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Nimesulide was formulated as sustained release microcapsules using biodegradable polymer Poly(D,L-lactide-co-glycolide) (PLGA) as the release material by non-solvent addition coacervation method. The prepared microcaps...

El objetivo del este estudio fue el desarrollo y la caracterización del microesferas de etilcelulosa contiendo diclofenaco y la determinación del perfil de la liberación del fármaco in vitro. Las microesferas fueron ...

Devido à grande dificuldade de penetração de substâncias ativas através da pele, diferentes sistemas organizados, como os lipossomas, têm sido estudos com o objetivo de aumentar a penetração percutânea. O objeti...

The objective of the present investigation was to evaluate the potential of gellan gum- low molecular weight chitosan (GG-LMCH) polyelectrolyte complex (PEC) in the form of beads as prolonged release stomach specific flo...

"High-temperature renewable and industrial heat applications require efficient and compact solutions to address their inherent intermittency. Latent heat thermal energy storage is one such solution, acting as a buffer be...

Hydroquinone (HQ) is a drug reported to possess manifold biological activities. HQ is highly unstable into various topical vehicles, presenting low topical bioavailability and a relevant level of toxicity. The Pluronic®...

This work is focused on the development of a new particulate drug delivery system using sodium alginate (SA) and modified hydrophobic hydroxyl propyl methyl cellulose (HPMC, 60L grade) containing diclofenac as a model dr...

Para elaborar una forma sólida de administración oral a partir del extracto lipídico de las semillas de Cucurbita pepo L. usado en el tratamiento de la hiperplasia benigna prostática, la alternativa de la microencaps...

The present study involves the preparation of nimesulide-chitosan microparticles (NCM) as sustained delivery carriers with different polymer concentrations by pH change coacervation method using glutaraldehyde as cross-l...

The objective of the present work was to formulate chitosan nanoparticles as carriers for the lovastatin, since this drug undergoes extensive first pass extraction in the liver, and bioavailibity is low (< 5 %). Nanopart...

El objetivo del presente trabajo ha sido el de evaluar el efecto del peso molecular de acetobutirato de celulosa (ABC) (PM 30000 y 70000) y la presencia de polietilenglicol 1500 (PEG 1500) en el tamaño de microesferas p...

The objective of the present investigation was to investigate the effects of selected drugs (captopril and celecoxib) properties on different parameters drug entrapment, in vitro drug release, release pattern, in vitro d...

Oral route of drug administration is the most preferred route of drug administration but this route has its own limitations like pH of gastric media and controlling release rate of water soluble drug. To overcome these l...

The aim of this study was to formulate gliclazide loaded controlled release microspheres. Microspheres were prepared by quasi emulsion solvent diffusion technique using eudragit RLPO, eudragit RSPO and with their various...

The objective of present study was to improve gastric residence time of furazolidone by preparing mucoadhesive Multiple Unit Systems (MUS) with chitosan, Hydroxypropyl methyl cellulose K4M and sodium carboxymethyl cellul...

The purpose of this study was to design a novel vaginal delivery system composed of metronidazole microspheres dispersed within a bioadhesive gel. Microspheres were prepared by solvent evaporation method using Eudragit...

The present study involves development and investigation of liposomal system for improving skin residence of ciclopirox olamine in cutaneous mycosis. Spherical unilamellar liposomes of ciclopirox olamine were prepared ...

This study introduced a novel phase separation technique for the microencapsulation of metoprolol tartrate as a model. Non-solvent addition coacervation technique was employed for the loading of drug into ethylcellulose,...

Micropartículas contendo dexametasona foram preparadas através da secagem por aspersão de suspensão aquosa do fármaco e tensioativos (monoestearato de sorbitano e álcool polivinílico) e dois diferentes co-solvente...

Microspheres were prepared using the emulsion/solvent evaporation method with the aim of obtaining diclofenac sodium (DFS) prolonged release dosage forms. The effects of the drug:polymer ratio and addition of Pluronic F6...

The purpose of the present investigation was to prepare gellan-chitosan polyelectrolyte complex beads in one step and to explore the potential of the prepared beads in the oral delivery of metronidazole (log P = 0.0) and...

The goal of any drug delivery system is to provide a therapeutic amount of drug (s) to the proper site in the body in order to promptly achieve and there by to maintain the desired drug concentrations during treatment. T...

The present study involves preparation and characterization of floating multiparticulate microcapsules with Simvastatin as model drug for prolongation of gastric residence time. The main objective is to improve solubilit...

A camptotecina (CPT) é um fármaco de elevada atividade antitumoral cujo uso na terapêutica tem sido limitado devido a sua baixa solubilidade aquosa e elevada instabilidade após administração intravenosa. Buscando c...