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IntroductionThe ERCC2 gene, located on chromosome 19, is essential for transcription and DNA repair via its protein product, XPD. Mutations in ERCC2 cause disorders such as trichothiodystrophy-1, xeroderma pigmentosum, C...

The general aim of this study, which was conducted for the first time in Iran, was to evaluate the seroprevalence and geographical distribution of Ehrlichia canis in a dog population in Iran, followed by molecular confir...

Abstract Piroplasm species were analyzed by molecular tools in total 31 blood samples from positive dogs, previously checked by stained slides, stored until DNA extraction between 2016 to 2018 in the laboratory Clinical ...

ABSTRACT Fish are considered one of the important sources of protein which are invaded by different parasites. This study aimed to shed light on monogenean parasites that infect fish within the family Sparidae in Saudi A...

Abstract The well-established tumor suppressor, Breast Cancer Susceptibility Gene 1 (BRCA1), has been implicated in lipid metabolism and in paradoxically promoting hepatocellular carcinoma (HCC); yet its mechanistic rol...

The IKAROS family of zinc finger transcription factors (IKZF1–4) plays a central role in lymphocyte development and immune regulation. Pathogenic IKZF1 variants produce a wide phenotypic spectrum related to whether the...

ABSTRACT Polymorphisms in the BMP-15 gene related to Galway (FecXG) and Inverdale (FecXI) and in the BMPR-1B gene known as Booroola (FecB) mutations were investigated using the Polymerase Chain Reaction - Restriction Fra...

Abstract Background Hyperglycemia, a hallmark of diabetes mellitus, is a metabolic condition that highly affects the nervous system. While evidence from epidemiological and animal studies links diabetes to dopaminergic d...

ABSTRACT A detailed analysis of how muscle fiber nuclei (myonuclei) respond to a hypertrophic stimulus could provide a critical step toward understanding compromised skeletal muscle plasticity with age. We used recombina...

Background/Aim: To investigate the relationship of the -799C/T (rs11225395) and -381A/G (rs1320632) matrix metalloproteinase 8 (MMP8) gene polymorphisms with periodontitis and the levels of active MMP-8 (aMMP-8) in an or...

Clinical PresentationPatients with germline TET2 loss of function exhibit a syndrome of immunodeficiency, autoimmune lymphoproliferation, developmental delay, and predisposition to lymphoma. An 8-week-old infant was admi...

Abstract The unambiguous identification of individual chromosomes is fundamental to studying genome organisation and evolution. Sheepgrass (Leymus chinensis (Trin.) Tzvel), a perennial tetraploid grass closely related to...

This report aimed to study the interference in molecular testing for Ehrlichia canis and Anaplasma platys in blood of 155 dogs from the coastal region of Rio de Janeiro. Five Anaplasmataceae positive samples but negative...

Abstract Histone modifications and chromatin‐binding proteins play crucial roles in regulating gene expression in eukaryotes, with significant implications for fungal pathogenicity and development. However, profiling t...

Abstract Background Radioresistance remains a major obstacle in oral squamous cell carcinoma (OSCC) therapy. This study aimed to elucidate the role of abnormal alternative splicing (AS) and key splicing factors in this p...

La tipificación de los grupos sanguíneos y polimorfismos bioquímicos a partir de muestras de sangre y suero sigue siendo el estándar internacional para la certificación de paternidad. En la actualidad, las mencionad...

"El advenimiento de la secuenciación masiva (NGS) ha hecho posible interrogar el genoma en búsqueda de variantes que afecten el desarrollo y el tratamiento del cáncer. El cáncer es una enfermedad que se origina en la...