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ABSTRACTThe objective of the present study is to evaluate the effects of plant extracts on growth performance, nutrient digestibility, and immune blood characteristics in growing pigs. A total of 80 [(Landrace × Yorkshi...

Abstract Purpose Triple-negative breast cancer (TNBC) displays an aggressive clinicopathological profile. Despite cytotoxic chemotherapy being the primary systemic therapy, complete responses are achieved in fewer than 3...

Thyroid hormones play a key role in adipose tissue development and function. Hypothyroidism (HypoT) can delay mammary tumor development in rats, possibly by altering mammary adipose tissue (MAT) and its interaction with ...

Abstract Age-dependent reproductive decline has become a significant global health concern as the average maternal age at first birth increases. Fertility loss associated with reproductive aging is driven in part by alte...

BackgroundNewborn screening for severe combined immunodeficiency (SCID) using T cell receptor excision circles (TRECs) enables early detection of disorders affecting T cell development. While low TRECs typically indicate...

Abstract Background DNA topoisomerase IIɑ (TOP2A) is crucial for maintaining genomic stability and is an important target for genotoxic chemotherapeutic drugs. STIP1 homology and U-box-containing protein 1 (STUB1) is a ...

BackgroundB cell Expansion with NF-κB Activation and T cell Anergy (BENTA) disease is a rare inborn error of immunity caused by gain-of-function (GOF) variants in CARD11. It is characterized by early-onset lymphadenopat...

Abstract Background Several cyanobacterial strains are known to contain a high number of genome copies and elevated cell cycle dynamics. We systematically investigated the ploidy of the model cyanobacterium Synechocystis...

Abstract Objective To investigate the influence of postoperative pathological factors (including variables not categorized as moderate - to - high - risk factors according to the Sedlis criteria) on the prognosis and lym...

Background and objectives: Tumors are complex systems characterized by variations across genetic, transcriptomic, phenotypic, and microenvironmental levels. This study introduced a novel framework for quantifying cancer ...

Background: Cancer stem cells are important for the development of many solid tumors. These cells receive promoting and inhibitory signals that depend on the nature of their environment (their niche) and determine cell d...

Growth and development of infants are crucial aspects that need to be regularly monitored, with height and weight serving as key indicators of nutritional status. This study aims to design and develop a technology-based ...

Abstract Rapid population growth and a corresponding increase in the demand for animal-derived proteins have led to food supply challenges and the need for alternative and sustainable meat production methods. Therefore, ...

Hexachlorobenzene (HCB) is a widespread environmental pollutant and a dioxin-like compound that binds weakly to the aryl hydrocarbon receptor (AhR). Because AhR and transforming growth factor β1 (TGF-β1) converge to re...

Abstract Background The therapeutic efficacy of programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) inhibitors in lung cancer management remains suboptimal. Sporoderm-removed Ganoderma Lucidum Spore Pow...

Abstract The primary objective of this study is to develop and validate robust data-driven models for accurately predicting bacterial growth inhibition induced by cerium oxide nanoparticles across different bacterial str...

IntroductionIn utero heat stress during late gestation impairs heifer growth and mammary development, reducing first-lactation productivity. However, whether these prenatal effects persist through the heifer’s first ge...

In this paper we investigated whether protein kinase C (PKC) b1 and PKCe, members of the classical and novel PKC family respectively, induce phenotypic alterations that could be associated with tumor progression and meta...

Abstract This study was designed to examine the effect of Lactilactobacillus curvatus LB-P9 on hair regeneration. The treatment of LB-P9 conditioned medium increased the proliferation of both hair follicle dermal papilla...

Cell morphological changes on HeLa cells after Curcuma longa etanolik extract exposure. Curcuma is mostly found in the areas with tropical and sub-tropical climate, and is one of original plants of Southeast Asia. In Ind...

ABSTRACT Background Skin cancer is one of the most prevalent malignancies worldwide, characterized by the abnormal growth of skin cells and significant clinical challenges. Conventional treatments—including surgery, ch...

Abstract Background As the most important plant-based protein ingredient in animal husbandry, soybean meal has become key focu in the feed industrym highlighting the need to reduce its inclusion rate and identify alterna...

Micronutrient undernutrition during critical periods of growth has become an important health issue in developing and developed countries, particularly among pregnant women and children having an imbalanced diet. Zinc is...

Abstract Background Tumor cells rely on enhanced glycolytic capacity to facilitate cell growth and progression. However, the molecular mechanisms governing glycolysis in triple-negative breast cancer (TNBC) remain largel...