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Abstract Background Recent studies highlight the critical role of gut microbiota in sepsis pathogenesis and its potential link to neurological disorders, particularly sepsis-associated encephalopathy (SAE). However, the ...

Abstract Neutrophil-driven inflammation is central to the pathogenesis of chronic obstructive pulmonary disease (COPD). Emerging evidence suggests that Ca²⁺ signaling is critical in regulating neutrophil activation, r...

Introduction and Aims: Evidence suggests a relationship between oral microbiota and cardiovascular diseases (CVDs). However, the roles of specific microbiota in the pathogenesis of CVDs remain underexplored. Methods: Two...

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease of unknown etiology. Several signaling pathways associated with oxidative stress, such as Nrf2, NOX and NF-κB, have been implicated in the pathogenesis ...

The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS2) affected the geriatric population. Among research models, Golden Syrian hamsters (GSH) are one of the most representative to study SARS2 pathogenesi...

Abstract The 24th International Pathogenic Neisseria Conference (IPNC) marked a shift toward a balanced forum addressing both meningococcal and gonococcal disease. This drove discussion on how multivalent meningococcal v...

Abstract Background Endocrinopathic laminitis develops in association with insulin dysregulation, but the role of insulin in the pathogenesis remains unclear. Hyperinsulinemia can cause hypoaminoacidemia, which is associ...

Abstract Objective Missed abortion occurs in ~ 15% of all clinical pregnancies. The pathogenesis is not clearly known. However, defective placentation resulting in maternal systemic inflammatory response is considered r...

Prurigo nodularis is a chronic skin disease, especially seen in middle-aged women adults. It is characterized by symmetric, pruritic hyperkeratotic nodules and papules on the extensor surfaces [1]. Prurigo nodularis pati...

Psoriasis is a chronic inflammatory skin disease associated with increased proliferation of the epidermis. Combination of genetic, immunological and environmental factors underlies the skin lesion. Until recently, psoria...

Recent studies have shown that the presence of an RNA modification, N6-methyladenosine (m6A), in viral RNAs during infection significantly impacts the outcome of viral replication and pathogenesis. In particular, various...

Insulin resistance and sympathetic activation are shown to play a role in the pathogenesis of essential hypertension. The role of sympathetic activation in essential hypertension has been documented by a variety of tec...

ABSTRACT Background and Aims The Charcot–Marie–Tooth disease (CMT) comprises genetically diverse motor and sensory neuropathies. This study aims to conduct a comprehensive investigation into the current academic and ...

Heart failure with preserved ejection fraction (HFpEF) is a complex cardiovascular disorder characterized by diastolic dysfunction, metabolic dysregulation and limited therapeutic options. Post-translational modification...

Apoptosis is a physiological mechanism of programmed cell death, in contrast to necrosis, without eliciting an inflammatory response. It plays the key role in the functioning of different tissues and organs. The balance ...

Abstract Background ADAM10 and ADAM17, members of the membrane-bound disintegrin metalloproteinase (ADAM) family, act as α-secretases in the non-amyloidogenic processing of the amyloid precursor protein. While alteratio...

Usually increased presence of Heat Shock Proteins (HSPs) is considered to mediate inflammation process in Oral Lichen Planus (OLP) lesions, but in contrast HSP-70 expression found to be stable or even decreased in those ...

ABSTRACT Fast-growing broilers are prone to pulmonary hypertension, which is the main cause of death in broilers with ascites syndrome (AS). The underlying mechanisms of AS and the role of metabolomics changes involved i...

Abstract Background Spexin (SPX) is a peptide hormone that regulates body weight, adipose tissue metabolism, and food intake. Hypothesis Serum SPX concentration correlates with body condition score (BCS) and markers of o...

Oxidative stress (OS), derived from an imbalance between reactive oxygen species (ROS) accumulation and impaired antioxidant defense, is a recognized cause of atherothrombosis, through a complex interaction between low-g...

ABSTRACT Background Chronic enteropathies (CE) are common in cats, and alterations of the intestinal microbiota might be involved in the pathogenesis. Hypothesis/Objectives To evaluate the efficacy of a single enema feca...

Skin tags are classified as benign lesions. They occur mainly on the skin of the neck, eyelids, armpits, and groin as pedicles and soft nodules. Their occurrence is associated with obesity, insulin resistance, atherogeni...

ABSTRACT Staphylococcus aureus is a common upper respiratory tract (URT) pathobiont with high carriage rates in the upper airway disease chronic rhinosinusitis (CRS). CRS is associated with increased prevalence and abund...

This consensus statement update reflects our current published knowledge and opinion about clinical signs, pathogenesis, epidemiology, treatment, complications, and control of strangles. This updated statement emphasizes...