Advances in artificial intelligence (AI) and multi-omics integration are reshaping precision oncology by enabling deeper mechanistic understanding, improved characterization of tumor heterogeneity, and the accel...

Abstract Background The therapeutic efficacy of programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) inhibitors in lung cancer management remains suboptimal. Sporoderm-removed Ganoderma Lucidum Spore Pow...

The characteristic oral environment – with its dynamic clearance, moisture, microbial load, and inflammatory potential – makes oral diseases highly prevalent and therapeutically challenging. Metal-organic frameworks ...

Peili Jin,1,2 Chuanchuan He,3 Xiaojuan Zhang,1 Yimin Huang3 1College of Medicine, Jiaxing University, Jiaxing, People’s Republic of China; 2Department of Pediatric, Jiaxing Maternity and Child Health Care Hospital, Aff...

ABSTRACT Background and Aims De novo drug design is the process of generating novel lead compounds that possess desirable pharmacological activities and optimal physicochemical properties for therapeutic development. In ...

BackgroundArtificial intelligence (AI) has substantial potential to advance periodontal and peri- implant care through novel diagnostic, prognostic, and therapeutic opportunities. Nevertheless, the evidence is scattered ...

ABSTRACT Background Anticoagulation therapy is central to the prevention of thromboembolic disorders but is limited by bleeding complications associated with traditional agents such as warfarin and direct oral anticoagul...