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Abstract Background Microglial activation is increasingly recognized as a critical contributor to both the initiation and chronification of migraine. Recent advances have highlighted the importance of receptor-mediated s...

OBJECTIVE: Clinical studies have demonstrated that tubulointerstitial rather than glomerular pathology correlates with the degree and progression of renal impairment. Urinary n-acetyl-betaD-glucosaminidase (NAG) is a bio...

Abstract Obesity, as defined by the World Health Organization (WHO), is excessive fat accumulation that can pose health risks and is a disorder of the energy homeostasis system. In typical westernized diets, ω-6 polyuns...

Aging constitutes a universal, multi-factorial, progressive and irreversible process. Although the aging process may vary among different tissues, it is usually associated to a chronic inflammatory condition. Relevant to...

Chlamydia trachomatis urogenital infections are the leading cause of sexually transmitted bacterial infections. Although the prevalence of chlamydial infection is similar in men and women, current research is mainly focu...

We evaluated whether the lack of TNF-α signaling increases mucosal levels of annexin A1 (AnxA1); the hypothesis stems from previous findings showing that TNF-α neutralization in Crohn´s disease patients up-regulates s...

This study demonstrates up-regulation of alveolar macrophages expressing genes important for inflammation and lipid metabolism in people with cystic fibrosis, identifying potential therapeutic targets. Cystic fibrosis (C...

Abstract Background Blood eosinophil count is an accepted biomarker for type 2 inflammation in COPD. However, the majority of COPD patients are characterized by non-type 2 inflammation. We aimed to test readily obtainabl...

ObjectiveTo explore the pro-inflammation resolution and protective effects of reactive oxygen species (ROS)-responsive liposomes modified with a cardiac-targeted peptide and loaded with resolvin D1 (RvD1, C-LP-RvD1) on m...

Abstract Background Prestorage leukoreduction of red blood cell (RBC) bags prevents accumulation of pro‐inflammatory mediators and experimentally attenuates post‐transfusion inflammation in healthy dogs. However, the...

Patients with Type 2 Diabetes mellitus (T2DM) were more prone to suffer from periodontitis due to unique alteration in host immune response. Application of curcumin oral gel as adjunctive therapy was expected to improve ...

Introduction and aims: Increasing evidence suggests that marginal zone B and B1 cell-specific protein (MZB1) plays crucial roles in inflammatory responses, endoplasmic reticulum (ER) stress, and cell survival, but its fu...

BackgroundMast cells are abundant throughout the lung, positioned near the airway epithelium, vasculature, and interstitium where they function as frontline sentinels to inhaled environmental and chemical stimuli. Throug...

Increasing observational and experimental trial data have shown that mental stress can lead to an increase in adverse clinical cardiovascular events. Mental stress affects the heart by inducing ischaemia and precipitatin...

Chronic inflammation is a hallmark of many diseases, including persistent viral infections. In human immunodeficiency virus (HIV) infection, sustained immune activation contributes to end-organ damage and non-AIDS comorb...

Abstract Background Air pollution particles exacerbate allergic asthma and can enhance inflammatory responses to allergen exposure, but the cellular mechanisms involved remain incompletely defined. We examined how diesel...

BackgroundComplex inflammatory phenotypes in children can pose significant diagnostic challenges, particularly when clinical, histopathologic, and immunologic findings do not conform to established diagnoses. We present ...

BackgroundX-linked inhibitor of apoptosis protein (XIAP) deficiency is a rare genetic disorder caused by pathogenic variants in the XIAP gene. It disrupts TNF-receptor signaling and NLRP3 inflammasome function, leading t...

ABSTRACT Aims/Introduction Obesity is often accompanied by skeletal muscle atrophy, which aggravates insulin resistance and metabolic dysfunction. Chronic inflammation is implicated in this process, but the molecular med...

Natural products play a significant role in human health in relation to the prevention and treatment of inflammation conditions. Although not fully understood, several action mechanisms are proposed to explain in vivo in...

Abstract The multifaceted pathogenesis and multi-cellular involvement of diabetic nephropathy (DN) stand in stark contrast to the inadequacy of conventional single-target therapeutic strategies. This disparity underscore...

Abstract Objectives To evaluate the prevalence, associated factors, and prognostic performance of NIH activity index–defined interstitial inflammation (NIH-TII) and interstitial fibrosis and tubular atrophy (IFTA) in l...

BackgroundMetabolic syndrome (MetS) affects approximately 1.54 billion adults worldwide and is characterized by central obesity, insulin resistance, hypertension, and dyslipidemia. Chronic low-grade inflammation is cen...

AIM: The hepatitis B infection is a subject that still keeps its significance for hemodialysis staff members and hemodialysis patients at present. In this study, our aim was to evaluate whether the infections occurring d...