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ObjectiveTo explore the pro-inflammation resolution and protective effects of reactive oxygen species (ROS)-responsive liposomes modified with a cardiac-targeted peptide and loaded with resolvin D1 (RvD1, C-LP-RvD1) on m...

This study aimed to develop a novel degrader capable of selectively degrading fibroblast growth factor receptor 2 (FGFR2) to overcome the issues of drug resistance and adverse reactions associated with traditional inhibi...

Abstract PBRM1-mutant ccRCC is a subtype of ccRCC with limited treatment options. Currently, there were no effective drugs specifically targeting this mutation. Here, we discovered that PBRM1-mutant ccRCC patients with c...

Palbociclib (PALBO), a CDK 4/6 inhibitor, is currently used in combination with endocrine therapy targeting estrogen receptors to treat advanced luminal breast cancer. However, with time tumors become resistant to these ...

Abstract Background The pathophysiology of heart failure involves maladaptive angiotensin peptides (APs) and enzymes, including angiotensin 2 (AT2) and angiotensin converting enzyme (ACE), as well as recently described a...

Cancer therapy and food preservation both face significant challenges related to stability, targeted delivery, safety, and efficiency of active compounds. Biopolymer-based nanoparticles, particularly those derived from c...

Aim: The objective of our study was to formulate a nanoparticulate drug delivery system that provides controlled delivery of ibuprofen directly targeting colon leading to optimized dosage, reduced side effects ultimately...

Abstract Diabetic retinopathy (DR), the most prevalent ocular complication of diabetes, progresses from non-proliferative (NPDR) to sight-threatening proliferative (PDR) stages. Current interventions—including retinal ...

Abstract Background Gastrointestinal stromal tumors (GISTs) are primarily treated with tyrosine kinase inhibitors (TKIs) such as imatinib. However, the development of drug resistance remains a critical clinical challenge...

BackgroundChronic hepatitis B (CHB) caused by the hepatitis B virus (HBV) remains a major global health burden. The immune-active (IA) phase, characterized by positive Hepatitis B surface antigens (HBsAg), elevated alani...

ABSTRACT Background and Aims Although combination antiretroviral therapy has decreased morbidity and mortality in people living with HIV (PLWH), the prevalence of other sexually transmitted and blood‐borne infections (...

Abstract Objective This study aimed to elucidate the molecular mechanisms by which Apigenin (APG) reverses MET-TKI resistance in non-small cell lung cancer (NSCLC). Methods Network pharmacology and molecular docking were...

Chlamydia psittaci is an obligate intracellular pathogen that poses a significant threat to both human and animal health. The current therapeutic strategies are limited by the emergence of potential drug resistance, unde...

Glioblastoma stem cells (GSCs) and residual tumor cells - which resist conventional therapies, drive disease recurrence, and contribute to the formation of an immunosuppressive tumor-immune microenvironment (TIME) - repr...

Jie Wei,1,* Guan Ye Nai,2,3,* GuoWu Lin,4,* Yu Mei Huang,1 Wei Jie Zhou,4 Rong rong Liu1 1Departments of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ...

Osteoporosis is a very common disease nowadays, and it is mostly seen in postmenopausal women. In postmenopausal women, with the decrease of estrogen, directly or indirectly, it makes the decrease of bone mineral density...

Heart failure (HF) remains a leading cause of morbidity and mortality worldwide, with persistent sterile inflammation emerging as a critical driver of maladaptive cardiac remodeling beyond hemodynamic stress alone. Recen...

Mitochondrial dysfunction is a convergent hallmark of biological aging and a mechanistically attractive target for gerotherapeutic development. Yet translation of mitochondria-focused interventions has been limited by pa...

Abstract Fungal inositol phosphorylceramide (IPC) synthase is an essential enzyme complex that catalyzes a critical step in sphingolipid biosynthesis. It is the molecular target of potent antifungal aureobasidin A (AbA)....

BackgroundAcquired resistance to cisplatin-based chemotherapy is common in patients with gastric cancer (GC) and significantly limits treatment efficacy. The aim of this study was to investigate molecular features associ...

Abstract Background Cardiac fibrosis is a pivotal pathological process driving adverse cardiac remodeling and a defining feature of end-stage heart disease. Nicotine, a principal constituent of tobacco products, is now r...

Abstract Background Parents who experience adverse social risk factors of health (SRFOH) are at risk for child welfare involvement, and those with opioid and/or methamphetamine use (O/MU) and mental health (MH) disorders...

Abstract Scavenging excess reactive oxygen species (ROS) and positively improving intestinal dysbiosis is a promising therapeutic strategy for alleviating inflammatory bowel disease (IBD). However, conventional clinical ...

Abstract Inflammatory diseases remain a major clinical challenge due to their complex pathologies and the limitations of current anti-inflammatory therapies. Conventional treatments, such as non-steroidal anti-inflammato...