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IntroductionActivated Phosphoinositide 3-Kinase Delta Syndrome (APDS) is a rare disease characterized by progressive symptoms that begin early in life, including lymphoproliferation, recurrent and persistent infections, ...

BackgroundThis study evaluated two models of routine HIV testing of hospitalized children in a high HIV-prevalence resource-constrained African setting. Both models incorporated "task shifting," or the allocation of task...

ObjectiveThis study aimed to compare the safety and feasibility of transumbilical laparoscopic-assisted appendectomy (TULAA) vs. three-port laparoscopic appendectomy (TPLA) for the treatment of acute appendicitis in chil...

Resumen La enfermedad de Behçet es una vasculitis multisistémica cuya etiopatogenia es aún desconocida. Las complicaciones arteriales que tienen una relación directa con la enfermedad en las formas pediátricas son m...

Hydrochlorothiazide (HCTZ) is a thiazide diuretic used in pediatric patients despite the lack of a liquid form commercially available. Pediatric suspensions containing 0.6% of CMC-Na (F1) or 0.6% of HPMC (F2) were develo...

Problemas Relacionados aos Medicamentos (PRM's) são quaisquer eventos indesejáveis apresentados pelo paciente, que envolvam ou suspeita-se de estarem relacionados com a farmacoterapia. Este trabalho objetivou analisa...

As penicilinas constituem os fármacos de escolha no tratamento das infecções. Na pediatria, sua utilização requer atenção especial, sobretudo na adequação posológica. Objetivando avaliar a terapia farmacológ...

Severe gingival inflammation, which is uncommon in pediatric patients, often indicates underlying systemic conditions. Leukemia, autoimmune diseases, and allergic symptoms can cause gingivitis owing to systemic inflammat...

Abstract Background Collagenous fibroma (CF), also known as desmoplastic fibroblastoma, is a rare benign fibroblastic/myofibroblastic tumor characterized by FOSL1/FOS rearrangements. CF typically presents as a solitary, ...

Abstract Background In pediatric chronic extrahepatic portal vein obstruction (EHPVO), contrast-enhanced computed tomography (CECT) may provide suboptimal visualization of intrahepatic portal vein (PV) branches and may t...

Abstract Introduction Bordetella pertussis infections have resurged globally, posing notable public health challenges, particularly in pediatric populations. Poland remains the only EU country that continues to use the w...

Abstract Background Port-A-Cath needle insertion in pediatric chemotherapy is often painful and stressing. Distraction is a non-pharmacological method of pain management in invasive procedures in children. The purpose of...

Abstract Background Treating severe forms of the acute respiratory distress syndrome and cardiac failure, extracorporeal membrane oxygenation (ECMO) has become an established therapeutic option. Neonatal or pediatric pat...

Tuberculosis (TB) is an infectious disease and one of the major causes of mortality worldwide, especially in children under the age of 15 years. Abdominal TB includes TB of bowel, peritoneum, lymph nodes, or other soli...

ObjectivesAlthough therapeutic drug monitoring (TDM) for isavuconazole (ISA) is not routinely recommended, its utility in specific populations remains debated. This study aimed to elucidate the need for ISA TDM and to id...

Background: Therapeutic drug monitoring facilitates the individualiza­tion of amikacin dosing for patients based on pharmacodynamics and pharmacokinetics. Its efficacy is measured by peak serum concentration (Cpeak) / m...

Abstract Ventricular shunt catheters are the standard of care for managing hydrocephalus, yet 40% of implanted catheters fail within two years of implantation, mainly due to proximal catheter obstruction. Prior literatur...

Abstract. With levels of medicine and pharmacology individualization constantly increasing, the scientific community is becoming seriously concerned about the safety of existing and developing drugs for the pediatric pop...

Introduction: Complete traumatic disruption of the anorectal sphincter in children is rare and surgically challenging. High-grade penetrating injuries with delayed presentation and heavy fecal contamination carry signifi...

Background: Febrile illness in pediatric populations often poses a diagnostic challenge due to overlapping clinical features across various etiologies. While respiratory infections are common, urinary tract infections (U...

Background/objectivesNeurofibromatosis type 1 (NF1) is a common genetic disorder often accompanied by cognitive, behavioral, and neurodevelopmental disorders. While tumor-related manifestations are well-documented, less ...

Introduction: Reconstruction of complex abdominal wall defects in pediatric patients remains technically challenging. Botulinum toxin type A (BTA) has been used as a preoperative adjunct in adults, with limited experienc...

Introduction: Non-islet cell tumor hypoglycemia (NICTH) in pediatric patients is an uncommon phenomenon often presenting with neuroglycopenic symptoms with further workup identifying a mass. Renal solitary fibrous tumors...

Xiaohua Zheng,1,2 Chaoqin Lin,2 Yunyan Zheng,3 Yu Wang,2 Ying Xu2 1Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian University of Traditional...