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Continuous evolving humanoid for advanced cellular models
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Continuous evolving humanoid for advanced cellular models
Daisuke Shimojo et al · Elsevier · 2026 · ISSN 2472-6303
Drug discovery research faces significant challenges, with around 90 % of candidate drugs failing in clinical trials. Traditional animal models do not always accurately reflect human physiology and pathology, leading to ...
LCC TENDOkJpb3RlY2hub2xvZ3k~; TENDOk1lZGljYWwgdGVjaG5vbG9neQ~~Idioma eng
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Engineering a 3D matrix from porcine plasma for enhanced cell proliferation and differentiation
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Engineering a 3D matrix from porcine plasma for enhanced cell proliferation and differentiation
Yangyang Ma et al · Frontiers Media S.A · 2026 · ISSN 2297-1769
IntroductionThe limited availability of suitable scaffolds for three-dimensional (3D) cell culture has driven the development of new biomaterials. In this study, we developed a porcine fibrin matrix gel (PFMG) derived en...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Exosome-loaded hydrogels for bone regeneration: a cell-free therapeutic strategy
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Exosome-loaded hydrogels for bone regeneration: a cell-free therapeutic strategy
Shengyu Jin et al · BMC · 2026 · ISSN 1754-1611
Abstract Bone defects present significant challenges in clinical practice due to the limitations of traditional treatments. Compared to traditional cell therapies, exosome-based therapies have emerged as a promising alte...
LCC LCC:Biology (General)Idioma eng
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From bench to bedside: advances in cell therapy for tuberculosis treatment
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From bench to bedside: advances in cell therapy for tuberculosis treatment
Li Chunxiao et al · BMC · 2026 · ISSN 1757-6512
Abstract Tuberculosis (TB) remains a major global public health challenge, with drug-resistant tuberculosis (DR-TB) presenting a serious threat to TB management. Conventional treatment faces challenges such as significan...
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Injectable alginate hydrogels improve the effects of subretinal hiPSC-derived RPE cell therapy on retinal degeneration in rats
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Injectable alginate hydrogels improve the effects of subretinal hiPSC-derived RPE cell therapy on retinal degeneration in rats
Zeyu Tian et al · Elsevier · 2026 · ISSN 2590-0064
Subretinal delivery of retinal pigment epithelium (RPE) cells is an important treatment for retinal degeneration patients, and the cell suspension method is the most common approach. Injectable hydrogel-mediated cell eng...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; LCC:Biology (General)Idioma eng
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The Presence of Recipient-Derived Renal Cells in Kidney Allografts
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The Presence of Recipient-Derived Renal Cells in Kidney Allografts
Türkan METE et al · Turkish Society of Nephrology · 2019 · ISSN 2667-4440
OBJECTIVE: Stem cells may be involved in the repair processes of renal tissues during various disorders. We aimed to search the presence of recipient originated cells in renal allograft tissues from patients with various...
LCC LCC:Internal medicine; TENDOlBlZGlhdHJpY3M~Idioma eng
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Are we there yet? The road to faster and more efficient CAR T cell manufacturing
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Are we there yet? The road to faster and more efficient CAR T cell manufacturing
Leonor N. Matos et al · BMC · 2026 · ISSN 1754-1611
Abstract Chimeric antigen receptor (CAR) T cell therapies have achieved clinical success in autologous treatment of hematological malignancies. However, their broader application remains limited. Beyond the biological ch...
LCC LCC:Biology (General)Idioma eng
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Cystinosin regulates Na+/H+ exchanger 3 trafficking and function in kidney proximal tubular cells
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Cystinosin regulates Na+/H+ exchanger 3 trafficking and function in kidney proximal tubular cells
Veenita Khare et al · Springer Nature · 2026 · ISSN 1469-3178
Abstract Cystinosis is a systemic lysosomal storage disease resulting from mutations in the CTNS gene encoding the lysosomal cystine transporter cystinosin, leading to cystine accumulation in all organs. Despite cystinos...
LCC LCC:Biology (General)Idioma eng
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A novel OTUD5 variant disrupts neural progenitor cell homeostasis: mechanistic insights from HEK293T cell-based analyses
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A novel OTUD5 variant disrupts neural progenitor cell homeostasis: mechanistic insights from HEK293T cell-based analyses
Na Xu et al · BMC · 2026 · ISSN 1757-6512
Abstract Background Variants in OTUD5 are associated with neurodevelopmental disorders (NDDs), yet the underlying molecular mechanisms remain unclear. This study aimed to investigate the pathogenicity of a novel OTUD5 va...
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Deciphering immune and cellular reprogramming during the progression from inflammatory bowel disease to colorectal cancer using multi-omics single-cell and spatial transcriptomics
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Deciphering immune and cellular reprogramming during the progression from inflammatory bowel disease to colorectal cancer using multi-omics single-cell and spatial transcriptomics
Seyed Taleb Hosseini et al · BMC · 2026 · ISSN 1479-5876
Abstract Background Inflammatory bowel disease (IBD) represents a group of chronic and relapsing inflammatory disorders of the gastrointestinal tract, primarily encompassing Crohn’s disease (CD) and ulcerative colitis ...
LCC LCC:MedicineIdioma eng
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The Comparison of Commercial Serum-Free Media for Hanwoo Satellite Cell Proliferation and the Role of Fibroblast Growth Factor 2
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The Comparison of Commercial Serum-Free Media for Hanwoo Satellite Cell Proliferation and the Role of Fibroblast Growth Factor 2
In-sun Yu et al · Springer Nature · 2023 · ISSN 2636-0772
Abstract Fetal bovine serum (FBS), which contains various nutrients, comprises 20% of the growth medium for cell-cultivated meat. However, ethical, cost, and scientific issues, necesitates identification of alternatives....
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Animal cultureIdioma eng
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The L-Ascorbic Acid Increases Proliferation and Differentiation of Yanbian Cattle Skeletal Muscle Satellite Cells by Activating the Akt/mTOR/P70S6K Signaling Pathway
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The L-Ascorbic Acid Increases Proliferation and Differentiation of Yanbian Cattle Skeletal Muscle Satellite Cells by Activating the Akt/mTOR/P70S6K Signaling Pathway
Huaina Jin et al · Springer Nature · 2025 · ISSN 2636-0772
Abstract Cell-cultured meat, as a new type of meat food, can effectively mitigate the negative effects of conventional animal husbandry on the environment, health, and animal welfare. Muscle stem cells are the main seed ...
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Animal cultureIdioma eng
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The Role of COQ10B in Tumor Progression and Its Association with Immune Escape in Esophageal Squamous Cell Carcinoma: A Multi-Omics and Functional Analysis
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The Role of COQ10B in Tumor Progression and Its Association with Immune Escape in Esophageal Squamous Cell Carcinoma: A Multi-Omics and Functional Analysis
Cao L et al · Dove Medical Press · 2026 · ISSN 1178-7074
Leiyu Cao,* Xingfang Wei,* Yu Wei, Xiaoli Ma, Yan Gao, Chengcheng Qu, Wen Yi, Kalima Muhetaer, Li Zhang Cadre Healthcare Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinji...
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First-in-human use of recombinant IL-7 to potentiate antigen-specific T cell therapy: a single patient case study
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First-in-human use of recombinant IL-7 to potentiate antigen-specific T cell therapy: a single patient case study
Linghua Wang et al · BMJ Publishing Group · 2026 · ISSN 2051-1426
Clinical trials of adoptive cellular therapy demonstrate that a key characteristic associated with durable responses is in vivo expansion and persistence of transferred T cells. Strategies to develop a less differentiate...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Functional Characterization of a Biallelic ITK D266H Variant Implicated in Infantile Fulminant and Giant Cell Hepatitis
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Functional Characterization of a Biallelic ITK D266H Variant Implicated in Infantile Fulminant and Giant Cell Hepatitis
Areli Flores Camargo et al · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundInterleukin-2–inducible T cell kinase (ITK) deficiency classically presents with EBV-driven lymphoproliferation and lymphoma, but emerging data suggest broader phenotypes of immune dysregulation. The pathogen...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Prospective Clinical Trial of Mycophenolate Mofetil (MMF) Duration De-Escalation in Allogeneic Hematopoietic Cell Transplantation (HCT) for Inborn Errors of Immunity: Is MMF Dispensable After Reduced Intensity Conditioning, Posttransplantation Cyclophosphamide(Ptcy)-Based HCT?
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Prospective Clinical Trial of Mycophenolate Mofetil (MMF) Duration De-Escalation in Allogeneic Hematopoietic Cell Transplantation (HCT) for Inborn Errors of Immunity: Is MMF Dispensable After Reduced Intensity Conditioning, Posttransplantation Cyclophosphamide(Ptcy)-Based HCT?
Dimana Dimitrova et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Hematopoietic cell transplantation (HCT) offers curative potential for inborn errors of immunity (IEI) patients, who often enter HCT with significant comorbidities and disease sequelae, active infections, and/or limited ...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Seasonal Surge of Steroid-Refractory T Cell–Mediated Hepatitis in Phoenix: A Cascade of Cases and Treatment Dilemmas
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Seasonal Surge of Steroid-Refractory T Cell–Mediated Hepatitis in Phoenix: A Cascade of Cases and Treatment Dilemmas
Lance Milovancev et al · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundT cell–mediated hepatitis is an uncommon cause of acute pediatric liver injury. Most patients respond to steroids, but management of refractory disease remains challenging. We describe four patients with non-...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Severe B Cell Lymphocytosis with Autoimmune Cytopenia and Lymphoproliferative Disease in an Infant with a CARD11 Gain-of-Function Mutation
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Severe B Cell Lymphocytosis with Autoimmune Cytopenia and Lymphoproliferative Disease in an Infant with a CARD11 Gain-of-Function Mutation
Batoul Basalom et al · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundB cell Expansion with NF-κB Activation and T cell Anergy (BENTA) disease is a rare inborn error of immunity caused by gain-of-function (GOF) variants in CARD11. It is characterized by early-onset lymphadenopat...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Biological characteristics of intestinal organoids versus in vivo intestinal crypts and mechanisms underlying their differential responses to nobiletin
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Biological characteristics of intestinal organoids versus in vivo intestinal crypts and mechanisms underlying their differential responses to nobiletin
LI Xuan et al · Editorial Office of Journal of Army Medical University · 2026 · ISSN 2097-0927
Abstract Objective Intestinal organoids serve as important tools for drug screening, but the extent to which they recapitulate in vivo tissue microenvironments and drug responses remains inadequately evaluated. This s...
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Effect of chitosan–hydroxyapatite scaffolds seeded with cryopreserved hADMSCs on bone sialoprotein secretion
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Effect of chitosan–hydroxyapatite scaffolds seeded with cryopreserved hADMSCs on bone sialoprotein secretion
Michael Josef Kridanto Kamadjaja et al · faculty of dentistry universitas gadjah mada · 2025 · ISSN 2460-0164
Tooth extraction can lead to alveolar bone resorption, requiring regenerative approaches using biomaterial scaffolds combined with stem cells. Chitosan–hydroxyapatite (CS–HA), a well-established scaffold that mimics ...
LCC TENDOkRlbnRpc3RyeQ~~Idioma eng
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Epidemiological Characteristics and 3-year Overall Survival Outcome of Nasopharyngeal Cancer in Central Java: A Single Institution Retrospective Study
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Epidemiological Characteristics and 3-year Overall Survival Outcome of Nasopharyngeal Cancer in Central Java: A Single Institution Retrospective Study
Rikha Liemiyah et al · Dharmais Cancer Hospital - National Cancer Center · 2024 · ISSN 1978-3744
Background: Metastasis is the most common cause of death in breast cancer and nodal metastasis is one of the most important predictive factors for distance metastasis. One of the intrinsic properties of cancer cells is t...
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High CD90 Expression is A Predictor of Axillary Nodal Metastasis in Breast Carcinoma
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High CD90 Expression is A Predictor of Axillary Nodal Metastasis in Breast Carcinoma
Ni Putu Sriwidyani et al · Dharmais Cancer Hospital - National Cancer Center · 2024 · ISSN 1978-3744
Background: Metastasis is the most common cause of death in breast cancer and nodal metastasis is one of the most important predictive factors for distance metastasis. One of the intrinsic properties of cancer cells is t...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Impact of the CYFIP2 R87C variant in a human neuronal model in vitro
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Impact of the CYFIP2 R87C variant in a human neuronal model in vitro
Isabelle Zaboroski-Silva et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Mutations in the CYFIP2 gene, particularly the R87C variant, are associated with severe epileptic encephalopathy, and present challenges for therapeutic development. This study utilized CRISPR/Cas9-edited human ...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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In vitro evaluation of gamma irradiation versus autoclaving on the morphology and regenerative potential of Allo-demineralized dentin matrix
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In vitro evaluation of gamma irradiation versus autoclaving on the morphology and regenerative potential of Allo-demineralized dentin matrix
Marwa Ahmed Abozed et al · BMC · 2026 · ISSN 1472-6831
Abstract Background Demineralized dentin matrix (DDM) can serve as a novel scaffold for dental tissue regeneration. This study aimed to assess the impact of two distinct sterilizing methods on morphology of Allo-DDM as w...
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