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Abstract Perinatal failure in the growth hormone (GH)-insulin-like growth factor-1 (IGF-1) axis causes impaired body growth and central and autonomous neurodevelopmental disorders. However, whether a primary neurodevelop...

ABSTRACT Cerebral palsy (CP), mainly resulting from preterm white matter injury (PWMI), remains a leading neurodevelopmental disorder. While oligodendrocyte precursor cell (OPC) differentiation failure is central to PWMI...

Brain-Derived Neurotrophic Factor (BDNF) is the most abundant neurotrophin in the central nervous system with essential roles in neurodevelopment and maintenance of healthy brain function. Accordingly, BDNF has been sugg...

Background Psychiatric comorbidities are common in patients with epilepsy. Reasons for the co-occurrence of psychiatric conditions and epilepsy remain poorly understood.Aim We aimed to triangulate the relationship betwee...

Abstract The global rise in mental health conditions has prompted interest in interventions that act beyond conventional psychopharmacology. Psychobiotics, broadly understood as live microorganisms or microbe‐derived p...

Autism spectrum disorder (ASD) is a neurodevelopmental disorder, which seriously affects children’s normal life. Screening potential autistic children before professional diagnose is helpful to early detection and earl...

ABSTRACT Background and Aim Handedness is a manifestation of cerebral lateralization that has been implicated in various neurological and neurodevelopmental conditions. Despite extensive research, the relationship betwee...

This article uncovers the ability of the CDKL5 kinase to form intracellular condensates through liquid–liquid phase separation primarily mediated by a serine-rich low-complexity region. The loss of this region caused b...

Xiaolu Deng,1,2 Shimeng Chen,1,2 Fei Yin,1,2 Fang He,1,2 Ciliu Zhang,1,2 Lifen Yang,1,2 Leilei Mao,1,2 Li Yang,1,2 Yang Han,1,2 Jing Peng1,2 1Department of Pediatrics, Xiangya Hospital, Central South University, Changsha...

Inborn errors of immunity (IEI) can manifest with neurological disorders, indicating genetic overlap between immune and nervous system diseases. However, neurological disorder genes are rarely screened systematically for...

Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by heterogeneity in its genetic, epigenetic, and environmental etiologies, posing significant challenges for therapeutic development...

Abstract Background Timely diagnosis and therapeutic management of rare diseases (RDs) are greatly hampered by limited clinical information and a lack of reliable epidemiological data. RDs constitute a heterogeneous grou...