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Background and Aim: Cerebral ischemia is a major neurological condition that contributes significantly to global morbidity and mortality. It occurs due to reduced blood supply to the brain, leading to neuronal injury and...

Neurodegenerative disorders represent a major and growing global health challenge, characterized by progressive neuronal loss, multifactorial pathophysiology, and limited disease-modifying pharmacological options. Increa...

BackgroundGranulomatous-lymphocytic interstitial lung disease (GLILD) is a major cause of morbidity and mortality in common variable immunodeficiency (CVID), yet its pathophysiology remains incompletely understood, and n...

Lucie Bartova,1 Mara Lisa Beuster,2 Bruno Bonetti,3 Giuseppe Maina,4,5 Pedro Morgado,6 Johan Nyberg7 1Department of Psychiatry and Psychotherapy, Clinical Division of General Psychiatry, and Comprehensive Center for Clin...

Carotid artery stenting (CAS) has emerged as an effective alternative to carotid endarterectomy for treating carotid artery stenosis, particularly in high-risk surgical patients. However, in-stent restenosis (ISR) remain...

Introduction and purpose. Plantar fascia is a structure ensuring proper stabilization of the foot. Its malfunction impacts the organism as a whole. Untreated pathology leads to further health consequences. Plantar fascii...

Brain-Derived Neurotrophic Factor (BDNF) is the most abundant neurotrophin in the central nervous system with essential roles in neurodevelopment and maintenance of healthy brain function. Accordingly, BDNF has been sugg...

Abstract IgG4-related disease (IgG4-RD) is a systemic inflammatory condition marked by tissue infiltration of IgG4-positive plasma cells, often resulting in fibrosis. While IgG4-RD commonly affects organs such as the pan...

Patients with end-stage-renal disease (ESRD) experience a high cardiovascular mortality and cardiovascular risk factors such as obesity, hyperlipidemia and hypertension are very common. Recent epidemiological research ha...

ObjectivePolycystic ovary syndrome (PCOS) is a complex endocrine disorder. In this study, we characterize serum bile acids (BAs) metabolic profiles in PCOS patients using targeted metabolomics and investigated their corr...

Gitelman syndrome (GS) is a rare hereditary kidney disorder characterized by electrolyte abnormalities. However, its systemic manifestations, such as growth retardation, suggest broader metabolic disturbances. To investi...

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic condition characterized by hepatic fat accumulation and systemic metabolic dysfunction. MASLD exhibits clear sex differenc...

Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disease characterized by heterogeneous symptom patterns. Previous work suggested that specific symptoms tend t...

ABSTRACT Background and Aim Post‐acute sequelae of SARS‐CoV‐2 infection (PASC), commonly referred to as long COVID, has emerged as a significant global health concern, marked by persistent symptoms and chronic infl...

Abstract Background Heart failure with preserved ejection fraction is the fastest-growing subtype of heart failure, especially among the elderly. Aim It is aimed to determine whether the addition of 10 mg of Dapaglifloz...

The purpose of research. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, characterized by metabolic, hormonal, reproductive, and psychological disturbances. Its pa...

Tianqing Zhang,1 Sijie Xiao,2 Yanfu Xia,3 Kun Chen,1 Honglan Liu,1 Ping Zhang,1 Li Luo1 1Department of Cardiology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of ...

ABSTRACT Background Intervertebral disc degeneration (IVDD), a prevalent spinal disorder, is closely associated with abnormal mechanical stress. The nucleus pulposus (NP), annulus fibrosus (AF), and cartilaginous endplat...

Abstract Juvenile idiopathic arthritis (JIA) is an umbrella term for a group of oligo- and poly-arthritic conditions that develop before 16 years of age. While the exact pathophysiology of JIA is still unknown, both gene...

Thrombotic thrombocytopenic purpura (TTP), an insidious and often devastating thrombotic microangiopathy, represents one of the few true hematologic emergencies. Since the identification of the von Willebrand factor (VWF...

Although our current knowledge of the pathophysiology of COVID-19 is still fragmentary, the information so far accrued on the tropism and life cycle of its etiological agent SARS-CoV-2, together with the emerging clinica...

Arterial Tortuosity Syndrome (ATS) is a rare autosomal recessive connective tissue disorder caused by mutations in the SLC2A10 gene encoding the glucose transporter GLUT10. GLUT10 deficiency leads to the accumulation of ...

Background: Trapezius myalgia (TM) is a prevalent condition characterized by upper back and neck pain, commonly affecting those engaged in prolonged desk work, repetitive overhead activity, or manual labour. The conditio...

As síndromes hipertensivas na gestação merecem especial destaque no cenário da saúde pública mundial. Atualmente, respondem como terceira causa de mortalidade materna no mundo e primeira no Brasil. Do ponto de vist...