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Abstract Background Covalent protein modification by drugs or their reactive metabolites has emerged as an important mechanism underlying pharmacological activity. However, its contribution to the therapeutic effects of ...

Abstract Background Neuroinflammation following intracerebral hemorrhage (ICH) is a critical contributor to secondary brain injury. Lactylation modification, a novel epigenetic regulatory mechanism, may participate in pa...

Abstract Background Poly (ADP-ribose) polymerase inhibitors (PARPis) are the standard of care for primary ovarian cancer (OC), yet adverse events (AEs) frequently necessitate dose modifications. The prognostic impact of ...

Abstract Background Diffuse large B-cell lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin lymphoma. Fatty acid synthase (FASN) is a key lipogenic enzyme implicated in tumor progression, but its regulation in DLBC...

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) stands as the most widespread chronic liver disorder globally. Histone β-hydroxybutyrylation (Kbhb)—a novel post-translational modif...

Abstract Background Witches’ broom is an important disease of the Paulownia fortunei. Understanding the pathogenesis of witches’ broom is a prerequisite for its prevention and control. Phytoplasma is the pathogen of ...

Abstract Background Cardiac fibrosis is a pivotal pathological process driving adverse cardiac remodeling and a defining feature of end-stage heart disease. Nicotine, a principal constituent of tobacco products, is now r...

Abstract Fungal histone methylation modification (HMM) includes methylation and demethylation at the histone lysine/arginine residues, which are catalyzed by the methyltransferases (HMTs) and demethylases (HDMs) of histo...

Abstract Histone post-translational modifications epigenetically regulate gene expression by modulating nucleosome structure and DNA accessibility. This review outlines how unique patterns of modifications on canonical ...

Abstract Background A rapidly rising prevalence of hypertension (HTN) is observed in low-and-middle-income countries but few studies explore factors such as attitudes and beliefs, experiences and social and cultural cond...

Abstract Objective Tuberculosis (TB) remains a global health threat with an incompletely understood pathogenesis. The RNA epigenetic modification N6-methyladenosine (m6A) is a key regulator of immune responses in various...

Abstract Objectives The objectives of this study were: (1) to compare the incidence of effective orifice area (EOA) after either the trans-catheter and surgical aortic valve replacement (SAVR); and (2) to assess the impa...

Abstract Background Prostate cancer (PCa) is a common malignant tumor in men, with a high incidence rate, posing a serious threat to human health and quality of life. Neddylation is a major post-translation modification,...