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Arsenic (As) is a toxic metalloid, and its accumulation in macroalgae has raised concerns for aquatic ecosystem health and human food safety given the increasing consumption of macroalgae. While previous studies have pre...

Glioblastoma is the most common and aggressive primary brain tumor in adults that fails to meet survival endpoint criteria in current immunotherapy Phase III clinical trials. As a small subset of immunotherapy-responsive...

IntroductionC5orf46 is a recently discovered tumor-progression-related gene whose function in most cancers is still unknown, especially its potential role in regulating the tumor microenvironment (TME). The aim of the st...

S-adenosylhomocysteine (SAH) hydrolase deficiency is a rare autosomal recessive disorder caused by pathogenic variants of the gene AHCY. Loss of SAH hydrolase causes SAH accumulation and impairs the methionine/S-adenosyl...

Abstract Background Lung cancer remains the leading cause of cancer-related mortality worldwide. This study aimed to develop prognostic prediction models for lung squamous cell carcinoma (LUSC) through multi-omics integr...

O processo de contaminação por mercúrio em ecossistemas aquáticos é discutido, levando-se em consideração as características biogeoquímicas atuantes nesses sistemas que resultam em uma maior mobilização e biod...

BackgroundOral submucosal fibrosis (OSF) is a chronic and progressive disorder, caused by chewing areca nuts, affecting the oral cavity and oropharynx. OSF is characterized by severe symptoms like severe burning sensatio...

Abstract Therapeutic resistance remains a major cause of treatment failure and disease recurrence across cancer types, considerably limiting the long-term efficacy of chemotherapies, targeted therapies, and immunotherapi...

Acute kidney injury (AKI) is a risk factor for chronic kidney disease and death. Chronic kidney disease (CKD) has become a serious public health problem because of its associated morbidity, mortality, and health care cos...

Abstract Folate (FA), essential for DNA synthesis, repair and methylation, is predominantly stored and metabolized in the liver. Dysregulation of folate intake and metabolism is strongly implicated in the pathogenesis of...

Abstract A growing body of evidence supports the role of nutrient sensing and metabolism pathways in regulating ageing rate and healthspan, but the diversity of human lifestyles challenges our ability to identify the mec...

Abstract Objective To explore new diagnostic markers and therapeutic targets associated with the histological types of thymoma. Methods The TCGA and GEO was used to gather genomic and clinical data from thymoma patients....

Objective: Periodontitis is a chronic inflammatory disease that severely affects oral and general health. N7-methylguanosine (m7G) methylation plays critical roles in regulating gene expression and cellular functions. Me...

Objective: Diabetic retinopathy (DR) is a major microvascular complication of diabetes. This study aimed to elucidate the protective effects of curcumin, a bioactive dietary compound derived from turmeric, and its underl...

Jiawei Zhao,1,* Yuting Gou,1,* Yiyang Wang,1,* Yongxiang Li,1 Haotian Ma,1 Yiting Xing,2 Haohao Peng,2 Chenming Guo1,3 1Department of Breast Surgery, Center of Digestive and Vascular, The First Af...

Abstract Background The IDH-mutant low-grade glioma (LGG) involving corpus callosum (ccLGG) is a rare type of LGG which has a poorer prognosis. To evaluate the efficacy of multimodal techniques (comprising neuronavigatio...

Abstract Ornithine lipids (OLs) are phosphorus-free membrane lipids present in many bacteria, but absent from eukaryotes and archaea. Three pathways for OL synthesis have been reported to date. Conditions that induce OL ...

Post-translational modifications (PTMs) play pivotal roles in ovarian cancer pathogenesis, with poly(ADP-ribosyl)ation (PARylation) serving as a key regulator of DNA repair, immune evasion, and therapeutic resistance. Be...

Abstract Little is known about the regulation and function of phase separation in craniofacial developmental disorders. MSX1 mutations are associated with human cleft palate, the most common craniofacial birth defect. He...

Abstract Background  The genomic and epigenetic landscape of the gasdermin family across cancers, and its clinical relevance, remain incompletely defined.  Methods Multi-omics features of gasdermins across 33 cancer ty...

Abstract Background Aberrant three-dimensional genome organization is a hallmark of cancer. However, the underlying regulatory mechanisms remain elusive. Results Here, we identify β-catenin associated loop hubs in color...

Post-transplant lymphoproliferative disorders (PTLD) represent a heterogeneous group of complications with rising complexity, particularly as EBV-negative forms are increasingly recognized in adult recipients. While earl...

Natural antisense transcripts (NATs) from eukaryotic genes, known as long non-coding RNAs (lncRNAs), are long transcripts that do not encode proteins. NATs play diverse functional roles in regulating the transcription, s...

Phylloquinone is a redox active naphthoquinone involved in electron transport in plants. The function of this reduced form remains unclear due to its instability, which has precluded detection. Herein, a simple method th...