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BackgroundSevere alopecia areata in children is difficult to treat, and conventional therapies often show limited efficacy and substantial adverse effects. Dupilumab has shown potential in patients with alopecia areata a...

IntroductionCyclin-dependent kinase 5 (Cdk5) plays a critical role in pain transmission by phosphorylating key nociceptive proteins. One of its recently identified substrates, the P2X2 subunit, is part of the P2X2/3 puri...

IntroductionChronic spontaneous urticaria (CSU) is a clinical diagnosis managed according to American Academy of Allergy, Asthma & Immunology (AAAAI) and the American College of Allergy, Asthma & Immunology (ACAAI) guide...

The increasing integration of inverter-interfaced renewable energy sources has significantly changed the dynamic characteristics of modern power systems, resulting in a substantial decline in effective system inertia and...

The lung, and more specifically the airway epithelium, is continuously exposed to a wide range of inhaled environmental agents. Acting as a frontline physical and biochemical barrier, the airway epithelium orchestrates e...

Abstract Background Denervation triggers dramatic atrophy of skeletal muscle, accompanied by synaptic, contractile and metabolic changes. Several factors were shown to contribute to genetic reprogramming and proteostasis...

Abstract Background Endothelial cells (ECs) orchestrate vascular homeostasis and resilience but can undergo reprogramming into a mesenchymal-like phenotype through an endothelial-to-mesenchymal transition (EndMT). Crucia...

Waterlogging is a severe stress that constrains crop production. We studied ecophysiological traits related to waterlogging tolerance in wheat, barley oilseed rape and field pea. Outdoor experiments using canopies of whe...

Abstract Background Furosemide, a commonly used diuretic, activates the renin‐angiotensin‐aldosterone system (RAAS) in other species. Little is known about RAAS peptide activation in horses. Hypothesis/Objectives To ...

The detection of high impedance faults (HIFs) plays a crucial role in modern active distribution systems to prevent risks like equipment failures, fire incidents, and disruptions in service, while maintaining a stable po...

Abstract This paper presents an effective approach for lower-order (LO) modeling of an electric vehicle–integrated off-grid microgrid (OMG) system. The seventh-order system (SOS) of the OMG is reduced to a second-order...

Grain sorghum [Sorghum bicolor (L) moench] exhibits intraspecificvariability for the rate of dormancy release and pre-harvest sprouting behavior. Two inbred lines with contrasting sprouting response were compared: IS9530...

Abstract The 14 October 2023 annular solar eclipse was visible from the US Pacific coast to Brazil's east coast. NASA's Global‐scale Observations of Limb and Disk (GOLD) mission observed the first synoptic thermospheri...

Forkhead box P3 (FOXP3) is the master transcription factor of regulatory T cells (Tregs) and is essential for maintaining immune tolerance. FOXP3 is stably expressed in Tregs, driving their suppressive function, and it i...

Microplastic (MP) contamination in agricultural soils is an emerging environmental hazard with poorly understood impacts on crops. Here, we investigated concentration-dependent effects of polyethylene MPs on tomato (Sola...

Abstract Background Interactions between SARS-CoV-2, influenza virus, and respiratory syncytial virus (RSV) at the population level remain poorly understood. This study aimed to quantify potential interactions among thes...

Abstract Small-cell lung cancer (SCLC) has long been characterized by its aggressive clinical course and a deceptive initial sensitivity to chemotherapy that almost invariably yields to recalcitrant disease. Recent genom...

IntroductionSchnitzler syndrome (SchS) is a rare, late-onset, acquired autoinflammatory disorder characterized by recurrent urticarial lesions, monoclonal gammopathy and systemic inflammation. Although interleukin-1 (IL-...

Melanopsin signaling within intrinsically photosensitive retinal ganglion cell (ipRGC) subtypes impacts a broad range of behaviors from circadian photoentrainment to conscious visual perception. Yet, how melanopsin photo...

BackgroundRecessive dystrophic epidermolysis bullosa (RDEB) is a devastating genodermatosis caused by biallelic COL7A1 mutations, where chronic inflammation drives disabling complications affecting quality of life and su...

The early postoperative period in infants following the correction of congenital heart defects is often accompanied by hemodynamic lability, systemic stress, and an acute-phase response, which may lead to transient organ...

The next generation of flat optic devices aspires to a dynamic control of the wavefront characteristics. Here, we theoretically investigated the reconfigurable capabilities of an epsilon-near-zero (ENZ) metasurface augme...

The present study evaluated the acute and subacute oral toxicities of a chloroform extract from Pseudomonas fluorescens DS17R in Wistar rats to support its safe application as a biocontrol agent. For acute toxicity asses...

BackgroundT cell–mediated hepatitis is an uncommon cause of acute pediatric liver injury. Most patients respond to steroids, but management of refractory disease remains challenging. We describe four patients with non-...