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Benzocaine (BZC) is an ester-type local anesthetic used mainly in topical, dermal and mucosal formulations. The present work consists of the development and validation of analytical methodology for evaluation of benzocai...

The solubility behaviour of drugs remains one of the most challenging aspects in formulation development. Solid dispersions (SD) and inclusion complexes (IC) are two of the most promising strategies to improve the oral...

The main objective of this work was to obtain biodegradable nancomposites from polycaprolactone and bentonite with optimized mechanical properties by the chemical modification of the clay (cation exchange reactions). Fir...

Fil: Britos, Claudia Noelia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina. Fil: Britos, Claudia Noelia. Consejo Nacional d...

Fil: Carbajal, María Laura. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Materiales Biotecnológicos; Argentina. Los materiales funcionales avanzados son altamente demandados p...

Hydrochlorothiazide (HCTZ) is a thiazide diuretic used in pediatric patients despite the lack of a liquid form commercially available. Pediatric suspensions containing 0.6% of CMC-Na (F1) or 0.6% of HPMC (F2) were develo...

The project was aimed to develop floating microcapsules (FMs) using combination of a hydrophobic (ethyl cellulose, EC) and hydrophilic polymer (hydroxy propyl methyl cellulose, HPMC), and to evaluate them. An easy and no...

Fil: Soto Espinoza, Silvia L. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladi...

Fil: Ondarse Álvarez, Danielys. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Fil: Ondarse Álvarez, Danielys. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina...

Neste estudo, comprimidos matriciais de captopril foram desenvolvidos utilizando-se hidroxipropilmetilcelulose (HPMC) e quitosana (QTS) em diferentes proporções (50:50, 60:40, 40:60, 20:80), por compressão direta. Os ...

A biphasic gastroretentive drug delivery system of acyclovir consisted of loading dose tablet and floating multiple matrix tablets was prepared by direct compression process. The delivery system was designed by hydroxy...

Diclofenaco foi associado a nanocápsulas e a nanoesferas, preparadas através do método de nanoprecipitação, utilizando poli(e -caprolactona) (PCL) ou Eudragit S90® (EUD) como polímeros. As suspensões obtidas fora...

Chitosan is increasingly used as an alternative to synthetic polymers due to its water solubility, biodegradability, and biological activity. In this work, chitosan samples from three suppliers were evaluated and charact...

O principal objetivo deste trabalho foi desenvolver sistemas matriciais obtidos da mistura pectina/ HPMC e lactose/HPMC como polímeros capazes de modular a liberação colônica de quercetina. Os comprimidos matriciai...

O captopril foi previamente revestido em leito fluidizado com os polímeros etilcelulose, metilcelulose e polivinilpirrolidona. A partir dos grânulos formados foram desenvolvidos comprimidos de liberação prolongada e ...

The objective of the present research was to develop acyclovir ophthalmic emulgels using different polymers such as Pluronic F 127 (PF 127), Gelrite, Carbopol 934P, hydroxypropylmethylcellulose (HPMC K100M) and sodium ca...

The present investigation concerns the development of mucoadhesive tablets of captopril which were designed to prolong the gastric residence time after oral administration. Matrix tablets of captopril were formulated u...

The present study evaluated novel polymer mixtures prepared by spray drying of an aqueous dispersion of moth bean starch with Carbopol 934P and HPMC K4M for to be used as platform for peroral mucoadhesive drug delivery...

The purpose of this paper was to produce controlled-release matrices with 120 mg of propranolol hydrochloride (PHCl) employing hydroxypropyl methylcellulose (HPMC, Methocel® K100) as the gel forming barrier. Although th...

The aim of the present study is to prepare bilayered floating tablets of diltiazem with different ratios of polymers like HPMC K4M, carbopol 934 P, sodium alginate, Plantago ovata seed husk (psyllium) and to carry out ev...

The present study was undertaken to evaluate the effect of glyceryl monostearate (GMS) and stearic acid (SA) on the release profile of gliclazide from the matrix. Matrix tablets for the controlled delivery of gliclazide ...

The aim of the present investigation is to improve the dissolution of poorly water soluble drug valsartan by preparing solid dispersions and also to evaluate the effect of different inert carriers on flow properties of s...

Nimesulide was formulated as novel dual coated microparticles using chitosan (CTN) and ethyl cellulose (EC) as encapsulating materials for its improved delivery to the intestine and to prevent gastric irritation and incr...

Os polihidroxialcanoatos são poliésteres de hidroxiácidos sintetizados por inúmeras bactérias, como compostos que servem como fonte de carbono intracelular e energia, sendo acumulados na forma de grânulos no cito...