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Cruzipain and Its Physiological Inhibitor, Chagasin, as a DNA-Based Therapeutic Vaccine Against Trypanosoma cruzi
Artículo
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Cruzipain and Its Physiological Inhibitor, Chagasin, as a DNA-Based Therapeutic Vaccine Against Trypanosoma cruzi
Cerny, Natacha et al · Frontiers Media S.A · 2020 · ISSN 1664-3224
Chagas disease caused by the protozoan parasite Trypanosoma cruzi is endemic in 21 Latin American countries and the southern United States and now is spreading into several other countries due to migration. Despite the e...
Idioma eng
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Delayed Diagnosis of DOCK8 Deficiency Unmasked by Tuberculoid Leprosy and JC Virus Infection
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Delayed Diagnosis of DOCK8 Deficiency Unmasked by Tuberculoid Leprosy and JC Virus Infection
Shuayb Elkhalifa et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Dedicator of cytokinesis 8 (DOCK8) deficiency is a rare autosomal recessive combined immunodeficiency marked by severe atopy, recurrent viral and bacterial infections, high immunoglobulin E, eosinophilia, and lymphopenia...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Distinct EBV-Associated Phenotypes Due to a Novel Homozygous Missense Variant in CD27
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Distinct EBV-Associated Phenotypes Due to a Novel Homozygous Missense Variant in CD27
Rui Yang et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Biallelic deficiencies of CD27 and its ligand CD70 underlie selective susceptibility to Epstein-Barr virus (EBV) infection and its acute and chronic complications, underscoring their nonredundant roles in anti-EBV immuni...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Escherichia coli‐associated follicular cystitis in dogs: Clinical and pathologic characterization
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Escherichia coli‐associated follicular cystitis in dogs: Clinical and pathologic characterization
Sanna J. Viitanen et al · Oxford University Press · 2023 · ISSN 0891-6640
Abstract Background Follicular cystitis is an uncommon inflammatory change in the urinary bladder wall characterized by the formation of tertiary lymphoid structures (TLSs) in the submucosa. Objectives To characterize cl...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Expanded Clinical Spectrum Associated with Heterozygous Variants of RNU4ATAC
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Expanded Clinical Spectrum Associated with Heterozygous Variants of RNU4ATAC
Lila Yang et al · Rockefeller University Press · 2026 · ISSN 3065-8993
IntroductionRNU4ATAC-opathies are characterized by biallelic pathogenic variants and include three recognized phenotypes: autosomal recessive Roifman syndrome, microcephalic osteodysplastic primordial dwarfism (MOPD), an...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Familial Reticular Dysgenesis Due to Adenylate Cyclase 2 (AK2) Deficiency: Insights from a Three-Sibling Case Series
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Familial Reticular Dysgenesis Due to Adenylate Cyclase 2 (AK2) Deficiency: Insights from a Three-Sibling Case Series
Ashna Jain et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Reticular dysgenesis (RD) is a rare, severe form of severe combined immunodeficiency (SCID) caused by biallelic AK2 mutations, leading to profound defects in lymphoid and myeloid maturation. Unlike other SCID phenotypes,...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection
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GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection
Ortiz Wilczyñski, Juan Manuel et al · Public Library of Science · 2020 · ISSN 1553-7366
Multiple sclerosis (MS) is a highly disabling neurodegenerative autoimmune condition in which an unbalanced immune response plays a critical role. Although the mechanisms remain poorly defined, helminth infections are kn...
Idioma eng
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Gene Expression Profiling and Functional Characterization of Macrophages in Response to Circulatory Microparticles Produced during Trypanosoma cruzi Infection and Chagas Disease
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Gene Expression Profiling and Functional Characterization of Macrophages in Response to Circulatory Microparticles Produced during Trypanosoma cruzi Infection and Chagas Disease
Chowdhury, Imran H et al · Karger · 2016 · ISSN 1662-811X
Chronic inflammation and oxidative stress are hallmarks of chagasic cardiomyopathy (CCM). In this study, we determined if microparticles (MPs) generated during Trypanosoma cruzi (Tc) infection carry the host?s signature ...
Idioma eng
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Gentamicin-Induced Acquired Bartter-Like Syndrome: A Case Report and Review of the Literature
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Gentamicin-Induced Acquired Bartter-Like Syndrome: A Case Report and Review of the Literature
Fatih Yılmaz et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
Aminoglycosides are a group of antibiotics commonly used in the treatment of serious gram-negative bacterial infections. We report a case of acquired Bartter-like syndrome (ABLS) observed following gentamicin treatment f...
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Health-Related Quality of Life Reveals Distinct Fatigue and Functional Burden in Inflammatory Common Variable Immunodeficiency
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Health-Related Quality of Life Reveals Distinct Fatigue and Functional Burden in Inflammatory Common Variable Immunodeficiency
Andrew Wong-Pack et al · Rockefeller University Press · 2026 · ISSN 3065-8993
RationaleCommon variable immunodeficiency (CVID) is a chronic, multisystem immune disorder associated with substantial symptom burden beyond infections, particularly among individuals with noninfectious inflammatory comp...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Heterogeneous CD21low B Cell Subsets and Their Functional Impact in Common Variable Immunodeficiency
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Heterogeneous CD21low B Cell Subsets and Their Functional Impact in Common Variable Immunodeficiency
Jitka Smetanová et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Atypical CD21low B lymphocytes are a naturally occurring transient subset that has been increasingly recognized in chronic diseases, such as infections and immune dysregulation, where they may persist for long. Their fat...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Hoigne Syndrome due to Clarithromycin Treatment in a Hemodialysis Patient
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Hoigne Syndrome due to Clarithromycin Treatment in a Hemodialysis Patient
Feyza Nur Sarışık et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
Clarithromycin is an antibiotic that is usually used to treat upper and lower respiratory tract infections. Common side effects are diarrhea, nausea, vomiting, dyspepsia and change of taste in the mouth. Other rare side ...
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Idiopathic Combined Immunodeficiency Associated with Primary Pulmonary Sporotrichosis
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Idiopathic Combined Immunodeficiency Associated with Primary Pulmonary Sporotrichosis
Marija Rowane et al · Rockefeller University Press · 2026 · ISSN 3065-8993
IntroductionSporotrichosis is an uncommon but emerging opportunistic infection in immunocompromised patients. Primary pulmonary sporotrichosis can disseminate and result in significant morbidity and mortality, despite tr...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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IgA Nephropathy and Psoriasis in a Child
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IgA Nephropathy and Psoriasis in a Child
Kibriya FİDAN et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
IgA nephropathy is the most common primary glomerulonephritis worldwide. Painless macroscopic hematuria is frequent in children and often coincides with infections of the upper respiratory tract and/ or digestive system....
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Infection-Associated Cutaneous Vasculitis in Hemodialysis Patients: Two Case Reports
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Infection-Associated Cutaneous Vasculitis in Hemodialysis Patients: Two Case Reports
Didem DEMİRCİOĞLU et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
Patients treated with hemodialysis are predisposed to infections. Catheter-related infections are the most common infections in patients who have a central venous hemodialysis catheter. These infections may lead to bacte...
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Interventions to reduce the prevalence of female genital mutilation/cutting in African countries
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Interventions to reduce the prevalence of female genital mutilation/cutting in African countries
Rigmor C Berg et al · SAGE Publishing · 2012 · ISSN 1891-1803
This Campbell systematic review examines the empirical research on the effectiveness of female genital mutilation/cutting (‘FGM/C’) interventions to reduce the occurrence of FGM/C practices in the 28 African countrie...
LCC TENDOlNvY2lhbCBTY2llbmNlcw~~Idioma eng
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JAK Inhibitors in the Treatment of Psoriasis and Psoriatic Arthritis and the Risk of Skin Malignancies: a Review of Current Evidence
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JAK Inhibitors in the Treatment of Psoriasis and Psoriatic Arthritis and the Risk of Skin Malignancies: a Review of Current Evidence
Marta Kacprzyk et al · Termedia Publishing House · 2025 · ISSN 0033-2526
Psoriasis and psoriatic arthritis are chronic immune-mediated disorders associated with substantially impaired quality of life and comorbidities. Janus kinase (JAK) inhibitors have recently emerged as highly efficient th...
LCC LCC:Medicine; LCC:DermatologyIdioma eng
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Macrorhabdus ornithogaster in ostrich, rhea, canary, zebra finch, free range chicken, turkey, guinea-fowl, columbina pigeon, toucan, chuckar partridge and experimental infection in chicken, japanese quail and mice Macrorhabdus ornithogaster em avestruzes, ema, canário, mandarim, galinha, peru, galinha da Angola, pombo doméstico, rolinha, tucano, perdiz de chuckar e infecção experimental em galinha, codorna e camundongo
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Macrorhabdus ornithogaster in ostrich, rhea, canary, zebra finch, free range chicken, turkey, guinea-fowl, columbina pigeon, toucan, chuckar partridge and experimental infection in chicken, japanese quail and mice Macrorhabdus ornithogaster em avestruzes, ema, canário, mandarim, galinha, peru, galinha da Angola, pombo doméstico, rolinha, tucano, perdiz de chuckar e infecção experimental em galinha, codorna e camundongo
N.R.S. Martins et al · Universidade Federal de Minas Gerais, Escola de Veterinária · 2006 · ISSN 0102-0935
Since 2000, Macrorhabdus ornithogaster "megabacteriosis" has been diagnosed in the avian diseases laboratory in a diversity of avian species and varied spectrum of disease. The disease in some species (chickens, turkeys,...
LCC LCC:Animal cultureIdioma eng
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Main Complications during Pregnancy and Recommendations for Adequate Antenatal Care in Sickle Cell Disease: A Literature Review
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Main Complications during Pregnancy and Recommendations for Adequate Antenatal Care in Sickle Cell Disease: A Literature Review
Camilla Olivares Figueira et al · Federação Brasileira das Sociedades de Ginecologia e Obstetrícia · 2022 · ISSN 0100-7203
Abstract Sickle cell disease (SCD) is the most common monogenic disease worldwide, with a variable prevalence in each continent. A single nucleotide substitution leads to an amino-acid change in the β-globin chain, alte...
LCC TENDOkd5bmVjb2xvZ3kgYW5kIG9ic3RldHJpY3M~Idioma eng
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Molecular factors involved in skin dryness in diabetic patients
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Molecular factors involved in skin dryness in diabetic patients
Joanna Narbutt et al · Termedia Publishing House · 2016 · ISSN 0033-2526
Diabetes is a chronic systemic disease affecting 8.3% of the general population, thus constituting an important clinical and financial problem for healthcare systems throughout the world. Complications of diabetes damage...
LCC LCC:Medicine; LCC:DermatologyIdioma eng
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Mosaic KRAS Mutation Leading to RAS-Associated Autoimmune Leukoproliferative Disorder
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Mosaic KRAS Mutation Leading to RAS-Associated Autoimmune Leukoproliferative Disorder
Batoul Basalom et al · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundRAS-associated autoimmune leukoproliferative disorder (RALD) is a rare immune-dysregulation syndrome caused by pathogenic mutations in RAS–MAPK pathway genes, most commonly KRAS. It is characterized by autoim...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
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N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
Monica Barne et al · Frontiers Media S.A · 2026 · ISSN 2296-858X
BackgroundN-acetylcysteine (NAC) is a key precursor of glutathione (GSH), the lung’s principal antioxidant. First developed as a mucolytic, NAC is now recognized for broader antioxidant, anti-inflammatory, immunomodula...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Offense-defense in bone infection: interferon regulation and the immune evasion of Staphylococcus aureus
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Offense-defense in bone infection: interferon regulation and the immune evasion of Staphylococcus aureus
Jinrong Qian et al · Frontiers Media S.A · 2026 · ISSN 2813-6144
Bone infection is a severe disease caused by microbial invasion of bone tissue, characterized by inflammatory responses, bone destruction, and impaired repair. Its high recurrence rate and refractory nature have posed si...
LCC TENDOk1pY3JvYmlvbG9neQ~~Idioma eng
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Outcomes for Patients with CGD Undergoing HSCT Over the Past 2 Decades: A Single-Center Experience
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Outcomes for Patients with CGD Undergoing HSCT Over the Past 2 Decades: A Single-Center Experience
Erin Morales et al · Rockefeller University Press · 2026 · ISSN 3065-8993
IntroductionChronic granulomatous disease (CGD) is an inborn error of immunity (IEI) secondary to defects in the phagocyte oxidative burst. Patients mainly experience infections; however, many may also manifest inflammat...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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