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Abstract Bone defects present significant challenges in clinical practice due to the limitations of traditional treatments. Compared to traditional cell therapies, exosome-based therapies have emerged as a promising alte...

GATA transcription factors and their Friend of Gata (FOG) cofactors control the development of diverse tissues. GATA4 and GATA6 are essential for the expansion of the embryonic liver bud, but their expression patterns an...

End-stage renal disease remains a major global health burden, and novel regenerative strategies are urgently needed. Embryonic metanephros transplantation has emerged as a promising approach, but the optimal site for eng...

Soil is a living, finite resource that shapes chemical fate, microbial ecology, nutrient supply, and climate regulation, yet environmental science and policy often treat it as an inert substrate. Approximately one-third ...

ABSTRACT Bone injuries, particularly those associated with an aging global population, pose a persistent and complex clinical challenge. Current gold‐standard treatments such as autografts, allografts, and metal implan...

Pluripotent stem cells (PSCs) are capable of self-renewing and producing all cell types derived from the three germ layers in response to developmental cues, constituting an important promise for regenerative medicine. P...

ABSTRACT There is a growing interest in the study of unspecialized mesenchymal stem cells, for there are still some discussions about their in vitro behavior. Regenerative medicine is a science undergoing improvement whi...

Abstract Background Developing regenerative therapies to restore kidney function in patients with progressive renal disease represents a major challenge for modern molecular nephrology. Kidney organoids, three-dimensiona...

ABSTRACT In this study, neem leaves were successively extracted with petroleum ether, 95% ethanol and water and the insecticidal activities of these extracts against Oxya chinensis larvae were measured. The results showe...

Networks are essential to ensuring the balance of metropolitan structures, especially in medium-to-low density areas, where their vitality depends on the integration of functions, services, and accessibility. In contrast...

Abstract Intervertebral disc (IVD) degenerative disease is a prevalent and debilitating spinal disease. Current treatments only focus on symptomatic relief but fail to halt disease progression or restore the native biome...

Lipopolysaccharide (LPS) triggers signal transduction in dental pulp cells (DPCs), leading to various biological events. The present study described the biological response of DPCs to LPS, aiming to provide a deeper unde...

Introduction and aims: Increasing evidence suggests that marginal zone B and B1 cell-specific protein (MZB1) plays crucial roles in inflammatory responses, endoplasmic reticulum (ER) stress, and cell survival, but its fu...

Background: Spinal cord injury (SCI) has emerged as a major challenge to global public health due to its low recovery rate and high disability rate, making the development of novel therapeutic approaches imperative. Mese...

There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine in the brain as they have shown neurogenic and immunomodulatory activities. We assessed the effect of i...

Background: Carpal tunnel syndrome (CTS) is the most prevalent entrapment neuropathy and represents a major functional and socioeconomic burden. Although surgical decompression remains the gold standard for advanced dise...

ABSTRACT Monoclonal gammopathy (MG) is rare in dogs and multiple myeloma (MM) is its main cause. This study reports the case of a female dog which presented MG associated with a MM and consequent blood hyperviscosity syn...

The study investigated the regenerative potential of a water-salt extract of the medicinal leech Hirudo verbana in excisional skin wounds of rats, focusing on its influence on hair follicle restoration. Sixty male rats w...

Abstract Background Current bone tissue engineering scaffolds face challenges such as inadequate mechanical support, limited biocompatibility, and suboptimal osteogenesis for treating critical-sized bone defects. This st...

ABSTRACT Peripheral nerve regeneration continues to pose a significant clinical challenge, primarily attributable to the inherently limited regenerative capacity of axons and the intricate inflammatory microenvironment t...

Abstract Angiogenesis underpins regenerative success and refined autologous platelet concentrates (APCs) are therefore under continual optimization. This study compared optimized thermally-induced albumin hydrogel cross-...

Two anatomically and functionally distinct populations of periodontium-derived fibroblasts can be identified: gingiva fibroblasts (GFs), which originate from the soft connective tissue of the gingiva and support epitheli...

Latest Development of Guided Tissue Regeneration and Guided Bone Regeneration Membrane as Regenerative Therapy on Periodontal Tissue. Periodontitis is a patological state which influences the integrity of periodontal s...

Rosewood (Dalbergia latifolia Roxb.) is a tree species with high economic value. The latest data on the global rosewood population was reported in 2020 to be in a vulnerable state of extinction, due to exploitation and r...