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ObjectiveTo analyze the etiological characteristics and homology of Vibrio parahaemolyticus strains isolated from two foodborne outbreaks in July 2024 in a county of Ningbo City.MethodsWhole genome sequencing was perform...

Rotavirus A (RVA) possesses a genome of 11 double-stranded (ds) RNA segments, and each segment encodes one protein, with the exception of segment 11. NSP4 is a non-structural multifunctional protein encoded by segment 10...

The rapid expansion of whole-genome sequencing (WGS) has highlighted the important contribution of noncoding variants to human disease, yet their pathogenic mechanisms remain difficult to resolve. Traditional statistical...

Abstract Anaplasma marginale is a vector-borne pathogen that causes a disease known as anaplasmosis. No sequenced genomes of Brazilian strains are yet available. The aim of this work was to compare whole genomes of Brazi...

Abstract Studying microbial biodiversity offers enormous potential for improving the valorisation of plant biomass, particularly in conversion processes. Microorganisms, such as bacteria, fungi, yeasts and algae, play an...

ABSTRACT Background A 7‐month‐old female spayed English Springer Spaniel (ESS) was evaluated for spontaneous hemoperitoneum. Hyperfibrinolysis was identified on thromboelastography. Hypothesis/Objectives To identify ...

Identification of specific genetic markers that determine interbreed differences and “selection signatures” in commercial pig breeds will allow for the development of more effective strategies for targeted breeding a...

Infections caused by Carbapenem-resistant Acinetobacter baumannii (CRAB) isolates, such as hospital-acquired pneumonia (HAP), bacteremia, and skin and soft tissue infections, among others, are particularly challenging to...

Abstract Background Telomere length (TL), a biomarker of biological aging, but its association with Alzheimer’s disease (AD) remains unclear. Methods We estimated TL in whole-genome sequencing data from 35,014 Alzheime...

Abstract Background Comparative genomics and plastome phylogenomics have advanced significantly in recent years, highlighting the diversity, possible admixture, and non-neutral evolution of the predominantly considered n...

BackgroundDiffuse large B-cell lymphoma (DLBCL), the most common non-Hodgkin lymphoma, exhibits genetic heterogeneity and variable treatment responses. Discovering new therapeutic targets is critical to improve outcomes....

Abstract State-supported research funding agencies are critical to the scientific enterprise. However, it remains unclear how funding agencies cooperate with academic communities to realize common scientific goals. Here,...

Background Genetic recombination maps provide important frameworks for comparative genomics, identifying gene functions, assembling genome sequences and for breeding. The molecular recombination map currently available ...

Abstract Background Representatives of the phylum Methanobacteriota occur in various anoxic environments, but only members of the genera Methanosphaera and Methanobrevibacter exclusively colonize the digestive tract of a...

Objectives: Isolation of colistin- and carbapenem-resistant Klebsiella pneumoniae (CCR-Kp) is increasing in hospital settings worldwide, which is related to increased morbidity, mortality and healthcare costs. The aim of...

Abstract Background Porcine circovirus type 2 (PCV2) and porcine circovirus type 3 (PCV3) have emerged as significant pathogens jeopardizing the swine industry in China in recent years, and caused substantial economic lo...

Satellite DNA (satDNA) is a major component of the heterochromatic regions of eukaryote genomes and usually shows a high evolutionary dynamic, even among closely related species. Section Arachis (genus Arachis) is compos...

A single-stranded DNA (ssDNA) virus was detected in Yerba mate samples showing chlorotic linear patterns, chlorotic rings and vein yellowing. The full-genome sequences of six different isolates of this ssDNA circular vir...

The current study uses machine learning and explainable AI to predict Bedaquiline (BDQ) resistance in Mycobacterium tuberculosis clinical isolates and also predicts 15 new BDQ-resistant genes from whole-genome sequencing...

Abstract Background Aberrant three-dimensional genome organization is a hallmark of cancer. However, the underlying regulatory mechanisms remain elusive. Results Here, we identify β-catenin associated loop hubs in color...

The diagnosis of bovine herpesvirus 5 (BoHV-5) encephalitis is confirmed after death by laboratory methods applied to brain fragments. Alternative methods to confirm ante-mortem diagnosis are important because the diseas...

Although DNA methylation is the best characterized epigenetic mark, the mechanism by which it is targeted to specific regions in the genome remains unclear. Recent studies have revealed that local DNA methylation profile...

Tesis de Licenciatura La fiebre chikungunya es una enfermedad causada por el virus Chikungunya (CHIKV) que genera síntomas inflamatorios y debilitantes (artralgia, artritis y mialgia). Esta enfermedad es transmitida por...