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Airborne particulate matter 10 (PM10) induces lung inflammation. However, interventions remain limited. We evaluated the protective effects of Chrysanthemum zawadskii var. latilobum (CZL) against PM10-induced lung injury...

Aging associated with cellular senescence was responsible for the degradation of collagen and elastin by activation of matrix metalloproteinases (MMPs) that produced wrinkles. Black garlic is known to have an anti-aging ...

Abstract Silver nanoparticles show promise anticancer agents, yet their clinical translation is hindered by poor bioavailability and nonspecific toxicity. In this study, we developed an apigenin-functionalized silica-coa...

Colorectal cancer (CRC) ranks as the third most diagnosed cancer and the second leading cause of cancer-related mortality globally. Hexokinase II, a key rate-limiting enzyme in tumor glycolysis, is an important therapeut...

IntroductionIntestinal ischemia-reperfusion (I/R) injury, a common and severe clinical condition with high morbidity and mortality, burdens healthcare systems. Our previous investigations established that a nano-delivery...

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy in which immune dysregulation and metabolic remodeling are common features. Laminin subunit alpha 3 (LAMA3), a component of lamini...

BackgroundCerebral ischemic injury includes ischemic stroke in adults and hypoxic-ischemic encephalopathy (HIE) in newborns. Delphinidin-3-O-glucoside (Dp3G) is a bioactive anthocyanin abundant in vibrantly colored plant...

IntroductionHormone-associated cancers use steroid metabolism to grow and avoid the immune system, while traditional treatments have to deal with drug resistance and systemic toxicity.MethodsThis study is mainly divided ...

The prevalence rate of mortality in colorectal cancer is comparatively elevated. A standard or effective treatment has not been developed to resolve this issue. Utilizing Muntingia calabura, which is known to contain rut...

Phthalate plasticizers, especially diethyl phthalate (DEP), are linked to metabolic disorders, while their precise role and mechanism in diabetic nephropathy (DN) pathogenesis remain unclear. Here, we integrated transcri...

Abstract Fatty acid ethanolamides (FAEs) are bioactive lipids with amphiphilic properties and potential as prodrugs. In this study, a homologous series of FAEs (C8:0–C18:0) was evaluated for solubility, hydrophobicity,...

Abstract Background Olfactory detection of host odors is fundamental to mosquito host-seeking behavior. Although the olfactory pathways of model species such as Anopheles gambiae have been well characterized, the molecul...

BackgroundSarcopenia, an age-correlated decline in skeletal muscle mass and function, has been increasingly linked to ferroptosis, which is an iron-dependent form of regulated cell death driven by lipid peroxidation. Nev...

Background The long-term biological effects of low-level exposure to artificial sweeteners remain debated. We integrated computational toxicology and Mendelian randomization (MR) to explore potential biological responses...

Breast cancer is one of the leading causes of mortality among women worldwide and is frequently associated with the overexpression of Estrogen Receptor alpha (ERalpha). This study aimed to evaluate the potential of imida...

Abstract The growing prevalence of multidrug-resistant Gram-negative pathogens highlights the urgent need for therapeutic strategies that complement traditional antibiotics by targeting essential virulence pathways. Glyc...

Abstract/Resumen: Trypanosoma cruzi and Plasmodium falciparum are the etiologic agents of Chagas disease and Malaria, respectively. Cysteine proteases play key roles in the pathogenesis and survival of these parasites, s...

Tire and Road Wear Particles (TRWP) are pervasive environmental contaminants, yet the molecular mechanisms linking their toxic derivative, 6PPD-quinone (6PPD-Q), to bladder cancer (BLCA) progression remain obscure. This ...

IntroductionAvian pathogenic Escherichia coli (APEC) infection poses a serious threat to the poultry industry and is increasingly difficult to control because of antimicrobial resistance.MethodsThis study combined microb...

Abstract Objective This study aimed to elucidate the molecular mechanisms by which Apigenin (APG) reverses MET-TKI resistance in non-small cell lung cancer (NSCLC). Methods Network pharmacology and molecular docking were...

The current study provides a comprehensive look of the adsorption process of Candida rugosa lipase (CRL) on Ca2Fe2O5 iron oxide nanoparticles (NPs). Protein-support interactions were identified across a broad range of pH...

Alcoholic gastric ulcer is a clinically prevalent gastrointestinal disorder whose pathogenesis is closely associated with both the direct mucosal damage induced by ethanol and the subsequent inflammatory response. Isoliq...

Jie Wei,1,* Guan Ye Nai,2,3,* GuoWu Lin,4,* Yu Mei Huang,1 Wei Jie Zhou,4 Rong rong Liu1 1Departments of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ...

Abstract Objective Myelodysplastic syndromes (MDS) are associated with a high risk of progression to leukemia, highlighting the critical need to explore novel therapeutic agents. Based on network pharmacology predicti...